TRANG BA. TRANG MC LC. NI DUNG. I. Khi qut v Fucoidan. 1. Gii thiu v Fucoidan.

Vo 1913, mt loi polysaccharide c tm thy bi Gio s Kylin ca i hc Uppsala Thy in l ngun cht nhn t kombu (kombu l mt loi to gi theo tn ca Nht bn) y l mt loi fucan. Ban u cht ny c tn vit tt l Fucodin. 40 nm sau, Fucoidin c i thnh Fucoidan cho ng vi tn gi ca polysaccharide. Do c hot tnh sinh hc cao, Fucoidan nhanh chng c cc nh khoa hc ch quan tm. Gn y, chc nng sinh hc a dng ca Fucoidan c nghin cu chuyn su hn. Fucoidan c mt trong thnh t bo ca cc loi rong nu ch yu thuc b (Order) Laminariales v b Fucales ca lp (class) Phaeophycese. (TLTK: Tp ch khoa hc v cng ngh - tp 45, s 1, 2007.) Bng: mt s loi rong nu c hm lng Fucoidan cao (trch t: bng 1-tp ch khoa hc v cng ngh- tp 45, s 1, 2007) TT 1 2 3 B Loi

C 3 loi Fucoidan l f- Fucoidan, u- Fucoidan, g-Fucoidan. Trong 3 loi ny, uFucoidan l loi c quan tm nhiu nht. l do cc nghin cu chng minh trong u-Fucoidan c cht lm cho t bo ung th trong c th con ngi t hy dit. U-Fucoidan c nhiu trong cc loi to bin nh kombu, mozuku, hijiki, trong cc phn t ng n nh glucuronic acid, mannoza (C6H12O6), fucose (C6H 12O5) ng cnh nhau. (TLTK:http://en.wikipedia.org/wiki/Fucoidan, http://www.secviet.cz/anhqc/star/sontri.htm) 2. Thnh phn v cu trc ha hc ca Fucoidan. Fucoidan l mt chui cao phn t polysaccharide v c thnh phn chnh l sulfate fucose. Ngoi fucose, thnh phn chnh ca Fucoidan cng bao gm galactose, mannose, xylose v axit uronic. Tn gi "Fucoidan" hin ti khng c cu trc nht nh, nhng n l mt thut ng chung cp n chui phn t cao polysaccharides c thnh phn chnh l fucose (C6H12O5). Cu trc ca Fucoidan ging vi cu trc ca chondroitin sulfate, c mch thng vi n. C cu trc (16)--D-galactose hoc (12)--D-mannose, c phn nhnh ti v tr (13) hoc (14)--L-fucose, (14)--D-glucuronic acid, -D-xylose u cui v i khi (14)--D-glucose. Cc dng cu trc in hnh vi lin kt (13) ca Fucoidan. (TLTK: Tp ch khoa hc v cng ngh - tp 45, s 1, 2007)

Cng thc cu to ca Fucoidan (trch: http://www.thuocFucoidan.com/cau-chuyen-Fucoidan/su-that-ve-thuoc-triung-thu-Fucoidan.html) 3. Tnh cht ha l ca Fucoidan. Fucoidan c trng lng phn t khng ln. Trng lng phn t ph thuc vo qu trnh chit tch do s s dng cc ha cht khc nhau. Cc tc nhn khc nhau s dng trong qu trnh chit tch c th gy nn hiu ng gy mch polysaccharide. Do , t mt loi rong c th thu c cc phn on vi trng lng phn t khc nhau. Khi h axit ca dch chit ti 2.0 d k ta Fucoidan t Hizikia fusiformis, ngoi phn on c trng lng phn t 105 kDa cn thu c phn on c trng lng phn t 26 kDa.

II.

