Bi 6:

TNG HP (E)-10-hexadecenal t acrolein

Retrosynthesis
O OAc O O O O O O O O Br Br OH

TNG HP (E)-10-hexadecenal t acrolein

synthesis
1. HBr Br 2.etylenglycol, CH2Cl2

O O

O
1. Mg,THF/Li2CuCl4 Br 2. Br(CH2)6Br

1. Mg, THF 2. acrolein, THF

O O
OAc BuMgBr/CuI,THF

Ac2O,Et3N DMAP,CH2Cl2 OH

O O

(chuyn v allyl)

O O

HCl aq/Me2CO O