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Tuyn tp Bo co Hi ngh Sinh vin Nghin cu Khoa hc ln th 6

i hc Nng - 2008

NGHIN CU TC NG CA NH SNG C NNG LNG LN V NHIT CAO LN MT S THUC TN DC


RESEARCHING THE EFFECTS OF LIGHT WITH HIGH ENERGY AND TEMPERATURE ON SOME DRUGS SVTH: TRN TH HI T1 GVHD: Th.s L VN THANH SN2
1. Lp 04VL, Trng i hc S phm Nng 2. Khoa Vt L, Trng i hc S phm - i hc Nng
TM TT Trong bi bo ny, tc gi a ra mt s kt qu nghin cu v nh hng ca nh sng c nng lng ln v nhit cao ln mt s thuc tn dc. T nhng kt qu thc nghim thu c tc gi rt ra nhng kt lun km theo. ABSTRACT In the paper, the author presents some results on the effects of light with high energy and temperature on some drugs. By the obtained results, the author draws some attached conclusions.

1. M U Thuc l c s vt cht iu tr v d phng cc bnh tt. c tnh ca thuc c lin quan ti l ho tnh v cu trc ho hc ca thuc, ch cn mt vi thay i nh trong cu trc ho hc ca thuc c th nh hng ln n hot tnh ca thuc v lm thay i tc dng ca thuc trong c th. V vy, vic s dng thuc v bo qun thuc, c bit l vic bo qun thuc l rt quan trng v lun c ch trng. Cu hi t ra l lm sao c th bo qun thuc lu di m khng lm thay i cht lng cng nh tc dng ca thuc? Cng tc kim nghim cht lng ca thuc l rt quan trng. Hin ny, vi s tin b ca KHKT c rt nhiu phng php kim nghim khc nhau. Mt trong s c s dng rng ri nht l phng php quang ph hp th UV-Vis. i tng kho st y rt a dng, c mt s cng trnh tin hnh kho st c s nh hng ca cc yu t nh: nhit , m, nh sng n vic bo qun thuc. Vi nh sng th ch gii hn nh sng kh kin. Vy liu nh sng t ngoi c nh hng g n cu to v thnh phn ca thuc khng? Khi m nh sng mt tri chiu ti tri t c thm thnh phn ny do l thng tng zn. Vi iu kin hin c ca Phng th nghim chuyn Khoa Vt L Trng i hc S phm, chng ti tin hnh kho st nh hng ca nhit v nh sng t ngoi n ph hp th ca mt s thuc tn dc, qua rt ra c mt s cc kt lun cn thit cho vic bo qun mt s tn dc. chnh l l do chng ti chn ti: Nghin cu tc ng ca nh sng c nng lng ln v nhit cao ln mt s thuc tn dc 2. PHNG PHP V VT LIU Phng php quang ph hp th UV-Vis l mt trong nhng phng php phn tch da trn s hp th bc x in t c bc sng nm trong vng t ngoi gn (200 400nm) v trong vng kh kin (400 700nm). y cng l mt phng php hin i c p dng rng ri trong nhiu lnh vc. Phng php ny c s tr gip ca my quang ph hai chm tia SPECTROSCAN - 80DV, kt qu ph hp th ca cc cht kho st c hin th ngay trn mn hnh vi tnh.

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Tuyn tp Bo co Hi ngh Sinh vin Nghin cu Khoa hc ln th 6

i hc Nng - 2008

Vic x l ph rt thun tin vi phn mm UVWin tin tin cho php thc hin nhiu chc nng cng mt lc. Ph hp th thng c biu din di dng mt ng cong cho thy s ph thuc hp th ca mt cht bt k trng thi dung dch vo bc sng ca nh sng chiu ti. Mi ng cong nh th c c trng bi bc sng max m ti s hp th l ln nht. phn tch s nh hng ca cc tc nhn bn ngoi ti cht m ta kho st thng qua ph hp th ca chng, ta tin hnh o ph hp th trc v sau khi x l, sau so snh s thay i ca cc nh ph v rt ra cc kt lun cn thit. Vt liu kho st trong ti l Calcium corbire. y l loi thuc b sung calci, thnh phn chnh l calcium glucoheptonat. Bn trn th trng di dng dung dch ng trong ng 10ml, 5ml. Mi mililit cha 110mg calcium glucoheptonat hoc 9mg ion Ca2+. Chng c pha trong dung mi nc ct thnh cc dung dch c nng thch hp ( tho mn nh lut Lambert Beer). Dung dch c pha vo cc Cuvet ra sch, dung dch cha x l c o ph v lu gi lm ph chun. Sau chia lm 2 phn, phn 1 em chiu t ngoi trong 15ph, 30ph, 45ph, 60ph bi n Xenon 75W vi khong cch 10cm. Phn 2 c sy nhit 35oC, 40oC, 50oC trong 30ph, 45ph, 60ph bi l sy. 3. KT QU V NHN XT Sau khi tin hnh x l mu, em o ph v thu c cc kt qu nh sau: 3.1. Ph hp th ca dung dch Calcium corbire cha x l v sau khi sy nhit 35oC, 40oC, 50oC: Nng dung dch l 0,1mg/ml.

