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GII THIU CHUNG V TI U HA
NG DNG CA TI U HA TRONG CNTP
THIT K TH NGHIM V X L S LIU: TNG QUAN
QUI TRNH TI U HA
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GII THIU CHUNG V TI U HA
NG DNG CA TI U HA TRONG CNTP
THIT K TH NGHIM V X L S LIU
QUI TRNH TI U HA
XT MT QU TRNH
SN XUT
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Factors
Independent variables
Process variables
Response
Dependent variable
Optimization can be defined as the process of finding the
conditions that give the optimum (maximum or minimum)
value of a function of certain decision variables subject to
restrictions or constraints that are imposed.
The conditions (values of the processing variables) that
produce the desired optimum value are called optimum
conditions
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LOCAL OPTIMUM vs.GLOBAL OPTIMUM
LOCAL OPTIMUM vs.GLOBAL OPTIMUM
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Hy xc nh optimum condition trong cc trng hp sau:
(Lm vic theo nhm)
Qutrnhkhai thcnc ma
Qutrnhlmsch tp cht
Qutrnhchin
Qutrnhlnmen
Qutrnhvi bao
Max ? Min ?
GII THIU CHUNG V TI U HA
NG DNG CA TI U HA TRONG CNTP
THIT K TH NGHIM V X L S LIU
QUI TRNH TI U HA
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1. Determiningtheconditionsthat optimizetheprocess.
2. Reducevariationsinquality.
3. Selection of Operating Conditions to Achieve
Specificationsor Customer Requirements
4.
1. Determiningtheconditionsthatoptimizetheprocess.
2. Reducevariationsinquality.
3. Selection of Operating Conditions to Achieve
Specificationsor Customer Requirements
4. ..
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1. Determiningtheconditionsthat optimizetheprocess.
2. Reducevariationsinquality.
3. Selection of Operating Conditions to Achieve
Specificationsor Customer Requirements
4.
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1. Determiningtheconditionsthat optimizetheprocess.
2. Reducevariationsinquality.
3. Selection of Operating Conditions to Achieve
SpecificationsorCustomerRequirements
4.
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1. Determiningtheconditionsthat optimizetheprocess.
2. Reducevariationsinquality.
3. Selection of Operating Conditions to Achieve
Specificationsor Customer Requirements
4.
Sinh vin a ra cc tnh hung
cn ti u ha khc
(Lm vic theo nhm)
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GII THIU CHUNG V TI U HA
NG DNG CA TI U HA TRONG CNTP
THIT K TH NGHIM V X L S LIU
QUI TRNH TI U HA
THIT K TH NGHIM
TH NGHIM MT YU T
TH NGHIM KT HP NHIU YU T
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TH NGHIM MT YU T
n gin nht, bin u vo (x) thng l bin phn nhm
(Categorical variable)
Ch xemxt nh hng ca mt yu t u vo xlnccyu
t u ray, ccyu t xcnli c c nh
B quatng tc(Nointeraction)
Effect: xcthc s nh hng ngha lnyhaykhng?
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TH NGHIM MT YU T (tip theo)
Th nghim hontonngu nhin(Completely Randomized
Design CRD)
Th nghim khi ngu nhiny (RandomizedComplete
BlockDesign RCBD) Lmvic nhm
Th nghim vung La tinh (Latin Square) Lm vic
nhm
TH NGHIM MT YU T HON TON NGU NHIN (CRD)
VD: Kho st nh hng ca t l
protein b sung (x) ln chc
ca ch c (y).
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TH NGHIM MT YU T HON TON NGU NHIN (CRD)
T l protein/ch c
(%, w/w)
Ln 1 Ln 2 Ln 3 Ln 4
10 181 179 182 183
14 194 197 201 195
18 204 208 205 206
22 213 214 210 209
26 216 214 212 215
TH NGHIM KT HP NHIU YU T
nh ginh hng ng thi ca nhiu yu t
Cxt n tng tc
Cnhiu u im hn OFAT
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TH NGHIM KT HP NHIU YU T
(Sinh vin v xem li l thuyt QHTN)
Qui hoch thc nghimcp I
Qui hoch thc nghimcp II
y
opt
y
opt
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First-order model
(To get close to the peak)
Second-order model
(To locate the peak)
Du hiu no cho thy first-order
khng cn ph hp, cn s dng
second-order?
