Nautilus

How Odd Behavior in Some Young Horses May Reveal a Cause of Autism

By gently squeezing maladjusted foals, veterinary researcher John Madigan recreates the experience of traveling through the birth canal, lowering the levels of certain neurosteroids and “waking up” the young horses.Joe Proudman / UC Davis

As a toxicologist at the University of California, Davis, Isaac Pessah focuses on how different molecules regulate human brain function and development. Yet when he found himself at the university’s equine research center, watching a troubled newborn foal, he was struck by its eerily familiar clinical symptoms.

Horses are prey animals, and like most animals whose chief form of defense is flight, they are up on their feet almost immediately after birth. At first they stagger around in the straw in their stalls, pitching their

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