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H CH MINH
TRUNG TM CNG NGH HA
MN TIU LUN: HA HU C
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C$ Phng phaDp tEFng hGp aminoaxxitH0I$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$: 0$Jmin hoDa caDc haKogLn axit$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$: 9$ Phng phaDp L#tL phtaKimidoKaonic$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$5 M$ Phng phaDp xianhidNin$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$1 4$ Phng phaDp 2icLKKanLu#$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$O :$ PhF caDc hGp chQDt nitNo, oxim ha" hiddNaRon cuFa STandLhitaxit ha" ST xLtoaxit$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$O 5$ TaDc duGng L#tL axLtoaxLtic th D vDi muEDi phLn"KdLaRoni$$$$$$$$$$$$$$$$$$$$$$$$$$03 U$ <EGng ammoniac vaVo axit cha no$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$03 1$ +G phQn giaFi caDc hGp chQDt aminoaxit Wuang hoaGt$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$03 CC$Phng php iu ch axit cacXox"KicH0I$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$00 0$Phng php oxi h/a$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$09 9$ Phng php thuY phQn$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$0M M$ Phng php cacXon"K h/a$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$04 4$ TZng h[p L#tL axLtoaxLtic v x"anaxLtat$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$0: :$ TZng h[p t\ L#tL moKonat$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$0: 5$ TZng h[p t\ iaRomLtan$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$05 U$ Ph!n ]ng chu"^n v_ m`ch cacXon$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$05 CCC$ Phng php tZng h[p dn xut ca axitH0I$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$05 0$ a#tL $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$05 9$ 8aKogLn axit$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$01
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</ Kf Nt nhiu ng*i bhEng Xit n axit hgu c haxit cacXox"Kici ha" amino axit K gj nhng th,c Na hk c/ th^ l t\ng gmp v #n deng nh gim K axit axLtic, axit oomic tNong bin vng ha" XBt ngkt K axit gKutamic$ %/i thLo cch bhoa hkc thj Jxit cacXox"Kic K cc h[p cht hgu c tNong phQn tn c/ nh/m cacXox"K hT<pp8i Ki n bt tN,c tip v7i gqc h"dNocacXon$ 8a" n/i cch bhc axit cacXox"Kic K dn xut ca hidNocacXon bhi tha" th 0 homc mBt vi ngu" n tn 8 Xrng nh/m cacXox"Ks ctn Jmino axit K h[p cht t`p ch]c ch]a hai nh/m ch]c K amino v axit tNong phQn tn hidNo cacXon m`ch h@, m`ch vtng ha" thm Ko`i XLnRoit ha" thm d_ vtngH0I$ PhEng chu K #n deng Km XBt ngkt ha" gim m hai axit tN n ctn nhiu hgu =ch bhc tNong cuBc #qng cvng nh nghi n c]u bhoa hoc$ <hwng h`n v axit cacXox"Kic: Jxit axLtic cvng [c #n deng tNong #!n xut thuqc nhuBm bhc nhau cht Ki-u, n7c hoa v Na"on, cht Km Eng te tNong #!n xut cao #us Jxit hgu c [c #n deng cho vi-c chuxn X_ ca nhiu Ko`i thuqc nh a#piNin, phLnacLtins Jxit hgu c [c #n deng tNong th,c phxm, ; uqng K`nhs Jxit Xyo cao hn [c #n deng tNong #!n xut x phtng$ ' amino axit: Jxit amin K c,c bz Wuan tNkng cho #, t;n t`i ca #, #qng v ch{ng c/ mBt vai tNt Wuan tNkng tNong tNao Zi cht ca mBt #inh v|t, thiu aminoTaxit tim X_ tn cEng, Bt Wuc v cao hu"t p,$$ axit amin c/ tNong th_t K[n, #ga, pho mt, nho, da hu, #{p K, bhoai Kang, cAn tQ" v g`o$ Jxit cacXox"Kic v amino axit c/ #}n tNong cc Ko`i th,c phxm, ; d~ng ha" ; uqng nhng ^ c/ [c cc cht / thj ph!i d~ng cc phng php tZng h[p t\ cc cht bhc nhau @ phtng th= nghi-m ha" tNong cEng nghi-p$ <h=nh vj cc axit [c ]ng deng nhiu tNong cuBc #qng m hEm na" tEi c|p n cc phng php iu ch axit, aminoaxit v dn xut ca n/ do cc nh bhoa hkc nghi n c]u ^ tZng h[p n n cc cht phec ve *i #qng con ng*i v mec =ch nghi n c]u bhoa hkc$
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Jminoaxxit KaV hGp chQDt taGo chDc chDa hai nhoDm chDc amin vaV axit tNong phQn tF hiddNocacXon maGch hF, maGch voVng ha" thm KoaGi XLnRoit ha" thm diG voVng$ +ong aminoaxxit phEF Xi Dn nhQDt tNong tG nhi n KaV aminoaxit maGch hF:
PhaFn Dng tN n duVng F tEFng hGp caDc aminoaxit nh , S, ,tV dan xuQDt haKogLn tng Dng:
+ong duVng F tEFng hGp caDc STaminoaxxit thuQGn KGi hn vj t=nh XaR cuFa amino axxit hiVnh thaVnh nhoF hn tiDnh XaRo cuFa taDc nhQn Xan QVu nhi Vu$ :
<aDc haKogLn axit thVng i Vu ch D X(Vng haKogLn hoDa axit bhi coD P ho(Gc X(Vng phng phaDp tEFng hGp L#tL maKonic:
Phng phaDp tEDt hn KaV duVng phaFn ]ng anb"K hoDa L#tL %Tth D cuFa amonimaKonic F i Vu ch D tV XNom hoDa iLt"KmaKonat thLo +%9:
a#tL naV" d anb" hoDa tNong bi Vm ha" hGp chQDt cacXon"K , STcha no$ ThuF" phQn caF hai nhoDm L#tL vaV phtaKimit tNong axit maGnh NEVi LcacXox"K hoDa$ +aFn phQFm thu Gc KaV STaminoaxit NaxLmic hoDa:
<h(Fng haGn:
8i Gu WuaF phaFn Dng tEDt hn n Du duVng dQn xuQDt %TaxLtamit tha" cho phtaKimit$ F Q" #aFn phQFm %TaxLtamit Gc i Vu chL# X(Vng nitNoRo hoDa axit maKonic, chu" Fn viG oxim vaV bhF:
a#tL axLtamidomaKonic c1ungx d anb"K hoDa vaV #aFn phQFm anb"K hoDa cung Gc thuF" phQn vaV LcacXox"K hoDa nh tN n:
PhaFn Dng coD th F ti Dn haVnh tNong hEn hGp anLhit, ammoniac vaV 8<%thLo phaFn Dng +tNichLN Wua giai oaGn hiVnh thaVnh STamonitNin:
PhaFn Dng i Wua #aFn phQFm imin cEGng hGp vDi 8<%:
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Taminoaxit cung coD th F thu Gc X(Vng caDch bhF xuDc taDc axit xLtocacXox"Kic X(Vng 89 bhi coD %8M:
