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2010



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(1 7) ,

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(7 10) e-health,
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(10 13)
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15 -,
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Fundamentals of Tele-medicine and its applications to modern medicine

:
1. .8
- 10
- ....10
- ...11
2. 13
- ...13
- ..15
3. .16
4. .24
4.1. ..24
4.2. .27
- 28
- ..29
- Video29
4.3. ...32
- (Twisted pair).32
- 33
- ...34
5. ..36
5.1. .36
5.2. ...37
5.3. .37
5.4....38
5.5.....39
5.6.T40
5.7...41
- ....42
- .43
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5.8.43
- ...44
5.9....44
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5.10....46
5.11...49
5.12....49
6. ..51
-.52
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- & 53
- 54
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4

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- video.56
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7. HOME CARE -HEALTH...60
-T home care .60
- e- health.61
- ' e-health .63
-, ..64
8. .66
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- 68
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9.. .72
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3. : (MOMEDA).....85
4.: '
86
- 87
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-91

11.
92
- ..92
- ..94
1. CENT/TC 25194
2. ACR94
3. HL7-Health Level Seven....94
4. IEEE94
5. American Telemedicine Association..95
- ..95
- .96
-CASESTUDY - ' 96
12. .98
1...98
- ....98
- .101
- ...104
- ..105
- / 105
2. ....106
-107
-111
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-...113
13. 114
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14. 124
15...128
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-131

1.

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Radio News, -
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1950,
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(Interactive) 1960

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1960, , NASA
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1970
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1990,
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Internet,

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1996,
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Primetime 3".

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(end to end).
(data) (bearer channel)
(bandwidth) 64 Kbit/s. D
16Kbit/s 64 Kbit/s.
ISDN:
ISDN 64Kbit/s, (
, data, fax, ) D 16Kbit/s,
144Kbit/s. 30 1
D 64Kbit/s, 1984 Kbit/s.
ISDN
:

16


:
Internet
fax .

: Internet ,
(PTSN).


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ISDN ISDN
group 4,
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ISDN
(..
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386 kbps.

ADSL(Asymmetrical Digital Subscriber Line).

(.. )

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(modulation).
ADSL modem
(splitter). To modem H/Y LAN
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splitters () ,
.

17

: ADSL

ADSL :

(LAN)


, ATM (Asynchronous Transfer
Mode). ATM cells, TCP/IP
.
(multiplexing)
. cells : 53 bytes 48
(information) 5
(header). cells
virtual
channels.
(switches).
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(real time video),
teleconsulation
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18


. GSM (Global System for Mobile Communications)
.

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GSM . GPRS
(General Packet Radio System)
14,4 Kbit/s .
(S)

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, (3G).
EDGE UMTS.
GSM
384 Kbit/s.
UMTS. UMTS
(CDMA) ' GSM 384
Kbit/s 2 Mbit/s .
UMTS ,
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VSAT(Very Small Aperture Terminal).
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hub ( ) .
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ku-band(uplink 14/ downlink 12 GHz) Cband (uplink 6 / downlink 4 GHz). :
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19


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(Browsers) .
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arrays)

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(Servers)

(middleware)
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kilobytes megabytes
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spreadsheet
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PC .
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PC s WAV format
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pixel (
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(scanner) ,
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pixel pixels
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1200 (dots) pixels
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35 mm 1000x1200 pixels
pixels. pixel
bits grey-scale
8 bits (255 ) grey-scale 24 bits (16,77 )
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large matrix 2000 pixel x 2000 pixel x
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525
frame rate 25 .
PAL (Phase Alternating Line)
, 625
frame rate 25 .


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Intermediate Format) NTSC
PAL 288 30
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4.2.

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software
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Hardware,
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Huffman
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28



Huffman.
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graphical digitized .
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graphical ,
digitized .
digitized
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JPEG (Joint Photographic Expert Group)


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baseline mode lossy sequential mode.

: 1)image 2) block
preparation 3) Forward DCT 4) Quantization 5) Entropy encoding 6)
Framebuilding.

Jpeg blocks.
blocks
(RGB).
block DCT. quantization

.

frames .
.

Video
video
.
videoconferencing, video .

video ,
.

29

H video
.
(frames)
. video
. video
standards.

video

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frames. video

. moving JPEG MJPEG.
10:1
20:1.
3 sec
180 frames.

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frame
frames
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frames frames.
frames
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motion estimation. frames

frame
frame.


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. motion compensation.

