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ti tiu lun:
NI DUNG
I. Gii thiu chung v Vibrio cholerae
1.1 Lch s ra i: o V. cholerae c nh gii phu hc ngi Filippo Pacini xc nh gy ra bnh t vo nm 1854, nhng khng c cng nhn rng ri.
o Sau 30 nm, vi trng t c Robert Koch xc nh l tc nhn gy bnh t vo nm 1883 trong mt v dch Ai Cp. Sau vo nm 1905, Gotschlich phn lp c 6 dng. Vibrio cholerae c bit ti Eltor nhng mi n nm 1961, Vibrio cholerae loi sinh hc Eltor mi c nhn nhn l Robert Koch (1843-1910) c kh nng gy dch ln.
o V. cholerae v cc loi khc thuc chi Vibrio thuc v lp gamma ca ngnh Proteobacteria. C hai chng V. cholerae chnh, chng c in v chng El Tor, v mt s nhm huyt thanh khc.
Da
vo c tnh vi khun V. cholerae c th chia thnh 2 nhm chnh theo huyt thanh : l O1 v O139. Nhm O1 c hai tp sinh hc : El Tor v c in.
Mi tp sinh hc El Tor hay c in c th chia thnh 3 nhm nh theo huyt thanh: Ogawa, Inaba, v Hikojima. Mi nhm cn c th chia thnh nhm nh hn da vo khng nguyn A, B, hay C.
Loi(species):
V.cholerae
Cholerae ln men khng sinh kh, c kh nng lm dch ha gelatin C kh nng kh nitrat thnh nitrit v phn gii trytophan thnh indol Vibrio cholerae pht trin c vng c nng mui cao 3% C kh nng ln men ng glucose, sucrose,mannose
Viibrio cholerae c dng hnh que mng, hi cong ging du phy (cn c gi l phy khun), kch thc 0,3-0,6 1,5 m, c chng a mn v chng khng a mn.2
S cu to t bo vi khun V.Cholerae:
Tin mao
Khun mao
Cu to
Chim t 20-30% khi lng kh ca t bo. Thnh phn cu to: -Peptidoglycan: chim t 5-20% khi lng cht kh ca thnh t bo. -Polysaccharide -Lypopolysaccharid: 2 thnh phn chnh o Lipid o Protein -Cu to gm 2 lp: -Mng ngoi -Peptidoglycan
H tr qu trnh phn ct t bo
Cu to:
Mng sinh cht c cu to bi 2 lp: Phospholipid chim 30-40% khi lng ca mng. u phosphat tch in, phn cc, a nc ui hydrocarbon khng tch in, khng phn cc, k nc. Protein (nm trong, ngoi hay xen gia mng), chim 60-70% khi lng ca mng
Cu tao:
L phn vt cht dng keo nm bn trong mng sinh cht, cha ti 80% l nc. Trong t bo cht c protein, acid nucleic, hydrat carbon, lipid, cc ion v c v nhiu nhiu cht khc c khi lng phn t thp nn mng sinh cht dc chia thnh 2 phn: Phn 1: Cytosol lng Phn 2: Cc vt th l lng trong cytosol.
hai tiu phn ny kt hp vi nhau to thnh ribosom 70S. Chc nng: Ribosome l ni tng hp nn Protein
Th nhn ca Vibrio cholerae dng nhn nguyn thu, cha c mng nhn nn khng c hnh dng c nh, v v vy cn c gi l vng nhn. Khi nhum mu t bo bng thuc nhum Feulgen c th thy th nhn hin mu tm. l 1 nhim sc th (NST, chromosome) duy nht dng vng cha 1 si ADN xon kp. Chc nng: Ni lu tr thng tin di truyn v truyn t thng tin di truyn.
Vibrio cholerae c mt lp mng nhy bao bc quanh t bo (khi nhum mu vi khun ta thy c mt lp mng trng trong sut bao quanh).Thnh phn c bn ca mng l nc (n 98%), 2% cht kh cn li l polysaccharide.
Hnh nh bao nhy ca Vibrio cholerae di knh hin vi sau khi nhum mu.
Tin mao c gc (basal body), gm 1 tr nh c gn vi 4 a trn c dng vng nhn, k hiu l cc vng L,P,S v M. Vng L nm ngoi cng, tng ng vi lp liposaccarid ca mng ngoi ; vng P tng ng vi lp peptidoglycan, vng S tng ng vi lp khng gian chu cht ; vng M nm trong cng.
Khun mao (hay Tim mao, Nhung mao , Fimbriae) l nhng si lng rt mnh, rt ngn mc quanh b mt Khun mao t bo vi khun. Chng c ng knh khong 7-9nm, rng rut (ng knh trong l 2-2,5nm), s lng khong 250-300 si/ vi khun. Kt cu ca khun mao gin n hn nhiu so vi tin mao. Chc nng: Gip Vibrio cholerae bm vo rut non (gi th)
III.1 Kh nng gy bnh ngi b)Khi qut v lch s bnh i dch ton cu:
V.cholerae
O1
O139
O1
C in Eltor
O139
Eltor
Vit Nam hin cha ghi nhn c V. cholerae O139
Vibrio cholerae xm nhp vo c th qua ng phn ming Bnh thay i theo ma. Vit Nam bnh thng vo ma nng thng (2, 3, 4) 75% nhim vi khun t khng triu chng nhng vn thi vi khun ra mi trng 7-14 gy Nhng ngi c triu chng th hin nh v va 80%
Vi khun sau khi nhim qua ng ming phn ln b tiu dit bi acid trong dch v, cn li s tip tc n rut non. Ti y, Vi khun s tit c t Cholerae Toxin (CTx) lm xut tit nhiu cht in gii (K+, Na+, Cl-, HCO3-) v nc trong lng rut.
Mt K+
Mt nc v nhiu cht in gii
Gy vp b
IV.1 Lm sng
a) bnh b) Khi pht c) Ton pht Bnh nhn tiu chy t, xi x, r r lin tc, c th n 30 ml/kg trng lng. Nn: bnh nhn nn d dng, lc u ra thc n, sau ra nc, thng xut hin sau tiu chy. Thng khng st, t au bng. Mt l cht rt
IV.2 Cn lm sng
Soi phn: gip chn on nhanh. Cy phn: dng tnh vi Vibrio cholerae 01 hoc 0139 +Phi ly phn sm, truc khi iu tr khng sinh. +Cy phn vo mi trung chuyn bit. Phy khun t mc rt nhanh v c th xc nh sau 24 gi.
IV.2 Cn lm sng
Tnh trng c c mu: t trng nc tiu tng. Tnh trng ri lon in gii: gim kali, gim bicarbonat, pH
thp.
Suy thn: ur v creatinin mu tng
VI. Kt lun
Vibrio cholerae l nguyn nhn chnh gy nn bnh t. N ly lan nhanh chng v tr thnh i dch ton cu. Qua , chng ta hiu hn v vi khun Vibrio cholerae v bnh t => bit c triu chng lm sng, nguyn nhn v cch iu tr bnh, cng nh cc phng php kim nghim vi sinh trong CNTP
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.
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