% Du duVng caDc hGp chQDt nitNo ha" oxim cung nh hiddNaRoncuaN caDc anLhit ha" xLtoaxit F viG tNiD xa hn cung thu Gc caDc S,tng Dng$ O
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Phng phaDp bhaDc F phQn giaFi aminoaxit KaV phQn giaFi #inh hoGc, tng tG #G ti u thuG choGn KoGc cuFa c th F #inh vQGt, nghia KaV WuaD tNiVnh phQn giaFi X(Vng mLn coD tNong #inh vQGt$ II.P$%&'( )$Q) R1S@ 7$T *31, 7*7U23E817456
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%u i t\ ancoK, ph!n ]ng bhEng d\ng K`i @ giai o`n anLhit vj ph!n ]ng oxi h/a anLhit d& hn ancoK:
Phi oxi h/a h[p cht ch]a nqi Ei, muqn X!o ton nqi Eic/ th dung tc nhQn oxi h/a "u hn Jg9p:
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Ph!n ]ng oxi h/a x!" Na @ <S v bhi phQn tn ctn c/ 8S$
TNong th,c nghi-m,th*ng i t\ dn xut haKogLn cho tc deng v7i x"anua natNi N;i th" phQn, thu [c axit t(ng mBt m`ch cacXon #o v7i xut haKogLn:
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Phng php GNignaNd n" dung th=ch h[p cho dn xut haKogLn bhEng c/ bh! n(ng ph!n ]ng thLo +%9$ n xut haKogLn X|c nht ha" X|c hai bhEng c/ m`ch nhnh thj ph!n ]ng u vi-t hn$ ioxit cacXon cvng ph!n ]ng tqt v7i c 6iti:
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2uqi ca axit cacXox"Kic cvng thu [c bhi cho oxit cacXon ph!n ]ng v7i bim ha" ancoKat d7i ap#uaat# 5 atm @ 093T0M3o<:
Ph!n ]ng c/ ngh.a b ngh- K tc deng oxit cacXon v7i Lt"KLn ha" oKLoin v n7c bhi c/ x{c tccacXon"K nibLn:
</ th^ cho tc deng oxit cacXontNong axit #~nuNic mc v7i nibLn nh K ph!n ]ng anb"K h/a oxit cacXon:
Ph!n ]ng ca axLtoaxLtat x!" Na v7i ph!n ]ng c`nh tNanh t`o thnh xLton
Ph!n ]ng d~ng tZng h[p cc axit anb"Kha" ianb"KaxxLtic v cc axit cha no phe thuBc vo gqc ca dn xut haKogLn$
8omc Xrng chu"^ v_ S haKogLnxLton thnh axit bhi tc deng v7i bim:
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Phng php d~ng ^ tZng h[p bhEng qi x]ng$ </ th^ d~ng tN,c tip axit:
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TN n Wuan i^m ca mBt nh h/a hkc cEng nghi-p, mBt i^m ng ch{ K cc vi bhuxn acLtogLn c/ th^ t`o Na axit axLtic t\ cc h[p cht ch]a 0 cacXon nh incKuding mLtanoK, cacXon mEnEx=t, ha" hn h[p ca cacXon dioxit v h"dNo:
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Ph! n(ng Clostridium chu"^n h/a tN,c tip cc Ko`i *ng homc t`o Na axit axLtic v7i chi ph= Au vao thp, c/ ngh.a Nrng cc vi bhuxn n" c/ th^ c/ bh! n(ng t`o Na axit axLtic hi-uWu! hn phng php Ex" h/a LtanoK nh Acetobacter$ Tu" nhi n, vi bhuxn Clostridium =" ch_u axit hn Acetobacter$ %ga" c! hAu ht cc chng Clostridium ch_u axit nht c/ th^ t`o Na gim chu `t vi phAn tN(m axit axLtic, #o v7i cc chng Acetobacter c/ th^ t`o Na gim v7i n;ng B axit K n n hn 93$ 8i-n t`i, chi ph= ^ #!n xut gim Xrng Acetobacter vn cao hn d~ng Clostridium v #au / tch n/$ Pt Wu! K, mmc d~ vi bhuxn acLtogLnic l [c Xit n NBng Nli t\ n(m 0O43, vi-c #n deng @ Wu" mE cEng nghi-p ca Ko`i vi bhuxn n" vn ctn gi7i h`n tNong mBt vi ]ng deng$H0OI