MPEG
Motion Pictures Experts Group
() video
. video
,
,

30

.
MPEG :


MPEG 1:
352x288 pixels. VHS
.
1.5
Mbps, .

MPEG 2:
studio . format 4
:
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MPEG 1 VHS.
CD 4 Mbps.
-Main: 720x576 pixels. studio
CD.
15Mbps 20 Mbps.
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(HDTV)
60 80 Mbps.
-High: 1920x1152 pixels.
(wide screen High
Definition TV). 80 100 Mbps.

MPEG 4:
(4.8 64 Kbps).



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31


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video .
frames () I frames (Intracoded frames)
, Predictive frames P
(predictive) B (bidirectional) frames.

4.3.
(Twisted pair)

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: STP (Shielded Twisted Pair),
UTP (Unshielded Twisted Pair) FTP (Foiled Twisted Pair).
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Mbps .
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MHz.
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bit (10109bit/s 10Gbit/s 10Gb/s 10Gbps, Giga
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41



.
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FILE SIZE

2048 204812 bits

32 Mb

51251210 bits
1024102410 bits
4096512012 bits

160 Mb

51251212 bits

15 Mb


(CT)

(MRI)

25625612 bits50
images
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:
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1) .
2) (point to point).
DICOM

42

point to point .
client server.
3) (conformance levels) ,
.

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bandwidth

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Huffman coding run length.
JPEG
wavelet transform
(30:1) (mammography). O wavelet
transform

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laser .
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43

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Personal Computer (PC)


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( 256 Kbps).
Videoconferencing.


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5.9.

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44

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gamma correction
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45

4) :
6,3 9%.
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low power (
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video. video
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(.. e-mail).
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min.

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broadcast quality.
monitor
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10 25 min.

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48

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CCD
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57

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59

7.HOME CARE -HEALTH


T home care

, ,
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1% 30%
, 2020
80% .
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home care
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10.000 ,
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home care

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), ' ,
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.

(30-50%).
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home care,

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60

e- health

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(e-health).

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(Home telehealth home telecare).

:
() ,

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video ,
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61


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(wearable) (sensors),
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62

(home hospitalization)
(follow up - tele-monitoring)
(tele-rehabilitation)



(, )

(Hospice)


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63

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67


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GSM 9.6
kbps.

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GSM, High Speed Circuit Switched Data (HSCSD).
(time slots)
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14.4 kbps ( 50%),
43.3 kbps.
2G
2.5G {iDEN, 64 kbps; GPRS, 171 kbps; EDGE, Enhanced Data rate for GSM
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wideband code-division multiple access; CDMA2000, TD-, CDMA).
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1.


(DICOM - Digital Imaging and Communications in Medicine).
1983 (American College of
Radiology = ACR)
(National Equipment Manufacturers Association NEMA. DICOM,
.
, DICOM JPEG,
(lossless) JPEG-LS\

77

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MPEG.
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. ,
(region of interest = ROI)
, .
, 20%
15.1 JPEG-LS,
2.58.
,

.
,
.
lossless ,
( I, 2, 4096 ). ,
jPEG-LSa& lossless 2.58,
3.83 -lossless { I ). ,
20% ,
15.l 22.0.

2.
, DICOM
. MPEG-2
, MPEG-2
-
(frame synchronization'). -
ATM (Asynchronous Transfer Mode = ),
MPEG-2 ATM ,
(offline).

78


(realtime)
, ,
.
.

.


. '
38-128 kbps Dolby AC-2, MPEG-I Layer 2 (32-256
kbps) Dolby AC-3 (96- 768 kbps) . , -, .261( 64
kbps - 1.92 Mbps) .263 (15-64 kbps) .
,
-.
,
MPG4. MPEG-4
(time stamp) (frame).


.
, (bit rates)
,
.
,
. ,

. ,
,

(frames).
. , -
- -
, .

.
(interactive),
.


INSPEC MEDLINE
-: , (telemedicine & mobile)
GSM, (telemedicine & GSM) GPRS (telemedicine & GPRS).
(
)

79

1979 2001 132.



.
: GS, ,
(WLA).
, , , -, -, -,
' (
, '
). , 2,
:
() -, I ,
-, () ,
() () . 2
.
(18) GS 1999 2001.
(8),
- (4) - (3).
(12).
' (8)
(2) - (2).

. .
-
.
WL
-.

80

1: GSM

81

2: , .


,
,
-, -,
.

: Ambulance Emergency-112

1. :
-112
,
, "Ambulance",

.

82



. ,
, .. ,
, ..., .
(GSM) ,
,
.
,

,
.

