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Term 1

Definition 1

Methylphenidate

AKA: Ritalin
Mech: incr. NE vesicular release (like
amphetamines)
Use: ADHD

Term 2

Definition 2

Haloperidol

Antipsychotic
(others: trifluperazine, fluphenazine, thioridazine)
Mech: D2 antag
Use: Schizo (pos. sx)psychosis, mania, Tourette's
Tox: EPS SE (dystonia akinesia akathisia
tardive dyskinesia); galactorrhea (incr. PRL); anti-M/
/His effects; neuroleptic malign synd - rigidity,
myoglobinuria, autonomic instab., high fever (tx:
dantrolene, DA ags)

Term 3

Definition 3

Chlorpromazine

Antipsychotic (others: haloperidol, trifluperazine,

fluphenazine, thioridazine)
Mech: D2 antag
Use: Schizo (pos. sx), psychosis, mania, Tourette's
Tox: EPS SE (dystonia akinesia akathisia
tardive dyskinesia); galactorrhea (incr. PRL); anti-M/
/His effects; neuroleptic malign synd - rigidity,
myoglobinuria, autonomic instab., high fever (tx:
dantrolene, DA ags)

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Term 4

Definition 4

Clozapine

Atypical antipsychoticMech: block 5-HT2, , H1, & DA

RsUse: schizo (pos. & neg. sx)Tox: Fewer EPS &
anti-M effects than traditional antipsychs

Term 5

Definition 5

Olanzapine

Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx); OCD, anx, depr, mania,
Tourette's'
Tox: Fewer EPS & anti-M effects than traditional
antipsychs

Term 6

Definition 6

Risperidone

Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA Rs
Use: schizo (pos. & neg. sx)Tox: Fewer EPS & anti-M
effects than traditional antipsychs

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Term 7

Definition 7

Aripiprazole

Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx)
Tox: Fewer EPS & anti-M effects than traditional
antipsychs

Term 8

Definition 8

Quetiapine

Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx)
Tox: Fewer EPS & anti-M effects than traditional
antipsychs

Term 9

Definition 9

Ziprasidone

Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx)
Tox: Fewer EPS & anti-M effects than traditional
antipsychs

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Term 10

Definition 10

Use: bipolar (blocks relapse & acute mania); SIADH

Lithium

Tox (narrow TI): tremor, hypothyr, polyuria (ADH

antag nephrogenic DI), teratogenesis

Term 11

Definition 11

Buspirone

Mech: 5-HT1A ag
Use: generalized anx d/o
Note: does not cause sedation, addiction, or additive
depression w/ alc; low abuse pot.

Term 12

Definition 12

Imipramine

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression, bedwetting (imipramine)
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox

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Term 13

Definition 13

Amitriptyline

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox",1,1

Term 14

Definition 14

Desipramine

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: least sedating, anti-M effects (3o amitriptyline >
2o nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox

Term 15

Definition 15

Nortriptyline

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox

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Term 16

Definition 16

Clomipramine

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression, OCD (clomipramine)
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox

Term 17

Definition 17

Doxepin

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox

Term 18

Definition 18

Amoxapine

TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox

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Term 19

Definition 19

Fluoxetine

SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect

Term 20

Definition 20

Paroxetine

SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect

Term 21

Definition 21

Sertraline

SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect

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Term 22

Definition 22

Citalopram

SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect

Term 23

Definition 23

Bupropion

Antidepressant (AKA: wellbutrin)

Mech: incr. NE & DA
Use: depr, smoking cessation
Tox: stimulant, seizure in bulimic
Note: no sexual SE

Term 24

Definition 24

Venlafaxine

Antidepressant
Mech: inhibs 5-HT, & NE reuptake
Use: depr, generalized anx d/o
Tox: incr. BP, stimulant

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Term 25

Definition 25

Duloxetine

Antidepressant
Mech: inhibs NE>5-HT reuptake
Use: depr, DM periph neuropathy
Tox: incr. BP, stimulant

Term 26

Definition 26

Mirtazapine

Antidepressant
Mech: 1) 2 antag incr. NE & 5-HT release;
2) 5-HT2 & 5-HT3 antag
Tox: sedation, incr. appetite

Term 27

Definition 27

Maprotiline

Antidepressant
Mech: blocks NE reuptake
Tox: sedation, ortho hypoTN

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Term 28

Definition 28

Trazodone

Antidepressant
Mech: inhibs 5-HT reuptake
Use: insomnia (extremely high dose req'd for depr)
Tox: sedation, nausia, priapism

Term 29

Definition 29

MAO-I
Mech: blocks MAO incr. DA, NE, Epi
Use: depr, anx, hypochondriasis
Phenelzine
Tox: hypertensive crisis w/ tyramine & -agContra:
SSRIs (5-HT synd), meperidine (active metabolite
seizures)

Term 30

Definition 30

Tranylcypromine

MAO-I
Mech: blocks MAO incr. DA, NE, Epi
Use: depr, anx, hypochondriasis
Tox: hypertensive crisis w/ tyramine & -agContra:
SSRIs (5-HT synd), meperidine (active metabolite
seizures)

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