C.

TEÁ BAØO T VAØ ÑAÙP

ÖÙNG MIEÃN DÒCH QUA
TRUNG GIAN TEÁ BAØO.
I. Lympho baøo T
1. Nguoàn goác vaø quaù trình bieät hoaù
2. Phaân loaïi lympho baøo T
– Teá baøo T4:
Teá baøo T hoã trôï (TH)
Teá baøo T quaù maãn chaäm (TDTH)
– Teá baøo T8
Teá baøo T ñoäc (Tc)
Teá baøo T kìm haõm (Ts)
The cellular organization of the human
thymus
Thymocytes at different stages are found in
distinct parts of the thymus
 The role of effector T cells in cell-mediated and humoral
immune response to representative pathogen
Cell mediated immunity Humoral immunity

Vaccinia virus Mycobacterium

Clostridium tetani
Typical tuberculosis
Influenza virus Staphylococcus
pathogen Mycobacterium
Rabies virus aureus
leprae

Location Cytosol Macrophage vesicles Extracellular fluid

Effector Cytotoxic CD8 T

TH1 cell TH2/TH1 cell
T-cell cells

Antigen Peptid:MHC class I on Peptid:MHC class II on Peptid:MHC class II on

recognition infected cells infected macrophages antigen specific B cell

Activation of specific
Effector Killing of infected Activation of infected
B cell to make
action cells macrophages
antibody
3. Thuï theå teá baøo lympho T
Sô löôïc veà caáu truùc phaân
töû TCR
Vai troø cuûa TCR trong ñaùp
öùng mieãn dòch ñaëc hieäu
Cô sôû gene hoïc tính ña daïng
cuûa TCR
The germline organization of the
human T-cell receptor αand βloc
i
T-cell receptor α- and β-chain gene rea
rrangement and expression
II. PHÖÙC HÔÏP HOAØ HÔÏP MOÂ
CHUÛ YEÁU vaø TEÁ BAØO
TRÌNH DIEÄN KHAÙNG
NGUYEÂN
Phöùc hôïp hoaø hôïp moâ chuû yeáu
– Khaùi nieäm
– Phaân loaïi MHC
– Phaân boá vaø chöùc naêng cuûa MHC
Teá baøo trình dieän khaùng nguyeân
– Macrophage
– B-lymphocyte
– Teá baøo hình sao (Dendritic cells)
 The expression of MHC mollecules
differs between tissues
Tissue MHC Class I MHC Class II
Lymphoid Tissues
T cells +++ +
B cells +++ +++
Macrophages +++ +++
Other Antigen Presenting cells +++ +++
Epithelial cell of thymus + +++
Other nucleated cells
Neutrophils +++ _
Hepatocytes + _
Kidney + _
Brain + _
Non-nucleated cells
Red blood cells _ _
Self Recognition of NK Cells
Non-self Recognition of NK Cells