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HA HC ACID AMIN
nh ngha: Acid amin l nhng cht hu
c trong phn t c hai nhm chc
carboxyl v amin cng gn vi carbon
Trong t nhin c 20 aa thng gp cu
to nn protein
Phn loi:Da vo gc R chia lm 5
nhm: Acid amin c gc R khng phn
cc, R phn cc nhng khng tch in,
R nhn thm, R base, R acid.
Nhm amino
-carbon
Chui bn
ng phn quang hc ca
acid amin
Cc sinh vt ch tng hp v
s dng L- acid amin
Acid amin c gc R
khng phn cc (6 aa)
Tnh k nc
Tt c rt k nc
Gc R l nhn thm
Hp th UV ti 280 nm
Phenylalanin (Phe, F)
Tyrosin (Tyr,Y) -OH c kh nng ion ha (pKa = 10.5)
Tryptophan (Trp, W) 2 vng gm c vng indol
a nc
Tch in dng ti pH sinh l
Histidin (His) nhn imidazol tn ti di dng ion dng,
l acid amin duy nht c kh nng m pH sinh l.
Lysin (Lys) tch in dng ti pH 7.0
Arginin (Arg) - guanidinium ion lun tch in dng, l
acid amin c tnh kim nht
H
H+
+:
pKa = 6.0
Ha hc protein
Phn loi:Theo hnh dng
1.Protein hnh si: t l chiu di/chiu rng
> 10. L cc protein cu trc
2.Protein hnh cu: t l chiu di/ chiu rng
< 10. L cc protein chc nng
Phn loi: Theo cu to
1.Protein thun: Ch do aa cu to ln
2.Protein tp: ngoi aa cn c thnh phn
khc khng phi aa (nhm ngoi)
CU TRC CA PROTEIN
Cc loi lin kt trong phn t protein:
Lin kt peptid
Lin kt disulfur
Lin kt hydro
Lin kt ion (lin kt mui, lin kt tnh
in)
Tng tc k nc
Cu trc lp th hay gp
ca lin kt peptid (ng phn)
Cu hnhTrans;
Hay gp trong t nhin v
thun li v khng gian
Cu hnh Cis ;
Him gp v khng thun
v khng gian
Cc bc cu trc ca protein
Cu trc bc mt ca
protein l do s lng,
loi v trnh t sp xp
cc acid amin trong chui
polypeptid to nn.
Lin kt quyt nh cu
trc bc 1 l lin kt
peptid.
Cc protein khc nhau c
cu trc bc mt khc
nhau
Quai v im quay
Quai:
Thng cha cc gc a nc.
Tm thy trn b mt protein.
Ni xon alpha v gp np beta.
im quay:
Quai c < 5 aa c gi l im quay
Cc im quay beta rt hay gp
Gp np Beta
Cu trc gp np
Beta to thnh t
nhiu chui beta sp
xp cnh nhau.
Cc chui c th song
song hoc i song.
Cu trc tm i song
n nh hn.
Cu trc bc ba
Tt c cc protein hnh
cu c cu trc bc 3.
Cc phn t protein
c cu trc bc 2 b v
gp li to cu trc khng
gian 3 chiu hnh cu.
NHN HEM
PHN T MYOGLOBIN
Myoglobin l protein
c trong t bo c. Cc
lin kt H, lin kt ion,
tng tc k nc v
cu disulfur bnh n
cu trc bc 3
Cu trc bc 4
b e ta c h a in
b e ta c h a in
Ch cc protein c t 2 chui
Polypeptid tr ln mi c
th c cu trc bc bn.
Cc lin kt H, lin kt ion,
tng tc k nc
bnh n cu trc bc bn
a lp h a c h a in
a lp h a c h a in
ir o n - c o n t a in in g
h a e m g ro u p
Phn t Hemoglobin
Vai tr cu trc
Vai tr xc tc: enzym
Vai tr vn chuyn:
Vai tr bo v
Vai tr vn ng
Vai tr iu ha
Cc vai tr khc