Nifedipin c tc dng trnh thai?

Nhiu ngi bit nifedipin l thuc h huyt p v cha chng au na u (migraine), thuc nhm chn calci, dng hng ngy v c n 6 hng bo ch ln sn xut thuc ny. Bc s Susan Benoff ca Bnh vin North Shore thuc Trng i hc tng hp New York, M l ngi u tin nhn thy nifedipin c tc dng trnh thai vo nm 1952 khi mt cp v chng iu tr him mun nhiu ln th tinh trong ng nghim nhng tht bi. Khi soi tinh trng di knh hin vi thy hnh th c v bnh thng nhng lm cc test khc li thy tinh trng thiu mt cht ha hc c tc dng kt ni quan trng l mannose lectin v mng tinh trng c lng cholesterol cao hn bnh thng. Khi ngi chng chuyn sang dng loi thuc h huyt p khc th nng cholesterol mng tinh trng gim i nhiu v cp v chng th thai c trong vng vi thng. Bc s Benoff cng nghin cu mt s trng hp him mun khc trc y c nguyn nhn b n v thy cc ng chng u c dng nifedipin. Thuc chn calci c tc dng chn phn no knh calci cc t bo ca tim v mch mu (knh calci iu ha cc ion calci i qua mng t bo). Nhng knh calci ny l nhng "ca" c in th thp c kh nng xuyn qua mng t bo chuyn cc tn hiu in cho cc c c co hay gin. Cc thuc chn calci lm cho tc trao i calci gim i v lm cho cc c ca h tun hon gin ra v v th huyt p gim. Cc thuc chn calci cng phn no ngng hm cc knh calci bn trong mng t bo ca tinh trng v v th nh hng n hot ng ca tinh trng ch khng phi l s sn xut ra tinh trng. Nam gii dng nifedipin vn to ra lng tinh trng bnh thng v cc tinh trng c v vn hot ng bnh thng khi xem di knh hin vi nhng cc test li cho thy nhng tinh trng ny khng th th tinh cho trng. Cc nh khoa hc trong labo ca bc s Benoff quan st thy tinh trng ca nam gii dng nifedipin c nng thp mannose lectin mng t bo, mt cht rt quan trng kt hp vi mng ngoi ca trng. iu tr bng nifedipin c th ngn cn mannose lectin di chuyn ti b mt ca mng t bo bng cch lm cho mng tr nn cng rn do c qu nhiu cholesterol bm vo. Cc nh khoa hc cng nhn thy c th c nhiu hn mt tp knh calci mng tinh trng v nhng tp ny cn tnh n khi ch to thuc. Cho ti nay vn cha c th nghim lm sng no chng minh cc thuc chn knh calci c tc dng trnh thai cho nn cha c cu tr li chc chn cho vn ny. Trong khi hiu qu ca nifedipin trn thc nghim c chng minh nhng cc nh nghin cu khc li chng minh rng bnh nhn cc khoa him mun khc vn khng ngng dng thuc chn calci m vn t kt qu th tinh. V cc thuc chn calci khng lm thay i tin trnh to ra tinh trng nn nam gii t dng nifedipine trnh thai khng th da vo s lng tinh trng nh gi hiu qu trnh thai. Ch c cc test nh gi v chc nng tinh trng ti cc khoa him mun mi c kh nng o lng c hiu qu trnh thai ca nifedipin nhng gi thnh rt t (khong t 300 - 600USD). V khng c th nghim lm sng v hiu qu trnh thai ca nifedipin cho nn liu lng no th c tc dng trnh thai cng vn l mt b n. Bnh nhn dng thuc chn calci h huyt p vi liu lng khc nhau v tc dng ph ty thuc vo liu lng. C nhiu loi thuc chn calci v liu lng dng cng rt khc nhau th iu c ngha l tc dng ph cng rt a dng nhng thng gp nht ( 2 - 12% s ngi dng) l ph n ngoi

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Nifedipin c tc dng trnh thai?

bin (cc chi), nhc u nh, nng bng mt v bun nn. Cc thuc chn calci khng i km vi bt c tc dng no n hormon hay libido (dc nng). Nifedipin c mt trn th trng hn 20 nm v an ton c xc nh, tuy nhin nu nam gii c huyt p bnh thng m dng nifedipin trnh thai th phm vi v mc ca cc tc dng ph c th khc. Ti nay, nifedipin cha c dng th nghim trn nam gii c huyt p bnh thng hay thp. Cc hng dc phm khng quan tm nghin cu v tc dng trnh thai ca nifedipin v 2 l do: khng mun khch hng bit v tc dng trnh thai ca nifedipin, nh th s lm gim doanh s bn nifedipin nh l thuc h huyt p. Thuc nifedipin ang tr thnh thuc c sn xut cng khai (ht thi hn bo v tc quyn) nn nhiu hng dc khc sn xut thuc, cc hng ln cng khng c li g nu tip tc b tin ra nghin cu v tc dng trnh thai ca nifedipin. C l phi n nm 2016 th bc s Benoff mi c giy php cng nhn nifedipin c tc dng trnh thai. (SKDS)

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