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NHM 1 TIU NHM 1

BO CO THC TP BO CH
THUC CM PARACETAMOL 120 MG
1. Cng thc:
T dc gy treo l Croscarmelose 1 3%
Cng thc cho 100 gi thuc cm (300 g cm)
Cng thc 1: Croscarmelose 1%

Cng thc 2: Croscarmelose 3%

Paracetamol

12 g

Paracetamol

12 g

Aspartame

4,5 g

Aspartame

4,5 g

Natri benzoate

0,15 g

PVP

3,2 g

Natri benzoate

0,15 g

PVP

5g

Croscarmelose natri

3g

Croscarmelose natri

9g

T dc mu

T dc mu

T dc mi

T dc mi

Saccarose

300g

Saccarose

2. Tin hnh:

Xt cm qua ry s 1

Sy khong 30 pht

o m: CT1: 1,98%
CT2: 2,44%

Sa cm qua ry s 0,5

Nhn xt: c 2 cng thc u d xt, kh nhanh khi sy, d sa ht


Ht cm u khng b vn nt
3. Kim tra cht lng:

300g

phn tn: thm 30 ml nc ct vo 3 g cm, khuy u.


CT1: phn tn sau 4s
CT2: phn tn ngay

sa lng: sau khi cm phn tn u, yn, o th tch sa lng ca cm


Vi kt qu nh sau
Pht

Th tch phn
dung dch trong
(ml)

ml

15

30

60

90

120

CT1

10

CT2

13

15

16
14
12
10

CT1

CT2

6
4
2
0
0

15

30

4. Cc tiu ch chn cng thc:

phn tn

sa lng

nht

Mi v

60

90

120

phut

K thut bo ch

Gi thnh

5. S quy trnh iu ch:

VIN NN STRYCHNIN
Cng thc cm
Bt Strychnin sulfat 1%

50g

Acid tartric

1.9g

Tinh bt

51g

Lactose
34g
PVP
5g
Khi lng cm ly thuyt 141.9 g
Khi lng cm thc t 123g
m cm 2.9 %
Goc chay : 29o
Cng thc bt em i dp vin
Cm strychnin
123 g
Thiamine HCl
8.67g
Talc
3.47g
Tinh bt
3.2 g
Kt qua kim nghim vin nen strychnin
ng u khi lng
0,1546
0,1642
0,1618
0,1615
0,1651
0,1637
0,1635
0,1639
0,1611
0,1635
0,1595
0,1625
0,1561

0,1627
0,1636
0,1637
0,1574
Mtb= 0,1618 , Khoang dao ng 0.1618 0.0121 ( 7.5%) at
mai mon : 1.2%
cng 94.5 N
ra : 6 phut
VIN NANG PARACETAMOL

Cng thc 1 cho 600 vin nang:


Paracetamol
PVP 10% (1%)
Croscarmelose (2%)
Talc (2%)

214g
2.5g
4.4g
4.4g

Cng thc 2 cho 600 vin nang:


Paracetamol
Gm Arabic (1%)
Lactose (2%)
Talc (2%)

214g
2.2g
4.4g
4.4g

Khi lng mt vin: 342mg


- iu ch cm toan phn:
Giai oan
Lam m bt
Sy hat ( m)
Chon nang: Vbk
Co talc
Khng talc

Cng thc 1
25 ml PVP 10%
1.34%
19.5g/32.5ml
V = 0.57 ml
20g/36.5ml
V = 0.61 ml

Cng thc 2
2.2g gm Arabic
1.33%
19 g/ 30ml
V = 0.54ml
20g/38ml
V = 0.64ml

- Ry cm toan phn:

Ry
> A3
A4 A3

A5 A4

Cng thc 1 (m = 185.5g)


Khi
lng
Co talc
Khng talc
cm
4.04g
10.75ml/4. 12ml/4.65
46.52g
66g
g
V=0.79ml
V=0.88ml
16.5ml/9.1 18.5ml/9.4
94.16g
5g
2g
V=0.62ml
V=0.67ml

Cng thc 2 (m = 182.2 g)


Kl cm

Co talc

Khng talc

10ml/5.42
g
V=0.63ml
12.5ml/7.2
7g
V=0.59ml

12.5ml/5.4
g
V=0.79ml
14.5ml/7.6
2g
V=0.65ml

4.63
54.01

76.2

< A5

40.54g

7ml/3.9g
V=0.61ml

7ml/4.05g
V=0.59ml

47.14

6.5ml/4.56
g
V=0.49ml

6ml/4.71g
V=
0.44ml

100
90
80
70
60
50
40
30
20
10
0
> A3

A4 A3

A5 A4

< A5

A5 A4

< A5

Cng thc 1
%

90
80
70
60
50
40
30
20
10
0
> A3

A4 A3

Cng thc 2
- Chon cm cng thc 2 co bt talc ong nang, khi lng cm con lai ong
nang la 164.28g
* 1 vin 342mg => 300 vin 102.6g
- Talc 2% : m1 = 2.05g
- Khi lng cm: m2 = 100.55g
Goc chay hat trc khi ong nang :
- em ong nang, thu 300 vin nang, co 4 vin bi hong.
Kim nghim:
o ng u khi lng: 20 vin nang (g)

0.3189
0.3232
0.3185
0.3275
0.3298
0.3122
0.3216
0.3228
0.3291
0.3287
0.3243
0.3245
0.3276
0.3297
0.3180
0.3265
0.3257
0.3282
0.3232
0.3242
mTB = 0.3083, gii han cho phep 7.5% ( 0.0231g)
=> 20 vin u at gii han cho phep
o ra: 5 vin la 6.2 phut => at yu cu trong vong 30 phut vi dung
mi nc

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