Ambulance HCI00I Emergency-112 HC4027.
Ambulance

,
GSM.
,
. : (1)
, (2)
,
.
-, '


.
Emergency-112,
Ambulance,
.
- ( ECG,
BP, HR, SpO, ),
,
. - , .

, , GSM,
POTS ISDN. Emergency-112


(- ),
,
(user interface) .
. ,
.

( ).

83

.

(
).
(,
, )
' . Emergency-112
(, )
1998.

2.-
-

,
(whole-body spiral-computed-tomography scanner)
.
, ,
() -
, .
,
.
12
,
. ,
(C),
, , . server Sun Sparc 1000, RAID 7
209GB 21 ,
1728 X 2304, 1280 x 1600.
155 Mbps
() SD.
DICOM 3.0
.
10 16.5 .
19,117 29 .
75 ,
. ,
,
' .

(US$ 8,000,000),
, .
10
,
multi port format
.

84

3. : (MOMEDA)

,
. ,
,

( ).
,
/
, .

Momeda HC4015,
/DGXIII .
, (I)
(2) .

: Momeda



(Personalized Medical System-PMIS.
(customized)
, ,
(life-style)
.


,
, GSM.
Nokia Communicator
.
(server)
, (MR).
(, ,
).

85

4.: '
, ,
,
. '
(.. ) , ,
.
, ,
.

,
, , (
).
, '
.
, ,
' ,
,
.
-

GSM/WAP (WAP=Wireless Access Protocol). .
mobile agents .. Anglets workbench IBM,
Concordia Mitsubishi, Voyager,
. 'mobile agents'
.

. ,
.
(adaptive intelligent interface)
,
GSM
-.

: .

86


, video ,
.
,
.

.
,
' .

, on-line
.
,
,
.
, . ,
video
. bandwidth (
)
. bandwidth
,
. , video
MPEG ,
video
bandwidth.
Maryland
,
. :
,
.

. video,
.

: .

87

, , .

tablet
.
2-8
.

: .



video . video
,
.
( ) .
, bandwidth
.
(. ,
CO2, ) bandwidth,
video,
.
, modems
.
(Microsoft SQL).
(Microsoft Internet Information Server)
.

88


,
.


, video, ,
().
,
bandwidth ,

. (Wearable computers)

. ,
,
(. ). ,
,
,
.
.
3 (3G),

, . '
,
,
.



.

'
. , ,
.



CT (Information Communication & Technology)
,
,

.
: ,
89

( )
(VoIP: IP)
.
,

(ICT)
.
, , , , ,
.
, (switches,
routers, gateway) .

,

.


,
(ICT), :

: ICT.

,
, :
,
.

.
Internet ,

.

90

,
.


,
.
.

,
,
.

, ,
,
,
.
- Hardware
-
-
-

-
-

- .
-
,
.
- .


,
(Helpdesk)

: :

,
C . ,
.
,
.

.
1 .
, 2
.

,

. -
pervasive computing (

, ), -
(intelligent-agents),
, ,
-
.

91

11.

, .
,
,
(standards)

.



.


Food and Drug Administration(FDA),

,
() :
,
,
.




(, , , .).

.
(patient- centric)
.
,
. ,

92

, ,
.

(anywhere) (anytime).
,
. ,
.
:
:
(,
, .)
. ,
( )

.
:

. ,

.

,
(
).
: ,

(electronic patient record) .

(
),
.

(, minimum, data sets, ) .
. ,

( ) (
). , ,
.
,

.

,

93

(
) .



,

.

1. CENT/TC 251
CE (European Committee for Standardization)
.
CENELEC (
) SI(
), .
,
(Technical Committee TC)TC 251 C,

.

2. ACR
CR (American College of Radiology)
( )
, 30.000 .
ACR

.
www.acr.org.

3. HL7-Health Level Seven


HEALTH level Seven
SI (American National Standards Institute), 1987
2.000 ,
.
L7 ,

(L7 protocol)
.

4. IEEE
(Institute of Electronics Engineers) -
360.000
175 .
94


.
, 900
700 (standards .ieee.org).


802.11, ,
1073 .

5. American Telemedicine Association


(American Telemedicine AssociationATA) - 1993
.
, , ,

.
,
.
'
(telehomecare) - (telepathlogy), - , , .



.

( ) (low
bandwidth) , ,
ISDN .
( ) . ( )
(lossy compression)
.


( ) .
-
(lossless).
(standardized)
(proprietary). ,
ISO (International
Standards Organization) ITU (International Telecommunication Union).

