USDA United States Department of Agricutture ‘Animal and Plant Health Inspection Service 278305 inp Inspection Report LOVELAGE RESPIRATORY RESEARCH INSTITUTE Customer ID: 1072 Cerificate: 85-R-0003 Site: 001 2425 RIDGECREST SE Type: ROUTINE INSPECTION ALBUQUERQUE, NM 87108. Daten, May. 23:2008 3.75 @ HOUSING FACILITIES, GENERAL, .<> (On March 27, 2008, a female Cynomologus monkey Was found dead with her head caught between tha wall and the perch of her enclosure. On May 11, 2008. an infant Gynamologus was noted to be outside ofits primary enclosure by security personnel. & hole in the enclosure mesh had allawed the animal to escape fram its enclosure but the animal was in 3 secondary containment area s0 could be salely captured and returned oa secure enclosure. Housing facilities for nonhuman primates must be designed, constructed, and kept in good repair so they protect the ‘animals from injury end contain the animals securely To be corrected immediately. Inspection was pertarmed on May 28-29, 2008 to follaw-up an noncompliances cited on the previous April 16, 2008 inspection. Accompanied by the Staif Veterinarian, Director App. Life Sci.!Senior Scientist, Associate Animal Resources Director, |AGUC Chair, and |AGUG Administrator. Exit interview performed on site on May 29, 2008 with the institutional Oficial, ACUG Chair, |ACUG Administrator Associate Animal Resources Director, Director App, Life Sol,/Senior Scientist, Director of Facities, Director of Quality, Director South Operations, and Assistant Director to PMI. Exit interview performed by telephone with the Animal Resources Birector on June 12, 2006. repared By: TRACY ATHOMPSON, DVM. USDA, APHIS, Animal Care Date: Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 Jun-19-2008 Received By: Date: Title: Jun-12-2008USDA United States Department of Agricutture ‘Animal and Plant Health Inspection Service rosoa223e080606 inept Inspection Report LOVELACE RESPIRATORY RESEARCH Customer 10: 1072 Certficate: 85-A-0008 2425 RIDGECREST SE Site: 001 LOVELACE RESPIRATORY RESEARCH ‘Type: ROUTINE INSPECTION ALBUQUERQUE, NM 87108 Date: Apr-15-2003 375 ) 1) i) HOUSING FACILITIES, GENERAL. <> ‘A restraint device used for nonhuman primates was found to have a sharp point due to a crack in the plexiglass insert that could come in diract contact with an animal's neck when placed in the chair ‘Any surfaces that come in contact with nonhuman primates must be free of sharp points thet might injure the animals. Ta be corrected by 4/1 6/09. 3.75 HOUSING FACILITIES, GENERAL. <> Three rooms in the facility that house nonhuman primates de not drain properly and the waste water trom cleaning the cages and the room pools in the comidor outside of the reams, This pooling of water and and waste material poses a risk for odor and disease. repared By: TRACY ATHOMPSON, VIMO, USDA, APHIS, Animal Care Date: Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 ‘Apr-18-2009 Received By: Date: Title: ‘Apr-16-2003USDA United States Department of Agriculture Animal and Plant Hoalth Inspection Service voseazese200606 rand Inspection Report Housing facilities for nonhuman primates must be constructed, installed, and maintained such that water is rapidly eliminated and to minimize odors and disease hazards. Ta be corrected by 4/30/09. ‘Accompanied on inspection by the |ACUC Chair, the Animal Resources Director, the Compliance Monitor, the Animal Resources Husbandry Supemisor, the IACUS Coordinator, the Director of South Operation: Scientist, and the Clinical Velerinarian/Associale Scientist, the Associate Research repared By: TRACY ATHOMPSON, VIMO, USDA, APHIS, Animal Care Date: Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 ‘Apr-15-2009 Received By: Date: Title: ‘Apr-16-2003USDA United States Department of Agricutture ‘Animal and Plant Health Inspection Service assTT inspie Inspection Report LOVELACE RESPIRATORY RESEARCH Customer 10: 1072 Certficate: 85-A-0008 2425 RIDGECREST SE Site: 001 LOVELACE RESPIRATORY RESEARCH ‘Type: ROUTINE INSPECTION ALBUQUERQUE, NM 87108 Date: Apr-16-2008 234 © ©) REPEAT INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC), <<2.31 (c){3) Repeat NCI-IACUG Functions. With respect to activities involving animals, the [ACUC. as an agent of the research facility, shall: Prepare reports ofits evaluations conducted as requiced by paragraphs (c)(1) and (2) of this section, and submit the reports to the institutional Giicial ofthe research facility; If program or facility deficiencies are notad, the reports must contain a reasonable and spectlic plan and schedule with dates for correcting ‘each deliciency. Any failure to adnera te the pian and sched that results in a significant deficiency remaining Uncorrected shall be reportedin writing within 15 business days by the ACU, through the Institutional Otficial, 10 APHIS and any Federal agency funding that activity>> The IACUC report prepared on March 14, 2006 for the semiannual facility evaluation done in October 2007 did nat contain a speciic plan or dates for correcting deficiencies identified by the IACUC members performing the evaluation. This is a repeat noncompliance previousiy cited during the inspection performed on April 10, 2007 and which had a correction date of April 18, 2007 231 @® REPEAT INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC). <<2.31 (d)(1)..the IAGUG shall determine that the proposed activities or significant changes in ongoing activities: meet the following requirements Repeat NCI-(i) The principal investigator has considered alternalives to procedures that may cause more than momentary oF slight pain or distress to the animals, and has provided a writien narrative deseription of the methods and sources, ¢. g., the Animal Weltare Information Center, used ta determine that altematives were not available;>> ‘A-change to an appraved animal use activity (08-098) was submitted to the |ACUC: without any consideration by the principal investigatar for alternatives far a procedure (intracardiac venipuncture) that could cause more than repared By: TRACY ATHOMPSON, VIMO, USDA, APHIS, Animal Care Date Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 Apr-21-2008 Received By: Date Title ‘Apr-23-2008USDA United States Department of Agriculture mous Animal and Plant Health Inspection Service areart noni Inspection Report momentary pain or distress. This is a repeat noncompliance previousty cited during the inspections performed April 13, 2006, April 7, 2005, and May 12, 2003 and which had a correction date of May 12, 2003. 