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A-level
Detailed structure
NH2
N
H
phosphate
O-
base
-O
deoxyribose sugar
phosphate
group
P
O
C
N
C
C
C
N
N
C
nitrogenous base
CH2 O
H
H
H
H
OH OH
sugar
In all DNA molecules, the pentose sugar and the phosphate group remain the same and are
sometimes called the sugar-phosphate backbone. It is the nitrogenous base that is the different
component in different nucleotides.
Adenine (A)
Guanine (G)
Cytosine (C)
Thymine (T)
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}
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nucleotide bases
Topic Builders
A
C
phosphate
backbone
G
A
T
G
sugar-phosphate
backbone
T
G
A
C
Each species is unique, or genetically different, and will have different amounts of base
pairing.
The exact order, or sequence, of the different bases along the polynucleotide chain/strand
varies, and this forms the genetic information stored by the DNA. The two strands are
twisted and form a double helix.
DNA is a large stable molecule, highly coiled and condensed, which remains constant in
the cell.
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Messenger RNA (mRNA) is made in the nucleus and moves into the cytoplasm. The
length and base sequence varies. It is involved in protein synthesis.
Transfer RNA (tRNA) is single stranded and clover leaf shaped. Many different types of
tRNA are found in the cytoplasm. It is also involved in protein synthesis. It has three bases,
called the anticodon, which codes for an amino acid attached to one end.
amino acid
attached here
OH
5 end
H-bonds
D
G
D G A
C U C G
(
$
(
(
"
6
6
U
G G A G A G C G
C
C
A
G
A
C
U
G
3 end
A
C
C
"
$
(
$
6
6
"
"
C U
G A C A C
G
C U G U G
C
C
T s
U
G
G
G A
modied
G
nucleotides
U
C
s
A
H
anticodon loop
A A
Anticodon
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Ribosomal RNA (rRNA) is made in the nucleolus and is part of the ribosome in
cytoplasm.
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Task 1
Complete the table below to summarise the differences between DNA and RNA.
Feature
DNA
RNA
Number of polynucleotide
chains
Topic Builders
Nucleotide bases
Pentose sugar
Type of nucleic acid present
Location in cell
Task 2
Complete the missing complementary bases for the following double helix.
3
Questions
1
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Taking it Further
Make more detailed notes about the structure and functions of nucleic acids. You may find it
useful to draw the structure of a nucleotide and to list the differences between DNA and RNA in
a table.
The questions below can help you to structure and organise your notes. Use your course text
book to add further information.
What is DNA and what is its role?
List three differences between DNA and RNA.
What is the base pairing rule?
What two components make the backbone of the strand, and what links the two strands of
DNA?
If a sample of DNA had 19% of cytosine nucleotide, what percentage of its nucleotides will
be adenine? How can this be worked out?
Find out about the roles of different RNA nucleotides in protein synthesis.
What does anti-parallel mean?
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