JPEG (Joint Photographic Experts Group)
80 (' joint) ISO

95

ITU. JPEG
()
( )
( near-lossless algorithms). near-lossless
(teleconsulation),

. , JPEG2000
(WAVELETS).
JPEG2000 JPEG,
.
(region- ofinterest, ROI) ,
(lossless compression)
.


,

.

. 95/46
. 2472/1997

(
) .
97/66 . 2774/99
,

. , ,
,
.
,
,

. ,
,
.

CASE STUDY - '


'
,
( )
' .
VITAL -,
96

' .

.
3/12 , , ,
, , .
, ( )
C/. VIL-


.
monitor,

interface VIL.

DICOM Supplement 30
(
). (VITAL DICOM
Sup.30)

. VITAL

'
, , , , .

(common data architecture),
(Platform
Independent and Vendor systems) W3C consortium (World
Wide WEB Consortium) xml. H XML

.

97

12.

1.
,
, .
,
. ,
,

.
, ,
,
.
, '

. ,


.


,
(ISDN, GS,
, , )
, .
,

. ,
( )

, ,
,
. ,
:

(confidentiality) ,
.

98

, . ,
,
. (privacy),
, .

. ,
,
, .

, ,
.


(integrity) , , , .
, .. , , ,
. ,
.


(availability) ,
. ,
24 24-, , '
.
Denial
of Service (DoS attacks) (),

.


(Authentication service)
.
( user name),

.
,
.
:


(user authentication)
99

(data origin authentication)

(User authentication)
:




( )
(.. )
(..
(Personal Identification Number)
)

.
/ (challenge-response)
.
(challenge),
,
(response) .

,
,
.
challenge ,
,
response.
response ,
challenge. challenge
,
.

(Data origin
uthentication)
.

,
.


(non-repudiation)
(communication),
.

,
, , .
.

100

,
, ( ,
) ,
, .


,

.
' (firewalls),
,
(intrusion detection systems),
(backup), .
,
(identification) (authentication)
,
.


,
(, ,
) .

: .

usernames passwords,
,
. ,
(biometrics),
, , . '

101

, ..
.
( template
)
,
.

,

.
(digital certificates),
.

(Certification Authorities), .
,
(Health Professional Cards)
.

.
,

. ,
, .
( )
.

,
. ,
, monitoring, web , SSL, IPSec,
PGP, .
GSM.
, GPRS (3G),

.
(digital signatures).

,
. ,
,

. ,
e -mail

( ) .

102

: e-mail.

:


:
1. .
2. .
3.
.



.
,
(smart cards). ,
,
.



, (user profile).

.

.
.

103




.
.

. ,
.
.


:



(transaction log).
, /.



.
, .
(World Medical Association)
/ ,
. ,
International Conference of Medical Professionals
.

.

104



.
. , , .
, ,
( ) .

.

/

,
, .

,
. :
1. .
2. ,
.
3. .
4. .
5. .
6. .
7. .

105

2.

PKI (Public Key Infrastructure)



Internet.

. PKI
:


(Cs), ,
,
(domain).

(RAs),
(CAs)
.

(Certificate management
systems/CMS)
.
(CMS).

.500 (directories),


.

.
(trust relationship) .


(domains) .

(Trusted Third Parties).
,
(verified)
.
(PKI)
,
, .

- (digital timestamping services).
.


.

106

Internet ,

. Internet,
(e-mail address),
.
.

(open standards)
.

, ,
.

1.

(cryptosystem).
. ,
(encryption),
(plaintext) format, ,
(ciphertext).
, (decryption)
, .

. ,
.
(random bitvector). ,

, ,

. .
,
.
.

(confidentiality) .
, "" , ,
,
. .
( / public-key cryptography).


,
.

107

(confidentiality) ,
:
.
.
.
,

: .

DES [FIPS 462] (Data Encryption Standard), 1977 NBS


(National Bureau of Standards) FIPS 46.
O DES , 64
(64 bits). DES 56 (56-bit),
.
US$200,000.

. DES
hardware.
hackers ,
hardware,
.
.
triple-DES.
triple-DES 112 (112 bits),
. triple-DES DES
.


(publickey cryptography), .

108


.
.

. , (private key)
, (public key)
,
.
, .
,
.

: .



.
,

(session keys),

.


:





()

.


.
(
),
N(N 1)/2 , .

,
.
109


, .

.

.

:




.

.
.
(public key
certificates)
(directory).


