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Term 1
Definition 1
Methylphenidate
AKA: Ritalin
Mech: incr. NE vesicular release (like
amphetamines)
Use: ADHD
Term 2
Definition 2
Haloperidol
Antipsychotic
(others: trifluperazine, fluphenazine, thioridazine)
Mech: D2 antag
Use: Schizo (pos. sx)psychosis, mania, Tourette's
Tox: EPS SE (dystonia akinesia akathisia
tardive dyskinesia); galactorrhea (incr. PRL); anti-M/
/His effects; neuroleptic malign synd - rigidity,
myoglobinuria, autonomic instab., high fever (tx:
dantrolene, DA ags)
Term 3
Definition 3
Chlorpromazine
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Term 4
Definition 4
Clozapine
Term 5
Definition 5
Olanzapine
Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx); OCD, anx, depr, mania,
Tourette's'
Tox: Fewer EPS & anti-M effects than traditional
antipsychs
Term 6
Definition 6
Risperidone
Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA Rs
Use: schizo (pos. & neg. sx)Tox: Fewer EPS & anti-M
effects than traditional antipsychs
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Term 7
Definition 7
Aripiprazole
Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx)
Tox: Fewer EPS & anti-M effects than traditional
antipsychs
Term 8
Definition 8
Quetiapine
Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx)
Tox: Fewer EPS & anti-M effects than traditional
antipsychs
Term 9
Definition 9
Ziprasidone
Atypical antipsychotic
Mech: block 5-HT2, , H1, & DA
Use: schizo (pos. & neg. sx)
Tox: Fewer EPS & anti-M effects than traditional
antipsychs
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Term 10
Definition 10
Term 11
Definition 11
Buspirone
Mech: 5-HT1A ag
Use: generalized anx d/o
Note: does not cause sedation, addiction, or additive
depression w/ alc; low abuse pot.
Term 12
Definition 12
Imipramine
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression, bedwetting (imipramine)
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox
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Term 13
Definition 13
Amitriptyline
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox",1,1
Term 14
Definition 14
Desipramine
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: least sedating, anti-M effects (3o amitriptyline >
2o nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox
Term 15
Definition 15
Nortriptyline
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox
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Term 16
Definition 16
Clomipramine
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression, OCD (clomipramine)
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox
Term 17
Definition 17
Doxepin
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox
Term 18
Definition 18
Amoxapine
TCA
Mech: NE & 5-HT reuptake blocker
Use: depression
Tox: sedation, anti-M effects (3o amitriptyline > 2o
nortriptyline); convulsions, coma, arrhythmias,
confusion/halluc. in elderly d/t anti-M (use
nortriptyline)
Antidote: NaHCO3 for CV tox
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Term 19
Definition 19
Fluoxetine
SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect
Term 20
Definition 20
Paroxetine
SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect
Term 21
Definition 21
Sertraline
SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect
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Term 22
Definition 22
Citalopram
SSRI
Mech: 5-HT reuptake inhib
Use: depression, OCD
Tox (less than TCAs): GI, anorgasmia, 5-HT synd w/
MAO-I (hyperthemia, rigidity, CV collapse, flushing)
Note: 2-3 wks for effect
Term 23
Definition 23
Bupropion
Term 24
Definition 24
Venlafaxine
Antidepressant
Mech: inhibs 5-HT, & NE reuptake
Use: depr, generalized anx d/o
Tox: incr. BP, stimulant
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Term 25
Definition 25
Duloxetine
Antidepressant
Mech: inhibs NE>5-HT reuptake
Use: depr, DM periph neuropathy
Tox: incr. BP, stimulant
Term 26
Definition 26
Mirtazapine
Antidepressant
Mech: 1) 2 antag incr. NE & 5-HT release;
2) 5-HT2 & 5-HT3 antag
Tox: sedation, incr. appetite
Term 27
Definition 27
Maprotiline
Antidepressant
Mech: blocks NE reuptake
Tox: sedation, ortho hypoTN
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Term 28
Definition 28
Trazodone
Antidepressant
Mech: inhibs 5-HT reuptake
Use: insomnia (extremely high dose req'd for depr)
Tox: sedation, nausia, priapism
Term 29
Definition 29
MAO-I
Mech: blocks MAO incr. DA, NE, Epi
Use: depr, anx, hypochondriasis
Phenelzine
Tox: hypertensive crisis w/ tyramine & -agContra:
SSRIs (5-HT synd), meperidine (active metabolite
seizures)
Term 30
Definition 30
Tranylcypromine
MAO-I
Mech: blocks MAO incr. DA, NE, Epi
Use: depr, anx, hypochondriasis
Tox: hypertensive crisis w/ tyramine & -agContra:
SSRIs (5-HT synd), meperidine (active metabolite
seizures)
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