Ph hng ngoi ca phn on polysaccharide chit tch khc t Fucus Vesiculous cho thy hp thu ca nhm sulfate c c trng mt s nh 820 cm-1, 844 cm-1 (ti C-4 ca fucose), 1225-1255 cm-1, 1425-1,1730 cm-1. Ph 1H NMR ca fucan cho thy di c cng mnh 1,4 ppm l do 6deoxisugar proton tao nen, tng ng vi sugar trung tnh chnh trong fucanfucose. Fucoidan c cng nht khng cao lm. cht khng cao chnh l do polysaccharide ny cht t cc loi rong nu khc nhau thng c mch khng di v trng lng phn t khng ln. Fucoidan c tnh cht ha hc c bit, tnh cht lu bin khi nhit thay i. (TLTK: Tp ch khoa hc v cng ngh - tp 45, s 1, 2007) 4. Hot tnh sinh hc ca Fucoidan. Ging nh Heparin sulphat, Fucoidan c hot tnh sinh hc rt cao, c nhiu tnh cht sinh hc khc nhau nh chng khi u, tng cng min dch chng khng b th, chng oxy ha, chng ng mu, chng to huyt khi, chng s pht trin v bm dnh t bo. Fucoidan c tc dng bo v t bo chng nhim khun. c bit l hot tnh chng ung th. - Fucoidan hn ch s pht trin ca t bo ung th. - Tnh cht khng khun, khng virut ca Fucoidan. (TLTK: Tp ch khoa hc v cng ngh - tp 45, s 1, 2007) Mt s cng dng ca Fucoidan. Fucoidan l mt hot cht thin nhin c kh nng tng min dch, git t bo ung th, gii c v gim au. Fucoidan c bit n nh mt sn phm c ngun gc t t nhin thu ht s ch v quan tm ca cng ng y t nh l mt cht c kh nng cha bnh t nhin v iu tr ung th hiu qu ngn nga v iu tr bnh tt. Hin nay Fucoidan khng c xem l thuc m ch l mt loi thc phm dinh dng. Theo nhiu nghin cu v th nghim pht hin ra rt nhiu cc chc nng ca Fucoidan: 1. Gim hm lng Cholesterol: Fucoidan c kh nng qun l cholesterol ca c th gip chng ta c th kim sot trng lng ca mnh. Cht t nhin ny t chy i axit bo nh cholesterol v triglycerides. Fucoidan cng gip c ch qu trnh m trong v to ra cc axit bo. S liu t phng th nghim Laboratory of Lipid Chemistry in Yokohama, Nht bn cho thy rng nhng con chut n rong Nu c mc m mu thp hn ng k so vi nhng con chut khng n rong. Sau 21 ngy nghin cu s dng rong bin cc nh khoa hc a ra c kt lun rng cc hp cht trong rong Nu s lm thay i hot tnh ca cc enzymes trong gan v kim sot cc axit bo c chuyn ha, dn n mc cholesterol trong mu thp hn. Cc nh nghin cu khc ca Nht Bn tin hnh mt nghin cu khc trong cc i tng kim tra c cho n mi ngy 5g rong bin c cha Fucoidan trong 3 tun. Kt qu, huyt p v mc cholesterol cao ca h c ci thin ng k. Cc kt qu nh vy c cng b cho World Health Organization (WHO) v h khng nh rng thnh phn Fucoidan ca mt s thc vt bin xc tin vic t cht bo trong gan v h tr v bo v h tim mch. ng thi Fucoidan cn ti u ha cc mc ca HGF (hepatocyte growth factor - thng s pht trin t bo gan) trong gan m cholesterol c to ra v cc axit bo c tng hp. Hn na, r rng

l Fucoidan c th ngn chn s to thnh cc cc mu ng, lm gim ri ro cc cn au v t qu tim. (TLTK:http://www.sieuthiyensao.com/xem/fucoidan-cholesterol-va-cao-huyet-ap-highblood-pressure-191/

http://translate.googleusercontent.com/translate_c?depth=1&hl=vi&prev=/search%3 Fq%3DFucoidan%26start%3D20%26sa%3DN%26biw%3D1366%26bih%3D642&r url=translate.google.com.vn&sl=en&u=http://www.Fucoidanextract.com/Fucoidanseaweed&usg=ALkJrhizX8pkcxB6BstjjVSjwoxPp2DPuw) 2. phng nga bnh d ng: Mt nguyn nhn m nhiu ngi au kh t bnh d ng l h thng min dch ca h nhn bit sai cc cht nh phn hoa, bi hoc cc cht khc nh vi sinh vt thm nhp t bn ngoi vo, h min dch ca chng ta sn xut ra cc cht c gi l IgEs gy ra ht hi, th kh kh, vim mi v cc triu chng khc. Cc cht d ng c th gy ra vic sn xut qa mc IgE. Thnh phn ca Fucoidan cung cp mt cng thc dinh dng cn bng h tr gn nh tt c cc c quan trong c th. Do Fucoidan kch thch s ti sinh t bo nn c th lm tng tng s cc t bo trong h min dch. Tc dng ny gip tng cng kh nng ca c th chin u vi bnh tt v cn c th lm gim nh hng cc phn ng min dch. Thc ra, mt s nghin cu ti Department of Agriculture at Ryukyu University in Japan pht hin ra rng Fucoidan hot ng theo mt s cch khch thch cc phn ng min dch dng trong c th con ngi. Chng hn, cc nh khoa hc by gi bit rng Fucoidan trong Limu Moui (Limu Moui l mt thnh vin ca gia nh rong Nu c ngun gc Tonga) c th kch thch vic sn xut interleuuap1 v interferon-fA (cc protein c tit ra bi cc t bo min dch) dn n vic ngn chn sn xut tha IgEs (gy ra nhiu triu chng d ng). Trong mt th nghim: tim chng chut vi mt loi albumin tng tc nh mt d ng nguyn. Nhng con chut no c x k bng cho n Fucoidan c mc IgEs gim ng k. kt qu l cc hin tng phn ng d ng l gim hn ng k . (TLTK:http://www.sieuthiyensao.com/xem/fuocidan-va-phong-ngua-benh-di-ungallergy-prevention-190/)