231 ©) 1) Gi) DIRECT NCI INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC). <> ‘An incorrect anesthetic regimen was used by a technician tor restraint of a rabbit which resulted in an injury to this technician. The technician was unaware that the writen drug regimen was incorree! for this species, The facili is maintaining a pool of technical personnel from which the prineipal investigators receive assistance: in animal activities. All personnel in this pool are listed cn proposed animal activities subrmitted to the LACUS for ‘approval regardless of their qualifications and personnel have been assigned to do work for which they are nat adequately trained nor have experience ta perform. Evidenoe of this was found during review of committee minutes and in discussion with committee members. The IAGUG shall determine that all personne! will be appropsiately qualified and trained in procedures being conducted on the spacies maintained or studied. No personnel should handle any animal or engage in ary procedures for which they are nat appropriately qualified To be corrected by immediately. 2.32 (a) DIRECT NCI PERSONNEL QUALIFICATIONS. <> ‘An incorrect anesthetic regimen was used by a technician for restraint of a rabbit which resulted in an injury to this technician. The technician was not aware thal the dosages were incorrect on the instructions for the regimen for this species. repared By: TRACY ATHOMPSON, VIMO, USDA, APHIS, Animal Care Date Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 Apr-21-2008 Received By: Date Title ‘Apr-23-2008USDA United States Department of Agriculture Animal and Plant Health Inspection Service anert insp_id Inspection Report The facily is maintaining a pool of technical personnel from which the principal investigators receive assistance in animal activities. All personnel in this pool ae listed on proposed animal activities submitted to the IACUC for approval regardless of their qualifications and personne! have been assigned to do work for which they are nat adequately Irained nor have experience te perform. Evidence of this was found during review of committee minutes ‘and in discussion with committee members. The facilily shall ensure that all personne! involved in animal care and use are qualified to periorm their duties, including provision ot training and instruction to personnel as needad. No personnel should handle any animal or engage in any procedures for which they are net appropriately qualified. Ta be coected by immediately, 2.33 b) 5) DIRECT NCI ATTENDING VETERINARIAN AND ADEQUATE VETERINARY CARE. <<(b)(5) Direct NCI-- Adequate pre-procedural and post-procedural care in accordance with current established veterinary medical and nursing procedures.>> ‘Several nanhuman primates were discovered by the Husbandry Services Manager to be recovering from anesthesia, in recumbency, but with food and water in their primary enclosures and no personnel in observance, The personnel who were supposed to be observing these animals had not follawed veterinary instruction to remain in observance of the animals until they were fully recovered from anesthesia and prior ta providing food and water. These animals were at risk for aspirating food material while they were semiconsciaus. ‘Adequate pre-and post-procedural care shall be provided as part of the facility's program of adequate veterinary To be corrected immediately. ‘Accompanied on inspection, pertarmed April 16, 2008, by the Staff Veterinarian, Husbandry Services Manager, Associate Animal Resources Director, |ACUG Chair, and IAGUC Administrator. Exit interview conducted on April 17, 2008 with the Institutional Official, Husbandry Services Manager, Associate Animal Resources Director, |ACUC Chair, |ACUC Administrator, two Principal Investigators, Director of South Operations, andiwo Supervisors, repared By: TRACY ATHOMPSON, VIMO, USDA, APHIS, Animal Care Date Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 Apr-21-2008 Received By: Date Title ‘Apr-23-2008USDA United States Department of Agriculture Animal and Plant Health Inspection Service areart noni Inspection Report 2.33 (b) (4) DIRECT NCI ATTENDING VETERINARIAN AND ADEQUATE VETERINARY CARE. <> ‘An incorrect anesthetic regimen, which was net roviewed or approved by a veterinarian nor approved by the |ACUC, was used for restraint of rabbits during intracardiac venipuncture (Protocol 06-096). The use of this unapproved regimen did not produce adequate anesthetic levels to facilitate the procedure, resulting in repeated anesthetic injections to atleast one animal and injury to the technician due to inadequate restraint. The facility shall establish and maintain programs of adequate veterinary care that include guidance to all personnel involved in the care and use of animals regarding handing, immobilization, anesthesia, analgesia, tranquilization, and euthanasia. To be corrected immediately. repared By: TRACY ATHOMPSON, VIMO. USDA, APHIS, Animal Care Date: Title: _ VETERINARY MEDICAL OFFICER Inspector 5044 Apr-21-2008 Received By: Date: Title ‘Apr-25-2008 ape $01 4