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u tNjnh n" Ki n Wuan n cht tNung gian iodomLtan, v di&n Na thLo M X7c$ <ht x{c tc, th*ng K ph]c cht bim Ko`i, [c d~ng tNong X7c 9$
v|t Ki-u c/ th^ ch]a cc h[p cht gQ" (n mtn @ p #ut cao hbho!ng 933 atm homc hni l bhEng [c bhu"n bh=ch thng m`i h/a phng php n"$ Phng php cacXon"K h/a mLtanoK thng m`i Au ti n, #n deng cht x{c tc coXan, l [c cEng t" h/a cht ]c )J+ pht tNi^n n(m 0O5M$ %(m 0O51, cht x{c tc gqc Nhodi hcisHhh<pi9C9Ii [c pht hi-n c/ th^ v|n hnh mBt cch hi-u Wu! @ p #ut thp m hAu nh bhEng c/ #!n phxm phe$ %h m" Au ti n #n deng cht x{c tc n" [c cEng t" h/a cht 8oa Pz 2on#anto xQ" d,ng n(m 0OU3, v cacXon"K h/a mLtanoK v7i x{c tc Nhodi tN@ thnh mBt phng php phZ Xin d~ng ^ #!n xut hxLm cEng ngh- 2on#antoi$ 'o cuqi th|p ni n 0OO3, <Eng t" h/a cht )P thng m`i h/a cht x{c tc <ativa hHCNh<pi9C9Ii, [c cht t\ NuthLni$ <Eng ngh- <ativa d~ng cht x{c tc iNidi n" #`ch hn v hi-u Wu! hn v l tha" th phAn K7n cEng ngh- 2on#anto, th*ng d~ng tNong c~ng mBt nh m" #!n xut$
thng h n/ng tN7c bhi nho l ch=nh v #}n #ng ^ #!n xut N[u vang$ Phng php n" ch|m, tu" nhi n, bhEng ph!i K{c no cvng thnh cEng, bhi nhgng ng*i Xn N[u bhEng hi^u Wu tNjnh n"$ 2Bt tNong nhgng cEng ngh- thng m`i hi-n `i Au ti n K phng php nhanh homc phng php ]c, l [c ]ng deng @ ]c n(m 019M$ TNong phng php n", Wu tNjnh K n mLn di&n Na tNong mBt thp Xkc Xrng g Xo homc than$ <c cht cung cp c;n [c cung cp t\ tN n unh thp, v bhEng bh= #`ch [c cung cp t\ d7i K n Xrng thEng bh= t, nhi n homc Xn qi Ku$ 'i-c cung cp bhEng bh= [c c!i thi n tNong Wu tNjnh n" Km gi!m X7t th*i gian iu ch gim t\ vi thng ctn vi tuAn$ %g" na", hAu ht gim [c #!n xut tNong cc th~ng ^ ngAm [c ptto 8Nomatba v 8LinNich aXnLN #n deng Au ti n n(m 0O4O$ TNong phng php n", N[u [c K n mLn thnh gim tNong X;n [c !o Ki n tec, v Ex" [c cung cp Xrng cch thZi Xkt bh= Wua dung d_ch$ +n deng cc ]ng deng hi-n `i ca phng php n", gim ch]a 0: axit axLtic c/ th^ [c u cht tNong vtng 94 gi*, th|m ch= `t [c B gim 93 tNong vtng 53 gi*$
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$Jxit axLtic K mBt cht ph!n ]ng [c d~ng ^ #!n xut cc h[p cht h/a hkc$ 6[ng #n deng Ni ng K K7n nht K ^ #!n xut momonLN vin"K axLtat, tip thLo K #!n xut axLtic anh"dNit v L#tLN$ 6[ng axit axLtic d~ng ^ #!n xut gim K Nt nh #o v7i @ tN n$ M2'209 K1'E8 *39,*, dng deng ch "u ca axit axLtic K #!n xut monomL vin"K axLtatL$ dng deng n" ti u the bho!ng 43 n 4: #!n K[ng axit axLtic tN n th gi7i$ Ph!n ]ng c/ #, tham gia ca Lt"KLnv7i Ex" v cht x{c tc K paKKadi$