3. Cn bng h min dch: Qu trnh lo ha, cc tc ng ca cc yu t nh s dng thc phm khng an ton, tc ng xu ca mi trng do cc cht ha hc, s cng thng, mt mi l nhng nguyn nhn gy ra s suy gim min dch ca con ngi. S suy gim min dch khin vic loi tr cc t bo d thng khng trit v cc t bo d thng cn st li s pht trin thnh ung th. Cc nghin cu cho thy Fucoidan c kh nng lm tng s ti to cc t bo min dch v nng cao qu trnh sn sinh cc cht c hot tnh sinh hc. Hot ng hp lc ca nhiu loi t bo min dch c hot ha bi cc cht c hot tnh sinh hc c gia tng v s lng v cht lng gip tng kh nng min dch tn cng v chng li cc t bo ung th. Fucoidan c kh nng kch thch s min dch trong rut, mt b phn then cht v ln nht cung cp s min dch cho c th chng ta. Kh nng kch hot min dch ng rut ca Fucoidan c to ra bng cch hot ha hiu qu cc limpho bo trong qu trnh chng tn cng vo chnh Fucoidan ti rut. Kt qu l c th ca chng ta lc no cng duy tr c kh nng min dch cao chng li cc mm bnh, vi rt... v c cc t bo ung th d thng.

(TLTK:http://www.sieuthiyensao.com/xem/fucoidan-nang-cao-mien-dich-tieu-diet-ungthu-116/)

4. tng min dch c bn: Cc h thng min dch ca chng ta nm di s tn cng khng ngt v cc ri lon min dch. Cc nghin cu mi y lin tc xut hin quan im cho rng s trc trc min dch nh l nguyn nhn gy ra bnh tim v nhiu loi x cng m. Cc tnh cht mnh m ca Fucoidan lm cho n tr thnh cht b sung tuyt vi h tr min dch. Thc ra cc nh khoa hc so snh s kch thch h min dch ca Fucoidan vi cc cht c cung cp bi sa m. Thnh phn Fucoidan ca Limu Moui lm vic theo cch rt ging ca sa m. Thnh phn sa m tun u tin rt ging Fucoidan, mt thnh phn chnh ca rong Limu Moui tc thn tin. Cc tr em mi sinh khng c cc khng th cn thit cho s sng cho n ht tun u tin v trong sut thi gian m tr pht trin mt h min dch. Theo Dr.Kyosuke Owa, mt chuyn gia v rong Nu cho rng Fucoidan cha cc dng khng th tng t c tm thy trong sa m, do cung cp cc cht dinh dng lm tng h min dch. Cc nghin cu khoa hc ca Dr.Owa cho thy rng Fucoidan kch thch s sn xut t bo min dch cn cho s sng, gip cho c th c c v kh tt hn c kh nng chng li nhng k th cht ngi nh vi khun, virut, nm, k sinh trng v ngay c cc t bo ung th. (TLTK: http://www.sieuthiyensao.com/xem/fucoidan-chat-lam-tang-mien-dich-co-ban195/)

5. Fucoidan ngn chn vim phc mc: Vim phc mc l mt hi chng bnh do nhiu nguyn nhn gy nn. Vim phc mc l giai on cui ca cc bnh nhim khun trong bng, l phn ng vim ton b hoc mt phn ca phc mc do vi khun hoc do ha cht. Cc tnh cht khng vim ca Fucoidan cn c th gip cha cho cc trng hp vim. Cc nh khoa hc ti Institute of Biomedical Chemistry of the Rusian Academy of Medical Sciences in Moscow cng b trong nm 1997 rng Fucoidan thc t c th c ch qu trnh vim tham gia ngn chn vim phc mc (c th l mt bin chng nghim trng do vim let thng d dy gy ra). H pht hin ra rng s c mt ca Fucoidan ngn chn vim ca cc t bo bch cu gy ra, bng cch di tr v mt im nh vy m lm gim vim do cc phn ng vim nhim. vim phc mc l nguyn nhn ca nhiu ri lon mn tnh bao gm cc dng vim khp, d ng v ri lon d dy, do tc dng ny ca Fucoidan l rt c ngha. (TLTK:http://www.sieuthiyensao.com/xem/fucoidan-ngan-chan-viem-phuc-mac-vaphuc-hoi-co-the-nhanh-194/

