1.1 Tc dng h st.

C ch gy st v h st ca NSAID.
- Cht gy st ngoi lai (vi khun, c t,
nm) xm nhp vo c th s kch thch c
th sn xut ra cht gy st ni t. Cht ny
hot ha men Cyclo-oxynase (COX), lm
tng hp PG (E1,E2) t acid arachidonic ca

- PG gy st do lm qu trnh to nhit
(tng rung c, h hp, chuyn ha) v
ha trnh thy nhit (co mch da.)
- Thuc h st do c ch COX lm gim tng
hp PG do lm gim qu trnh gy st nn
c tc dng h st.

1.2 Tc dng gim au.

- c ch tng hp PG E2 nn lm gim tnh
cm th ca cc ngn dy cm gic vi cc
cht gy au ca phn ng gy vim nh
Bradykinin, histamin.
1.3 Tc dng chng vim
- c ch Cyclooxyganase ( COX ), lm gim
tng hp PGE2 v F1 l nhng cht trung gian
ha hc ca phn ng vim.

NSAID theo kh nng c ch COX-1 v COX-1.

Nhm 1 NSAID c ch c COX-1 ln COX 2

( t chn lc ).
Nhm 2 NSAID c ch COX-2 5-50 ln hn

so vi COX-1.
Nhm 3 NSAID c ch COX-2 > 5 ln hn so

vi COX-1.

2.1 Nhm 1.
Tc Dng.

- Chng vim khng steroid.

- au, st mnh.
Ch nh.

- iu tr di ngy vim khp mn, thoi ha kh

- au cp (vim sau chn thng, sng m).
- Vim a khp dng thp thiu nin.

2.1 Nhm 1
Chng ch nh.

- Lot d dy tin trin.

- Ngi b hen hay co tht ph qun, bnh tim m

- Suy gan hay suy thn nng.
Tc dng ph.

- Bun nn, kh tiu, tiu chy.

- Bun ng, trm cm, lo u.
- Suy thn cp.

Mt s thuc thng gp.

- Liu khi u: 200 400 mg; lp li liu ny

mi 4 6 gi nu cn. Khng qu 1200mg/ngy.
-Thp khp: 2400mg/ngy. Duy tr 1200-

1400/ngy.

Mi ln ung 1 vin 500mg, 3 ln/ngy hay

theo s ch nh ca bc s.

Ngi ln: 50 150mg/ngy, chia 2-3 ln/ngy.

2.2 Nhm 2
Tc dng.
- au, h st, chng vim.
Ch nh.
- Vim au xng khp.
- Vim khp dng thp.
- Vim ct sng dnh khp.

2.2 Nhm 2
Chng ch nh.
- B hen suyn, ni m ay.
- Lot d dy t trng.
- Ph n c thai.
Tc dng ph.
- Bun nn, kh tiu, y hi, to bn.
- Suy thn, suy tim.

Mt s thuc thng gp.

- Thoi ha khp: Liu duy nht 200 mg/ngy

hoc 100 mg x 2 ln/ngy.
- Vim khp dng thp: 100-200 mg x 2
ln/ngy.
- Vim ct sng dnh khp: 200 mg/ngy hoc

- Vim khp dng thp, vim ct sng dnh

khp: 2 vin/ln/ngy.
- Khi iu tr lu di, nht l ngi cao tui
hoc ngi c nhiu nguy c c tai bin ph: 1
vin/ln/ngy. Khng c vt qu liu 2

- Cp tnh: 200-400mg/ln x 3-4 ln /ngy

- Mn tnh: Liu thng dng l 8001200mg/ngy, chia liu 2-4ln. Tng liu khng
nn qu 1200mg/ngy.

2.3 Nhm 3
Tc dng.
- au, h st, chng vim.
Ch nh.
- au trong vim khp.
- cc cn au cp.
- au bng kinh k.

2.3 Nhm 3
Chng ch nh.
- B hen, ph hng v mt.
- Lot d dy t trng.
- Suy gan hoc qu mn.
Tc dng ph.
- huyt p.
- Ph ngoi vi.
- Bun nn, tiu chy.

Mt s thuc thng gp.

- Vim xng khp: liu khi u l 12,5mg,

ung mt ln trong ngy.
- Mt s bnh nhn t hiu qu hn, khi tng
liu l 25mg, liu ti a mi ngy l 25mg.

- Ngi ln: Thoi khp & vim khp dng

thp 10 mg/ngy.
- Thng kinh nguyn pht 20 mg x 2 ln/ngy.

Ti Liu Tham Kho

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