? Ti sao tht g li khc tht b ?

Ti sao sinh vt ny li n sinh vt khc?

Bi 5

NI DUNG:
I. CU TRC CA PRTIN
1. Cu trc bc 1.
2 . Cu trc bc 2
3. Cu trc bc 3 v 4
II. CHC NNG PRTIN

I. CU TRC Prtin
1. Axit amin n phn ca prtin

Axit amin gm nhng nhm no?

Axit amin gm 1 nhm amin, gc

cacbua hidr (gc R) & 1 nhm
cacbxyl

Cc axit amin khc nhau

? nhm no?
- Cc axit amin khc nhau gc R
- Trong t nhin, c khong hn 20
loi axit amin khc nhau

- Cc axit amin khc nhau gc R

- Trong t nhin, c khong hn 20
loi axit amin khc nhau

Prtin tn ti trong khng gian nh

th no?
?

Glixin

Xrin

Alanin

Tirxin

Xistrin

CC BC CU TRC CA PROTEIN

protein c nhng bc cu trc no?

k tn

Cu
trc
bc 1

Cu trc bc 2

Cu trc bc 3

Cu trc bc 4

? Cn c
vo u ta
c th phn
bit c
cc cp
cu trc
prtin?

Bc 1
Cc axit
amin lk nhau
to chui
plipeptit
-

Bc 2
-L

cu hnh
mch
plipeptit
trong khng
gian

Bc 3

Bc 4

hnh
mch
plipeptit
trong khng
gian 3 chiu

- 2 hay nhiu
chui
plipeptit
phi hp
nhau to
phc h
prtin

-L

Lin kt peptid l g?

Lin kt peptit l lin kt gia

nhm cacbxyl ca axit amin trc
vi nhm amin ca axit amin sau &
gii phng 1 phn t nc

Lin kt Peptit

Ti sao Prtin va c
trng va a dng?

Prtin c cu trc a phn nn ch

hn 20 loi axit amin cho 1014 lai
prtin khc nhau v s lng, thnh
phn, trt t sp xp v cu trc khng
gian

 Hin tng bin tnh Prtin:

@ Tc nhn:
- Nhit
- PH

@ Kt qu:
- Ph hy cu trc khng gian ca Prtin
- Gy bin i chc nng ca Prtin
?

Khi nhit c th cao trn 42oC th bnh nhn s

cht.V sao ?

II. Chc nng prtin

- Cu to
VD: Clagen tham gia cu to m lin kt
- D tr cc axit amin
VD: Albumin
- Vn chuyn cc cht ( prtin vn chuyn)
VD: Hemoglobin vn chuyn O2 v CO2

Hnh

- iu ha hot ng c th (Prtin hocmn)

VD: Insulin iu ha ng trong mu

Hnh

Chc nng prtin

- Gip t bo nhn tn hiu ha hc( prtin th th).
VD: Prtin th th mng

Hnh

- Vn ng (prtin co gin)
VD: Prtin cu to ui tinh trng
- Chng bnh tt
VD: Cc khng th
- Xc tc (enzym)
VD: Protaza thy phn prtin

Hnh

Cu trc nn mng t bo

Insulin iu ha ng trong mu

Mu

Knh gluc

Cht nhn insulin

T bo

CNG C
? Th no l lin kt peptit ? Cho VD
?

Cn c vo u ta phn bit cc bc cu trc

prtin? Phn bit cc cu trc

CNG C
?

T nhn, t tm, tc, tht g u c cu to bi

prtin nhng chng khc nhau v c tnh. Ti sao?
(Tho lun 1pht, mi nhm gm 4 hc)
V prtin c th v a dng v s lng, thnh
phn v cu trc

DN D
V nh tr li cc cu sau:
? Ti sao mt s sinh vt sng c trong sui nc
nng c nhit gn 100oC m prtin khng b bin
tnh?
? Ti sao khi un nc lc cua th prtin cua li
ng thnh tng mng?