http://yduocvn.com/?x/=newsdetail&n=4491&/c/=98&/g/=24&/9/6/2010/hoi-chungviem-phuc-mac.html) 6. Fucoidan gip hi phc c th nhanh chng: Fucoidan xc tin s phc hi c th nhanh hn v n kch thch s ti to t bo gan tt hn. Thc ra, mt nghin cu pht hin ra rng b sung Fucoidan qua ng ming hai ln mi ngy cho cc ng vt th nghim phng th nghim y mnh s phc hi gan. Chc nng gan khe mnh gip tng cng th lc ton b c th. i vi nhng ngi c bnh mn tnh, b tn thng do tai nn, hoc b phu thut, vic b sung Fucoidan c th lm tng tc phc hi. Fucoidan khng

ch kch thch s thay th cc m trong gan, m cn trong cc c qu an khc bao gm c da. Thc ra, kh nng kt hp ca cc khong keo vi thnh phn Fucoidan ca Limu Moui gip kh nng c th i ph vi s cng thng. Vic tit ra Cortisol (Cortisol l mt loi hooc mn corticosteroid) trong sut cc giai on b cng thng c th dn ti bnh v lm suy yu h min dch, nhng bng cch cung cp u cho c th cc hp cht phc hi v cc khong cht c tm thy trong Limu Moui, th ta cung cp mt tm chn bo v khi cc tc dng nguy hi ca cng thng. (TLTK:http://www.sieuthiyensao.com/xem/fucoidan-ngan-chan-viem-phuc-mac-vaphuc-hoi-co-the-nhanh-194/)

7. Ngn nga qu trnh lo ha v thn thin vi da t trong ra ngoi: Cng b cn khng nh rng Fucoidan thc y s co ca collagen gel, m gip tng cng s phc hi vt thng. Cc hp cht rong bin khc cng gip chng s kh m gy ra s gi sm. Thc ra, cc dch chit keo rong bin thng c s dng trong vic lm mm da v lm tc. Th nghim cc ng vt th nghim ch ra rng ng dng dch chit rong Nu (vi hm lng Fucoidan cao) trong mt vi tun lm cho da cng hn. iu khng nh rng cc hp cht rong Nu thc ra lm ngn chu k m trong cc t bo da t thay th. Lm nh vy da s chm b nhn hn v khi phc nhanh hn. Mt s tc dng bo v da ca Limu Moui c th l do thnh phn axit alginic ca n. Axit alginic gip gi thc vt khi b kh do s phi khc nhit di tia t ngoi ca mt tri. Thc ra dch chit Limu Moui cung cp mt tp hp cc hp cht l tng thch hp cho cc sn phm x l tc v m phm ca tt c cc loi. i vi bt k ngi no b rng tc do iu tr ha tr, cc dch chit Fucoidan c th l rt c ch. Chng c th c s dng c bn trong ln bn ngoi, di dng thuc p gel v vin p. Hn na, thnh phn Lecithin thin nhin ca Limu Moui c th gip gim mnh s lng ng cht bo di da. Limu Moui cha mt cht vi hm lng cao c gi l cht nhy. Cht nhy l mt hp cht ging keo cung cp mng bo v mm mi v gi m. N c th gip ngn chn s kh chu da v c th gp phn gi nc gi da linh ng, mm. Thc cht, cht nhy ny c th: Ngn chn s kh da, tng cng vic hp th cc phn t nc trong da, lm da chc hn v n hi hn, thc y vic ti to da, tc v mng. (TLTK:http://www.sieuthiyensao.com/xem/fucoidan-than-thien-voi-da-tu-trong-rangoai-193/)

8. Tng cng chc nng gan. Nh gan l mt trong nhng c quan quan trng nht trong c th (chu trch nhim lc cc c t v to ra protein). Vim gan C l mt nguyn nhn ph bin ca bnh x gan. X gan xy ra khi cc m khe mnh ca gan c thay th bng m so, lm gin on chc nng gan. Vi cc vt so, gan khng cn c cc m khe mnh hot ng ng. Cc nghin cu ch ra rng dng Fucoidan c th gip lm gim lng m x trong gan, v cng c th ngn nga x gan xy ra. Fucoidan c kh nng lm gim dung lng cho cc vi rt vim gan C t ti to gan. Nhiu nh khoa hc ang tr nn quan tm nhiu hn v cc ng dng tim nng ca Fucoidan trong iu kin gan mn tnh khc. (TLTK: http://translate.googleusercontent.com/translate_c?depth=1&hl=vi&prev=/search%3

III.