Hnh 1: Ph hp th ca dung dch Calcium Corbire khi sy nhit 350C


Ph cha x l nhit Ph x l nhit trong thi gian 30 pht Ph x l nhit trong thi gian 45 pht Ph x l nhit trong thi gian 60 pht

Hnh 2: Ph hp th ca dung dch khi sy nhit 400C


Ph Ph Ph Ph cha x l nhit x l nhit trong thi gian 30 pht x l nhit trong thi gian 45 pht x l nhit trong thi gian 60 pht

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Tuyn tp Bo co Hi ngh Sinh vin Nghin cu Khoa hc ln th 6

i hc Nng - 2008

Hnh 3: Ph hp th ca dung dch sy nhit 500C


Ph cha x l nhit Ph x l nhit trong thi gian 45 pht Ph x l nhit trong thi gian 60 pht

*Nhn xt: Dung dch Calcium Corbire khi c sy cc nhit khc nhau trong nhng khong thi gian khc nhau, ta thy: + Khi chu tc ng bi nhit , cc cc i dch chuyn v pha sng di. Trong khong bc sng nh hn 240nm th nh ph b mt. Nhit sy cng cao, thi gian sy cng ln th t l cng hp th thay i r rt, dng ph cng thay i theo. nhit 500C ph hp th thay i hon ton, nh ph mt. V tr tng i ca hai nh ph thay i r rt so vi mu cha x l. 3.2. Ph hp th ca dung dch Calcium corbire khi cha x l v sau khi chiu nh sng t ngoi: Nng dung dch Calcium corbire l 0,1mg/ml.

Hnh 4: Ph hp th ca dung dch Calcium Corbire khi chiu t ngoi


Ph cha x l Ph x l chiu nh sng t ngoi trong thi gian 15 pht Ph x l chiu nh sng t ngoi trong thi gian 30 pht Ph x l chiu nh sng t ngoi trong thi gian 45 pht Ph x l chiu nh sng t ngoi trong thi gian 60 pht

*Nhn xt: Khi b chiu x bng t ngoi trong thi gian 15ph dng ph thay i rt t. Tng thi gian chiu n 45ph th ph hp thay i, t l cng hp th gia hai nh thay i r rt. V khi chiu n thi gian 60ph th ph hp th thay i hon ton, nh ph mt. Sau mt thi gian tin hnh thc nghim chng ti rt ra c kt lun sau: Khi chu tc ng ca nh sng t ngoi v nhit , ph hp th ca dung dch Calcium Corbire thay i. Chng t nhit v nh sng t ngoi u nh hng n thuc Calcium Corbire, c bit l nhit . Mc chu tc ng loi yu. So snh vi kt qu o ph hp ca dung dch Vitamin nhm B cng bng phng php ny v cng kho st nh hng ca nhit v nh sng t ngoi. Kt qu nh sau:

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Tuyn tp Bo co Hi ngh Sinh vin Nghin cu Khoa hc ln th 6

i hc Nng - 2008

Hnh 5: Ph hp th ca dung dch Vitamin B1 0,05mg/ml

Hnh 6: Ph hp th ca dung dch Vitamin B5 0,03125mg/ml

Hnh 7: Ph hp th ca dung dch Vitamin B6 0,025mg/ml


Ph cha x l nhit Ph x l nhit trong 5h 400C Ph x l nhit trong 5h 500C Ph x l nhit trong 5h 700C Ph x l nhit trong 5h 800C Ph x l chiu t ngoi

*Nhn xt: Nhit v nh sng t ngoi c nh hng n Vitamin. Vi Vitamin B1, B5 tng i n nh, ph c phn thay i c phn khng, mc chu tc dng tng i tt. Cn vi Vitamin B6 ph c s thay i r rt c bit vi vic chiu tia t ngoi. 4. KT LUN Vi nhng kt qu thc nghim thu c, so snh kt qu kho st i vi Vitamin nhm B ca cc tc gi khc, chng ti rt ra mt s kt lun nh sau: Tc ng ca nhit cao: Khi kho st nhit cao hn nhit phng, ph hp th ca dung dch Calcium Corbire thay i chng t c tc ng rt mnh n Calcium Corbire. Mc chu tc dng loi yu. Cn Vitamin nhm B n nhit 80 0C mi c s thay i, mc chu tc dng ca Vitamin tng i n nh.

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Tuyn tp Bo co Hi ngh Sinh vin Nghin cu Khoa hc ln th 6

i hc Nng - 2008

Tc ng ca nh sng c nng lng ln: C s thay i ca ph hp th r rt khi chiu nh sng t ngoi. Cng ging nh Vitamin nhm B. Thy thuc Calcium Corbire v Vitamin nhm B u chu tc ng ca nh sng c nng lng ln v nhit cao. Tu thuc vo tng loi m c s tc ng khc nhau. i vi dung dch Calcium Corbire chu tc ng mnh ca nhit hn nh sng t ngoi, cn Vitamin nhm B th chu tc ng mnh ca nh sng t ngoi hn nhit , mc chu tc ng ca Vitamin tng i n nh. Vi cc kt lun nh trn cho php xut mt s kin ngh: Vic bo qun thuc tn dc, c th y l Calcium Corbire v Vitamin nhm B cn quan tm n cc yu t mi trng xung quanh nh: nhit v nh sng c nng lng ln. i vi thuc Calcium Corbire chu tc ng mnh ca nhit , cn Vitamin nhm B chu tc ng ca nh sng c nng lng ln. TI LIU THAM KHO [1] L Tn Ngha (1997), Phn tch, nh gi tc ng ca mi trng bo qun n cht lng ca mt s loi thuc tn dc bng phng php hp th phn t, Lun vn thc s, Trng i hc khoa hc - i hc Hu. [2] Trn L Ngc Trm (2007), Tm hiu my quang ph UV Vis, kho st nh hng ca nhit n ph hp th ca mt s Vitamin thng thng, Lun vn tt nghip, Trng i hc s phm Nng. [3] L Ho (1975), Cu trc ph phn t, Nxb i hc v Trung hc Chuyn nghip, H Ni. [4] DS. Phm Thip DS. V Ngc Thu (2000), Thuc bit dc v cch s dng, Nxb Y hc, H Ni. [5] http://www.en.wikipedia.org/wiki/calcium

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