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Predisposing Precipitating
Factors: Factors:
Thickening and/or an
in the amount of collagen in
the basement membranes
of the small vessels
Glomerulosclerosis
GFR
(Glomerular Filtration Rate)
proteinuria
Renal blood
Stage I
DIMINISHED RENAL
RESERVE
GFR 50%
Normal BUN,
creatinine
Stage II
RENAL INSUFFICIENCY
GFR 20-50%
BUN, creatinine
levels begin to rise
Hypertrophy of
nephrons
Further damage of
the nephrons
80-90% damage
Stage III
RENAL FAILURE
GFR 10-20%
Impaired kidney
function and
Uremia