I.

i cng
T dc r lm cho vin r nhanh v r mn, gii phng ti a b mt tip
xc ban u ca tiu phn DC vi mi trng ha tan, to iu kin cho qu
trnh hp thu dc cht.
T dc siu r tan r nhanh hn vi nng nh hn, khong 1-10%
(w/w). trong cng thc, t dc siu r cn lm tng kh nng nn, tng
tng thch vi cng thc liu cao
VD: crosscarmellose, crosspovidone,..

II. Phn loi, ngun gc, bn cht ha hc

TD siu r c ngun gc t nhin, tng hp, bn tng hp v Co-processed
v bn tng hp: sodium starch glycolate,
crosscarmellose, crosspovidone, Resins, L-HPC
Tng hp

u im ca Superdisintegrant tng hp v bn tng hp:

- Hiu qu nng thp hn so vi tinh bt.
- t nh hng n kh nng nn v trn chy .
- Hiu qu hn trong ht
Hn ch Superdisintegrant tng hp
- Ht m nhiu (nh hng n cc DC nhy cm m).
- Mt s cht l anion v c th to lin kt nh trong ng nghim vi cc thuc
cation (khng nh hng in-vivo).
- mi trng acid lm gim ng k t l hp th cht lng v hot ng ca
sodium starch glycolate v natri crosscarmellose, tr Crospovidone.
- Mc trng n Primojel (sodium starch glycolat) v Polyplasdone XL101
(crosspovidone) b gim khi to ht t. cng ion mi trng nh hng xu
n kh nng trng n ca crosscarmellose
T nhin: r, ngun cung cp nhiu, khng gy kch ng, khng c hi trong t
nhin, c kh nng t phn hy
Gm gum v cht nhy
Cht nhy t ht Plantago ovata , cht nhy t cy Lepidium sativum , Hibiscus
rosa-sinensis Linn. Mucilage, Mango Peel Pectin

Kiu cu trc
(tn)

M t

Tn thng mi (nh sn
xut)

1. Tinh bt bin
tnh (sodium
starch glycolate)

Sodium carboxymethyl
starch; cc nhm
carboxymethyl lm
tng tnh thn nc v
cc lin kt cho lm
gim tan.

Explotab (Edward Mendell C

o.)
Primojel (Generichem Corp.)
Tablo (Blanver, Brazil)

2. Cellulose bin
tnh
(croscarmellose)

Sodium carboxymethyl
cellulose; cc lin kt
cho lm gim tan.

AcDiSol (FMC Corp.)

Nymcel ZSX (Nyma, Netherl
ands)
Primellose (Avebe, Netherlan
ds)
Solutab (Blanver, Brazil)

3. Cross-linked
polyvinylpyrrolidone
(Crospovidone)

Cross-linked
polyvinylpyrrolidone;
khi lng phn t ln
v cc lin kt cho lm
gim tan.

Crospovidone M (BASF Cor

p.)
Kollidon CL (BASF Corp.)
Polyplasdone XL (ISP Corp.)

T nhin

EMCOSOY

4. Calcium
Silicate
5. soy
phollysaccharide

Khng cha tinh bt v

ng nn sd trong sn
phm dinh dng
SATIALGINE

6. Cross-linked
alginic acid
7. Gallen Gum

Anion polysaccharide
ca tetrasaccharides
mch thng do
Pseudomonas elodea
tng hp, kh nng r
tt tng t nh tinh
bt bin tnh v
celluloses.

KELCOGEL

8. Xanthan Gum

Tng hp t
Xanthomonas
campestris, t c
khuynh hng to gel,
r c ch trng n,

GRINSTED XANTHANSM

KETROL CG
XANTURAL

III.
IV. C ch tc dng
C 4 c ch ch yu
1. Trng n ( swelling)
Khi tip xc vi nc, t dc siu r trng n, tng th tch nhanh chng v ph
v cu trc ca vin

2. Vi mao qun (wicking/capillary)

VD: sodium starch glycolate & crospovidone
3. Bin dng (deformation recovery)
VD: crosspovidone, starch

4. y nhau (repulsion)
Nc vo trong cc l .Cc tiu phn TD siu r mang in v to ra lc y nhau
VD: Na starch glyconat
Trn thc t, 1 loi t dc siu r r theo nhiu c ch khc nhau, vin nn r
c do s kt hp ca nhiu c ch vi nhau.
V. NG DNG TRONG CC LOI VIN NN C BIT
T dc siu r c dng trong vin nn phn tn trong ming, vin phn tn
nhanh, vin t di li, vin r nhanh, ha tan nahnh, gii phng nhanh

VI. Kt lun
Mc d c rt nhiu t dc siu r, vi kh nng r rt tt, nhng vic tm kim
cc TD siu r mi vn ang tip tc v cc nh nghin cu ang th nghim vi
cc sn phm t nhin bin tnh nh formalincasein, chitin, chitosan, thch polyme
acrylamide, xylan, Smecta, key-jo-clay, carboxymethylguar crosslinked v tinh bt
sn bin tnh.