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Roughly 50 percent of all startups fail within their first five years. Many others struggle to stay afloat, let alone grow. But these founders have not merely survived, they’ve excelled—becoming the heroes of the most terrifying, exhausting, and exhilarating journey of their lives

​AS A 21-YEAR-OLD COP IN rural Missouri, Caleb Arthur rushed to the site of a meth lab explosion and—fearing there were children inside—entered the building. The lungful of anhydrous ammonia he inhaled consigned him to bed for four months. When his pregnant wife urged him to seek alternative employment, Arthur launched a solar-equipment-installation business, even though he was still racked by pain, with devastating headaches and unrelenting thirst. Most of his customers were in St. Louis, so for two years he logged 5,000

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