Fq%3DFucoidan%26start%3D20%26sa%3DN%26biw%3D1366%26bih%3D642&r url=translate.google.com.vn&sl=en&u=http://www.Fucoidanextract.com/Fucoidanseaweed&usg=ALkJrhizX8pkcxB6BstjjVSjwoxPp2DPuw) C ch chng ung th ca Fucoidan. iu khin Fucoidan c nhiu ngi quan tm chnh l hng lot cc bo co lm sng da trn rt nhiu nghin cu chng minh rng Fucoidan rt c hiu qu trong iu tr ung th. Rt nhiu ngi thc mc rng vy liu Fucoidan c iu tr c bnh ung th hay khng? Cu tr li l c. Vo nm 2011, mt nghin cu v rong nu Vit Nam ca Nht Bn c ng trn Journal of biological macromolecules (s 49/ 2011) khng nh tc dng ca Fucoidan chit xut t loi rong ny c tc dng trong vic gim t bo ung th. Mi t bo sinh vt u tri qua qu trnh lo ha v t cht i sau khi kt thc nhim v ca mnh. C ch ny nm trong gen di truyn ca t bo, khi nhn lnh ny, t bo s t cht, hin tng ny gi l apoptosis. Nh c ch ny, cc t bo c trong c th cht i, t bo mi sinh ra, qu trnh chuyn ha trao i cht c lp i lp li v sc khe c duy tr. Tuy nhin, t bo ung th l mt loi t bo d thng nhng t bo thay i cu trc v chng khng tun theo qui trnh apoptosis na v nu c nh vy, chng s lin tc phn i ra v tng ln rt nhanh. Trong khi phn ln cc loi thuc chng ung th l cc loi tn cng vo t bo ung th, nhng khng ch t bo ung th m c cc t bo bnh thng v cc t bo min dch ang chin u chng ung th cng b xm hi, khin cho c th ngi bnh b nh hng chnh l tc dng ph ca thuc gy nn cho c th ngi bnh Fucoidan c tc dng tc ng trc tip ti t bo ung th v khin chng t hy dit. Fucoidan khng tc ng g ti cc t bo thng nn khng c tc dng ph, vic ny c chng minh v Fucoidan hin ang c s dng ph bin cho cc trng hp iu tr ung th.) Ba kh nng chnh ca rong bin Fucoidan: to ra s t cht theo chu trnh ca t bo trong cc t bo ung th, nng cao kh nng min dch, c ch s hnh thnh v pht trin cc mch mu, khi u mi. (TLTK: http://Fucoidan.com.vn/nd_dlth.aspx?muc=155&mboardname=tinsk) C ch ca Fucoidan hot ng nh sau: Fucoidan cha ung th nh c hp thu vo h thng bch huyt rut, hot ha t bo NK (Natural killer cell: l loi t bo c chc nng tiu dit nhng t bo nhim tc nhn gy bnh ni bo trong c th) s c hot ha, tng kh nng hot ng ca cc loi t bo, kch thch min dch nh tiu dit v c ch s tng trng ca t bo xu. Mi t bo bnh thng u phi tri qua chu trnh t cht, ch c t bo ung th l vt qua c qui lut ny. Fucoidan khi c t bo ung th hp th vo s t thit lp v bt t bo ung th tun theo chu trnh t cht. iu Fucoidan lm l bt nhng t bo ny quay li vi khun kh, t ngn nga s tng trng v ly lan ca cc t bo ung th. Di tc ng ca Fucoidan, t bo ung th b teo nh, yu dn, tch thnh nhiu mnh v b tiu dit. iu ny gip lm gim qu trnh oxy ha, ngn nga s hnh thnh cc mch mu, khi u mi qua ln ln y li cn bnh ung th.

Trong bnh ung th th hu ht tt c cc khi u u cn dinh dng sng, pht trin v sau cc t bo ung th mi di cn sang cc t bo cc b phn khc. Di y l qu trnh pht trin bnh thng ca mt khi u.

1. S pht trin ca khi u

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Hnh trn ch r khi u c nui dng bi mch mu ca cc c quan xung quanh. trong cc t bo ung th s nhanh chng pht trin v to thnh mt khi u ln dn ln vo cc m bnh thng. vi s pht trin ca khi u s chn v gy p lc ln cc dy thn kinh xung quanh, t nh n mnh khin ngi bnh au khng th chu ng ni. c mch mu nui dng th tc pht trin ca khi u cng rt nhanh. Hnh nh m t khi u b c lp hon ton, ngn nga s tn cng ca oxy hot tnh v c ch s hnh thnh mch mu mi ca t bo ung th, nh vy Fucoidan v tnh ct b ngun cung cp dinh dng cho t bo ung th v dn s teo i

2. Fucodian khng cho mao mch mu nui khi u

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Hnh nh cho thy t bo NK c hot ha, kch thch min dch nh tiu dit v c ch s tng trng ca t bo xu.