94
'in"K axLtatL c/ th^ [c poK"mL h/a t`o thnh poK"vin"K axLtat homc thnh cc poK"mL bhc ]ng deng tNong #n v cht bt d=nh$ Ob' 3@Y, 9;,9 <c L#tL ch=nh #!n xut t\ axit axLtic [c #n deng ch "u Km dung mEi cho m,c, #n vcht ph$ <c L#tL nh Lth"K axLtat, nTXut"K axLtat, i#oXut"K axLtat, v pNop"K axLtat, ch{ng [c #!n xut mBt cch mc Xi-t Xrng ph!n ]ng c/ x{c tc t\ axit axLtic v N[u tng ]ng:
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JxLtic anh"dNit K mBt cht acLt"K h/a m`nh$ 'j v|", ]ng deng ch=nh ca n/ K t`o cLKKuKo#L acxtat, mBt cht d-t tZng h[p cvng [c d~ng tNong phim chep !nh$ JxLtic anh"dNit cvng K mBt cht ph!n ]ng d~ng ^ #!n xut a#piNin, hLNoin, v cc h[p cht bhc$ G1Y0 d`ng gim, cc dung d_ch axit axLtic hn;ng B bhqi K[ng ca axit 4 n 01i [c d~ng tN,c tip Km gia v_, v cvng Km cht tNBn Nau v tNong cc th,c phxm bhc$ Gim (n htaXKL vinLgaNi thj Kolng hn h4 n 1i, tNong bhi Ko`i gim tNBn thng m`i thj n;ng B cao hn$ 6[ng axit axLtic d~ng Km gim bhEng chim tu K- K7n tN n th gi7i, nhng K mBt ]ng deng nZi ting v [c d~ng t\ Nt KQu$ LZ0 <@'( 0-1 Jxit axLtic X(ng K mBt dung mEi pNotic phQn c,c tqt nh c|p @ tN n$ %/ th*ng [c d~ng Km dung mEi ti bt tinh cho cc h[p cht hgu c tinh bhit$ Jxit axLtic tinh bhit [c d~ng Km dung mEi tNong vi-c #!n xut axit tLNLphthaKic hTPJi, mBt ngu" n Ki-u thE ^ #!n xut poK"Lt"KLn tLNLphthaKat hPaTi$ %(m 9335, bho!ng 93 axit axLtic [c d~ng ^ #!n xut TPJ$ Jxit axLtic th*ng [c d~ng Km dung mEi cho cc ph!n ]ng Ki n Wuan n cacXocation, nh NiLdLKT<Naot# aKb"Kation$ '= de, mBt giai o`n tNong #!n xut Kong nlo tZng h[p thng m`i Ki n Wuan n #, ti #p xp agnLNT 2LLNLin ca t`o amoLn i#oXoNn"K axLtats @ Q" axit axLtic /ng vai tNt v\a K dung mEi, v\a K cht i nhQn ^ gig caNXocation ti #p xp$ Jxit axLtic K dung mEi t, chkn bhi gi!m mBt nh/m nit aN"K t`o aniKin Xrng cch #n deng cacXon mang paKKadi$ 95
Jxit axLtic X(ng [c #n deng tNong h/a phQn t=ch ^ 7c t=nh cc cht c/ t=nh bim "u nh cc amit hgu c$ Jxit axLtic X(ng c/ t=nh XaR "u hn n7c, vj v|" amit ]ng xn nh mBt XaR m`nh tNong dung d_ch axit tNung Xjnh n"$ +au / n/ c/ th^ [c chuxn B Xrng cch #n deng mBt dung d_ch axit axLtic X(ng ca mBt axit Nt m`nh nh axit pLNcKoNic$ CQ7 c'( <i'( [$Q7 <c axit axLtic Kolng cvng [c d~ng t`o B chua nh$ '= de nh tNong Wu" mE gia jnh, n/ [c d~ng Km cht tx" cmn vEi t\ vti n7c v m un n7c$ <c dung d_ch axit axLtic X(ng Kolng c/ th^ [c d~ng tNong cc phtng th= nghi-m KQm #ng ^ dung gi!i cc h;ng cAu cvng nh m X`ch cAu$ 2Bt ]ng deng KQm #ng bhc K dung gi!i cc h;ng cAu, m c/ th^ Km m* cc thnh phAn Wuan tNkng bhc tNong n7c ti^u bhi phQn t=ch d7i b=nh hi^n vi$
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