Cng ngh sinh hc Cc lin kt trong phn t Protein : Lin kt peptit gia cc axit amin (aa) Lin kt hydro

ydro Lin kt disulfide Lin kt cu mui

c im cu trc ca Protein : Cu trc bc mt ca protein l s lng v trnh t sp xp ca cc aa to thnh mch polypeptit. Cc aa trong chui polypeptit c ni vi nhau bi lin kt peptit (lin kt cng ho tr).

Hnh : cu trc bc 1 Cu trc bc 2 ca protein l cu trc chu k ca chui polipeptit. Nm 1951, Pauling v Corey a ra 2 kiu cu trc bc 2 chnh ca chui polipeptit l cu trc xon v cu trc gp np .

+ Cu trc xon L cu trc mch polipeptit xon cht li tng t l xo, nhng nhm peptit (-CO-NH-) v C to thnh phn bn trong (li) ca xon cn cc mch bn (nhm R) ca cc gc aa quay ra pha ngoi. + Trong cu trc phin gp np cc on mch polipeptit thng dui di ra khng cun xon cht nh xon .

Cu trc bc 3 L s sp xp va xon va gp khc mt cch dy c v phc tp ca chui polipeptit. Cu trc bc 4 cha t 2 chui polipeptit tr ln lin kt vi nhau thnh phc hp Pr ln hn. Vai tr ca protein : c 8 vai tr Protein c bit c hot tnh xc tc gi l cc enzym