3. lm gim kc t c khi u
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Thi gian s dng Fucoidan iu tr ung th c hiu qu cn ty thuc vo tng loi ung th, tng tnh trng nghim trng ca mi ngi, ty liu lng s dng, ty c a mi ngi. D c khc nhau nh th no th c ch Fucoidan cng s nh nhau, mc d thi gian khi bnh c khc nhau nhng u c 1 im chung l y

li c ung th hon ton m khng phi chu au n. Bnh ung th rt d b di cng v ti pht, do vy nhng ngi cha khi bnh ung th nh Fucoidan u mun tip tc s dng Fucoidan nhng vi liu lng gim xung. Hin cha c mt thng k chnh xc no v vic Fucoidan gip cha tr c bao nhiu loi ung th. Tuy nhin, con s loi ung th ngi ta mc phi v cha khi nh Fucoidan l trn 20 loi. Trong phi k n ung th phi, ung th d dy, ung th thc qun, ung th i trc trng, ung th gan, ung th tuyn ty, ung th thn. Tip n l: ung th ti mt, ung th v, ung th d con, ung th bung trng, ung th tuyn tin lit, ung th c hng, ung th thanh qun, ung th bng quang, ung th tinh hon IV. Liu php ca Fucoidan. Liu php Fucoidan l mt phng php iu tr thay th hoc song song vi phng php iu tr truyn thng ang c p dng ph bin hin nay. Liu php ny c c im l da trn l lun mi nht khc vi phng php truyn thng t trc n nay, l vic y t bo ung th n vic hy dit t nhin. Mt khc, Fucoidan cn c tc dng gim thiu ti a cc tc dng ph ca thuc chng ung th hay tia x, do rt nhiu bnh nhn ung th s dng Fucoidan cn v tc dng ny. Do liu php ny rt n gin nn c th d dng p dng ng thi trong thi k iu tr bng cc phng php khc. Ngi mc bnh ung th Nht Bn rt a chung liu php ny do tnh d dng v khng c tc dng ph ca n. Fucoidan va lm tng kh nng min dch, va c tc dng khin t bo ung th t hy dit. Liu php Fucoidan thng c s dng cho nhng bnh sau: Cc loi ung th no, d dy, thc qun,i trng, vm hng, khoang ming, hu, thn, ty, bao t (thuc loi u cng), v, t cung/c t cung, phi, li, thn, da, trc trng, tuyn tin lit, ng mt, gan, tuyn gip, bng quang, bung trng, t bo gan, ty sng, cc loi u bch huyt, u bch huyt c tnh, bnh mu trng, bnh mu trng bch huyt cp tnh, bnh mu trng do ty sng mn tnh, cc loi u, xa cm xng. V. Mt s cc nghin cu khoa hc trong v ngoi nc. 1. Nghin cu tc dng h Lipit mu ca Fucoidan khi lng phn t thp tch chit t rong Nu Vit Nam Ti Vit Nam, nhiu cng trnh nghin cu v Fucoidan c trin khai t khong 10 nm nay. Sn phm Fucoidan th c a ra th trng, tuy nhin nghin cu hot tnh khng ri lon chuyn ha lipit mu ca Fucoidan Vit Nam trn ng vt thc nghim ch mi c mt cng trnh c cng b trn Tp ch Y hc Qun s (s 273, 7/2011). Vit Nam, n , Philippines l ba nc c rong Nu phn b a dng nht trn th gii. Trn c s nh hng cho s dng Fucoidan khi lng phn t thp (MW < 100 kDa) t rong Nu Vit Nam lm dc liu h tr iu tr cc chng bnh bnh tim mch, ung th, chng ti tin hnh mt bc nghin cu su cha tng c thc hin trc y: nghin cu lm sng trn bnh nhn (BN) tnh nguyn nhm mc tiu xc nh tc dng h lipit mu ca Fucoidan tch chit t rong Nu Sargassum polycystum Vit Nam. i tng nghin cu: Nhng ngi c ri lon lipit mu, tc l c mt trong nhng kt qu xt nghim sau y: cholesterol ton phn (TC) > 200 mg%, low-density lipoprtein cholesterol (LDLC) > 130 mg%, triglycerid (TG) > 200 mg%. l nhng BN ni tr v ngoi tr