(hash function)
,
(hash value).
,
.
,
.
(message digest).
,
(message digest
algorithms).
,
.
(oneway functions).
,

. ,

.

.

.

. :


MD5 (Message Digest Algorithm 5) RSA


Laboratories. O MD5 128 (128

110

bits).
MD5.
SHA-1 (secure hash Algorithm),
NIST (National Institute of Standards and Technology)
NSA (National Security Agency). O SHA-1
160-bit. MD5,
,
,
.

(public keys)
(authenticate user).

.

.

.
(certificate) [ISO 9594-8]
,
.
.

.
(Certification Authority)
.


:



"" .
""


:
1)
,
.
(message digest).

111

2)
.
3)
.
4)
.
5)
.
6)
.
 ,

.
 ,

.


.
.
PKCS-1 [PKCS#1],
RSA Laboratories .

,
. e-health
...
.

112



. ,
,
,
.
, ,
.

,
. ,
,
.
, ,
. ,

.
(.. ) , , .
. ,
(Risk Assessment)
(, , )
(, ).

. ,
, ()
,
. , ,
. ' ,
,

. , ,
, , .

113

13.

.

.
.

, , , ,
.
,
(VSAT - Very Small Aperture Terminal),
. ,

.

1960
.
.
.

.

.
,
, . ,
,
.

.
1945, Arthur Clarke
. 1950

114

,
,
.
, 1956
Echo ,
.

.
.

, ,
. Score 1958,
Courier 1960, Teslar 1962, Syncom1963. T 1964
. INTLESAT 1965.
1972
, INTERSPUTNIK. 1975

..- . 1977 ITU
, 1979

INMARSAT
(International Maritime Satellite erfanization ).
1981,
, 1982

. 1984 ,
, . 1987

INMARSAT, 1989-1990
.

.

. ,
,

.


.


.

115


:
1. O ,
, , ..
,
, :
ntelsat ( ) nmarsat
( ).
,
.
2. ,
, .
,
,
( ).

(Glbal sitining System) ,

24.
3. ,

.

,
.

, .
1994
"
".
4.
.
5. .
6. .
7. .
8. .

116

: .



. =23h 56min 4.1
sec. To 37786 Km.
3075 m/sec. ,
o .


.



. ,
,
,
.

i. T
, ,
, .
, ,
.

.

117


.

, , ,
, , (
), .

, . :


,
,
.


, ,
.
.

, ,



.
:


.
.

.

.
, ,

.

. .


,
.

.
.

118

.

.



.

.
Doppler .
,

.


.

.
42
, 10 .



.

,
.
.

: .

119



.
.

,
.
,
,

.
,
,
(),
.

.

.

, ,
.
,
.

.



,
. ,

. ,

.

,
.


.
:

120

,
.



( ).

:


121

(
)

.

,
,
.
,
. ,

.
.



, (.. ). ,
.
MSS (Mobile Satellite
System) :
(LEOs), 1000 km, (MEOs),
10000 km ,
(HEOs), . GEOs
INMARSAT-M, MSAT, ACTS, MOBILESAT
NSTAR. LEOs Iridium (66 770

122

km ), Teledesic (840 700 km). Odyssey


MEOs 12 10600 km
ELMSAT HEOs .


.

.

123

14.


(, , ),
.
.


,
, ,
.

:
, 42 .
, ,
. .

124

, .. ,
.
, .

:
,
. ,
.
. ,
.
(Histogram).
, ,
. , ,
.

125

:
, 87 , ..
2. ...
. , ,
.

:
... , ,
, AVF, V1-V5. , o
.

:
( 9 Boffors),
, . ,

, . 4
, , ...
6.
( )
, .

126

:
50 , , ..,
, .
:
. , .
.

:
,
, .
.

:
,
, .
. . ,
.
, 2 .
, ,
. , ,
. 2
.

127

15.

- :
:


,
.
,
, .
, , .
,
.





:
:







.

( ).
(patient record).
.
.
.


.

.
:




.
.

.
,
.

, .

128



,
,
.
:


,

.


,

.

(cross-check)
.


, , .

- .

,

,
. ,
,
.

129


,
,

. ,
, .
,

.

(, ),

,
.
,
.

. ,
.


, , .
, , , , ,
,

.

130

[1] , : , . , . ,
. .
[2] , : , . , .
[3] :
[4]
.
[5] :
.
[6] , : , . , .
[7] .
.
,
[8] .
,
[9] Guide to health Informatics , Enrico Coiera , Hodder Arnold
[10] Site : Mosbys Medical Encyclopedia

131

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