(Lm vic theo nhm)
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One Factor At a time DOE
(A larger region of the factor space)
OFAT vs. DOE
OFAT vs. DOE: INTERACTION
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Nghincu nh hng ca nng ng (A,%) vnhit
sy (B,
0
C) n mm ca sn phm (N).
0% 25%
150.6 173.8
50
0
C 128.9 161.3
137.2 155.6
225.1 320.4
60
0
C 210.6 301.9
218.5 296.4
Kt qu phntchthng kchothy yu t AvBctng tc. Hy
phntchtng tc?
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X L S LIU
PHN TCH PHNG SAI (ANOVA)
PHN TCH HI QUI (REGRESSION)
TH NGHIM MT YU T
(CRD)
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TH NGHIM MT YU T HON TON NGU NHIN (CRD)
T l protein/ch c
(%, w/w)
Ln 1 Ln 2 Ln 3 Ln 4 TB
10 181 179 182 183 181.3
14 194 197 201 195 196.8
18 204 208 205 206 205.8
22 213 214 210 209 211.5
26 216 214 212 215 214.3
PHN TCH PHNG SAI
(ANOVA)
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Between-group variation: bin thin (khc bit) gia cc
nhm c trng cho nguyn nhn do nhn t th nghim
(ph thuc bn cht ca factor).
Within-groupvariation: bin thintrongni b nhm c
trng chonguynnhndongu nhin.
02 loi bin thin (variation)
Within-group
variation (SS
W
)
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Within-group variation (Sum of Squares -SS
W
)
SS
W10
=(181-181.3)
2
+(179-181.3)
2
++(183-183.3)
2
=8.75
SS
W14
=28.75
SS
W18
=8.75
SS
W22
=17
SS
W26
=8.75
SS
W
=SS
W10
+SS
W14
+SS
W18
+SS
W22
+SS
W26
=72
MS
W
=72/(20 5)=4.8
Between-group variation (SS
B
)
Overall mean=(181+179+182+.+212+215)/20=201.9
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Between-group
variation (SS
B
)
Overall mean
201.9
SS
B10
=4*(181.3 201.9)
2
=1705.69
SS
B14
=106.09
SS
B18
=59.29
SS
B22
=368.64
SS
B26
=610.09
SS
B
=SS
B10
+SS
B14
+SS
B18
+SS
B22
+SS
B26
=2849.8
MS
B
=2849.8/(5 1)=712.45
Between-group variation (SS
B
)
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43 . 148
8 . 4
45 . 712

TN
F
056 . 3
crit
F
KT LUN
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PHN TCH HI QUI
JMP
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SPSS
Ngi tatin hnhkho st nh hng ca 04loi mi trng nui cy khc
nhauhiu sut thunhn enzymengoi bo(IU/mgprotein) t mt loi vi sinh
vt.
Mi trng 1 Mi trng 2 Mi trng 3 Mi trng 4
99 61 42 169
88 112 97 137
76 30 81 169
38 89 95 85
94 63 92 154
C bng chng kt lun loi mi trng nui cy nh hng cngha
thng klnhiu sut thunhn enzymehaykhng?Bit F
crit
=3,24.
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Ngi ta tin hnh kho st nh hng ca 04 loi bao b khc nhau ln t l
gim khi lng (%,w/w) ca mt loi tri cyti sau01thngbo qun lnh.
Bao b 1 Bao b 2 Bao b 3 Bao b 4
4,56 3,65 5,02 4,57
4,36 4,00 4,76 4,56
4,32 3,75 4,87 4,67
4,63 3,87 4,99 4,87
4,54 4,08 4,76 4,69
4,53 3,55 4,53 4,32
C bng chng kt lun loi baob nh hng cngha thng klnt
l gimkhi lng haykhng?Bit F
crit
=3,098.