tnh nguyn tham gia nghin cu theo chp thun trong nghin cu ca Hi ng o c trong nghin cu y sinh. Th nghim c theo di ti Bnh vin 87 (Qun chng Hi qun). - Tiu chun loi tr: c bin chng tim mch (tai bin mch mu no, thiu mu c tim, nhi mu c tim), suy thn, i tho ng khng n nh, tng huyt p ang dng thuc li tiu, nhm c ch bta, thuc ung h ng huyt nhm Metformin. - Tiu ch ngng iu tr: trong qu trnh iu tr nu khng kim tra xt nghim ng thi gian quy nh, hoc c nhng biu hin lm sng khng th dung np thuc nh tc dng ph tr nn trm trng, hoc xt nghim thy transaminase huyt thanh (SGOT, SGPT) tng trn 3 ln gii hn trn c xc nh qua 2 ln th lin tip cch nhau 1 tun th c ngng th nghim v coi nh iu tr tht bi. Kt qu: ch s lipit mu ca cc BN nam nhm nghin cu bao gm TC, LDL-C, TG gim mnh, tng ng l 19,62%, 21,48% v 29,98%. i vi BN l n, ung LMW-F liu 1 g/ngy lin tc trong 4 tun, so snh trc sau cho thy cng ging nh BN nam, HDL-C khng c bin i c ngha thng k (mc d lch hn 14%), ph hp vi kt qu nghin cu trn ng vt thc nghim 2 , tuy nhin cc ch s TC, LDL-C v TG ca BN n nhm nghin cu h mnh, tng ng l 21,34%, 24,32% v 21,1%. (TLTK: http://www.Fucoidan.com.vn/nd_dlth.aspx?muc=370&mboardname=tinvn) 2. Nghin cu v rong Nu bin Vit Nam: ngun dc liu cho dc phm tr ung th. Phn vin vt liu Nha Trang thuc Vin Khoa hc v Cng ngh Vit Nam chit sut thnh cng Fucoidan t rong Nu. Phn vin cng tin hnh nghin cu mt s hot tnh sinh hc ca Fucoidan c trong cc loi rong Nu ny. Kt qu nghin cu trong phng th nghim ca Vit Nam (phi hp vi Hn Quc) cho thy Fucoidan c kt qu tt trong vic c ch, git t bo ung th gan, ung th mng tim v ung th v ngi. Fucoidan cn c tnh cht khng khun. ng Bi Minh L, Phn vin trng Phn vin Vt liu Nha Trang cho bit, trong rong Nu cn c nhiu hp cht khc c gi tr kinh t cao nh laminaran, mannitol, gibberellin, cytokinin, auxin v nhiu loi vitamin. y l mt trong nhng kt qu nghin cu ca ti Nghin cu cng ngh v thit b sn xut Fucoidan quy m pilt t mt s loi rong Nu Vit Nam. Vi kinh ph 500 triu ng, ti c thc hin t nm 2004. D kin t nay n nm 2007, ngoi vic tip tc th nghim hot tnh ca hp cht ny, phn vin s tin hnh bo ch dc liu. Hin ti, Phn vin cng xy dng xong quy trnh cng ngh v ch to thit b chit sut, phn lp cht ny t mt s loi rong Nu c Vit Nam. Vit Nam c hn 120 loi rong Nu vi sn lng c tnh trn 10.000 tn kh/nm. Ngi Vit Nam thng thu hoch nhng loi rong ny lm phn bn. (TLTK: http://ibiopharm.com.vn/rong-nau-bien-vnnguon-duoc-lieu-cho-duoc-phamtri-ung-thu/) 3. Nghin cu mi nht ca Nht Bn v chit sut Fucoidan t rong Nu Vit Nam.

Trong nghin cu ny, kim tra nh hng ca Fucoidan th c chit xut t Sargassum sp (MTA) v fucus vesiculosus (SIG) trn cc t bo ung th phi Lewis (LCC) v cc t bo khi u hc t da c tnh B16 (MC). Trong vitro, cc nghin cu c thc hin bng cch s dng phn tch kh nng tn ti ca t bo v cho thy Fucoidan SIG v MTA lm gim ng k s lng ca cc t bo LCC v MC pht trin liu p ng. S nhum cc cht ha hc cho thy c nhng s thay i hnh thi ca cc t bo u hc t da B16 sau khi tip xc vi Fucoidan. Nhng thay i quan st c th hin Fucoidan th gy ra qu trnh apoptosis. Chut c C57BL/6JJCL b tim mng bng hng ngy, hn 4 ngy vi mt trong hai loi Fucoidan SIG hoc MTA (liu 50 mg / kg trng lng c th). Mc hot ha cc t bo dit t nhin (NK) c tng cng bi Fucoidan th mt cch ph thuc vo liu dng theo s hin th bi cht ng v phng x 51Cr c nh du ln t bo ch lympho chut YAC-1 (dng t bo ung th hch lympho T chut nhy cm vi cc t bo NK)gii phng ra. Nghin cu ny cung cp s th hin r rng Fucoidan th tc ng hiu ng hot tnh sinh hc vo m hnh t bo ung th phi v da trong ng nghim v gy ra s tng cng kch hot cc t bo min dch dit t nhin (NK) trn c th chut th nghim. Fucoidans c th c chit xut v tinh ch t rong bin thng qua qu trnh nhiu bc khc nhau lin quan n vt l, ha hc v / hoc x l enzym v cc bc phn on v tinh ch khc nhau 8 . Mc d cc Fucoidan c chit xut v lm bin i khc nhau, u c bo co pht huy hot tnh sinh hc, Fucoidan th c tm thy pht huy tc dng kh nng min dch ng vt mang khi u, dn n hiu qu chng khi u 9 . Fucoidan th (hoc c cha fucose-sulfate polysaccharides) c th c ly thng qua axit long hoc dung dch nc chit xut bng cch s dng cc bc x l nh hn v t gy bin i cu trc ti thiu do duy tr cc c tnh t nhin ca Fucoidan. Vi kin thc tt nht ca chng ti, cc tc ng ca Fucoidan th trn cc t bo ung th phi v da v cc hot ng phn ng min dch hin vn cha c xc nh. V vy chng ti kim tra tc ng ca Fucoidan th c chit xut t Sargassum sp. V fucus vesiculosus trn s gia tng ca cc t bo khi u ung th phi Lewis v ung th hc t da c tnh B16 v nh gi nh hng ca n i vi hot ng p ng min dch. (TLTK: http://ibiopharm.com.vn/nghien-cuu-moi-nhat-cua-nhat-ban-ve-rong-nauviet-nam/) VI. Mt vi biu hin khi ung Fucoidan. i vi mt vi ngi, khi s dng Fucoidan s c cc biu hin i ngoi phn mm trong vng ba n bn ngy. l bi v Fucoidan l mt si rau nn c cc chc nng lm sch rut, mt vi ngy sau h s tr li bnh thng. i ngoi phn mm khng c ngha l b mc bnh tiu chy. Mt triu chng l to bn s khng cn v c ng ca rut s c ci thin. Ni chung, Fucoidan s em li nhng li ch lu di sau cho cc bnh nhn: Tnh trng c th c ci thin v nc bt ngt hn. Ly li c v gic v nng cao chc nng ca h tiu ho. Lm gim bt cc phn ng ph ca ho hc tr liu v gim bt cn au do bnh ung th gy ra.

Tng kh nng min dch Cho thy phn ng lm sng ca vic gim tc nhn gy u bu hoc gim cc t bo ung th. Mt ngi kho mnh khi ung Fucoidan, h c th nhn thy s thay i v th cht, thy c s khc bit ring. c bit vi ph n, Fucoidan gip h c nc da p hn v nh hng tch cc n chu k kinh nguyt. -

PH LC TRANG TI LIU THAM KHO Tp ch khoa hc v cng ngh - tp 45, s 1, 2007. Tp ch khoa hc, i hc Hu- tp 74A, s 5, 2012. http://www.thuocFucoidan.com/cau-chuyen-Fucoidan/su-that-ve-thuoc-tri-ung-thuFucoidan.html http://Fucoidan.com.vn/nd_dlth.aspx?muc=273&mboardname=tvsk http://translate.google.com.vn/translate?hl=vi&sl=en&u=http://www.Fucoidanextract.com/F ucoidanoverview&prev=/search%3Fq%3DFucoidan%26start%3D20%26sa%3DN%26biw% 3D1366%26bih%3D642 http://translate.googleusercontent.com/translate_c?depth=1&hl=vi&prev=/search%3Fq%3D Fucoidan%26start%3D20%26sa%3DN%26biw%3D1366%26bih%3D642&rurl=translate.go ogle.com.vn&sl=en&u=http://www.Fucoidanextract.com/Fucoidanseaweed&usg=ALkJrhizX8pkcxB6BstjjVSjwoxPp2DPuw http://en.wikipedia.org/wiki/Fucoidan http://www.zenmony.com/mechanisms-of-Fucoidans-anticancer-action-1-2-3-of-5-a29/ http://Fucoidan.com.vn/nd_dlth.aspx?muc=155&mboardname=tinsk http://www.sieuthiyensao.com/tin-tuc-yen-sao/cong-dung-cua-Fucoidan/ http://www.Fucoidan.com.vn/nd_dlth.aspx?muc=370&mboardname=tinvn http://yduocvn.com/?x/=newsdetail&n=4491&/c/=98&/g/=24&/9/6/2010/hoi-chung-viemphuc-mac.html http://ibiopharm.com.vn/rong-nau-bien-vnnguon-duoc-lieu-cho-duoc-pham-tri-ung-thu/ http://ibiopharm.com.vn/nghien-cuu-moi-nhat-cua-nhat-ban-ve-rong-nau-viet-nam/ http://www.vjol.in fo/index.php/jst/article/viewFile/4922/4651 http://vietbao.vn/Khoa-hoc/Chiet-suat-thanh-cong-Fucoidan-tu-rong-nau/20471219/189/ http://taoxoan.vn/taomattroi/Fucoidan-chua-ung-thu/ http://www.secviet.cz/anhqc/star/sontri.htm http://vidatoxcuba.vn/vidatox-tieu-diet-te-bao-ung-thu-nhu-the-nao