M U Chng Mt.

TNG QUAN
1.1.

Gii thiu v glucosamin hydroclorua v mt s dn xut ca glucosamin hydroclorua

1.1.1. Cu trc ha hc, tnh cht l ha ca glucosamin hydroclorua 1.1.2. Dc l v dc ng hc ca glucosamin hydroclorua 1.1.3. Cu trc ha hc v tnh cht vt l mt s dn xut N-acyl v tetra-O-acylN-acyl

glucosamin
1.1.4. Dc l v dc ng hc ca mt s dn xut N-acyl v

tetra-O-acylN-acyl

glucosamin 1.2. Gii thiu v cht lng ion trong tng hp hu c

1.2.1. Tnh cht c trng ca cht lng ion (trang 149)

1.2.2. Nguyn tc tng hp cht lng ion 1.2.3. Tng hp cht lng ion h imidazolium 1.3. ng dng vi sng trong tng hp cht lng ion
1.3.1. Gii thiu chung v vi sng

1.3.2. u im 1.4. ng dng siu m trong tng hp hu c 1.4.1. Gii thiu v siu m 1.4.2. u im ca siu m Chng Hai. NGHIN CU 2.1. Ni dung nghin cu
Tng hp mt s dn xut ca glucosamin c ng dng trong dc phm t glucosamin hydroclorua:

- Tng hp dn xut N-propionyl glucosamin t glucosamin clorua (QG1) - Tng hp dn xut N-phthaloyl glucosamine t glucosamin clorua(QG6) - Tng hp dn xut 1,3,4,6-tetra-O-propionyl-N-acetyl glucosamin (QG2) - Tng hp dn xut 1,3,4,6-tetra-O-phthaloyl-N-acetyl glucosamin (QG3) - Tng hp dn xut 1,3,4,6-tetra-O-propionyl-N-butyl glucosamin (HG6) - Tng hp dn xut 1,3,4,6-tetra-O-phtaloyl -N-butyl glucosamin (QG7)(ang tng hp) - Tng hp dn xut 1,3,4,6-tetra-O-acetyl-N-phtaloyl glucosamin (QG8)(ang tng hp) - Tng hp dn xut 1,3,4,6-tetra-O-propionyl-N-phtaloyl glucosamin (QG4) - Tng hp dn xut 1,3,4,6-tetra-O-butyryl-N-phtaloyl glucosamin (QG5)

- Tng hp dn xut 1,3,4,6-tetra-O-acetyl-N-propionyl glucosamin - Tng hp dn xut 1,3,4,6-tetra-O-butyryl-N-propionyl glucosamin - Tng hp dn xut 1,3,4,6-tetra-O-phtaloyl-N-propionyl glucosamin 2.2. Phng php nghin cu 2.3. Kt qu v tho lun Chng Ba. THC NGHIM 3.1. Dng c, thit b, ha cht th nghim 3.1.1. Dng c 3.1.2. Thit b 3.1.3. Ha cht 3.2. Tinh ch mt s ho cht 3.3. Pha ch ho cht phc v th nghim 3.4. Tng hp cht lng ion 3.5. Tng hp mt s dn xut ca glucosamin hydroclorua 3.5.1. Tng hp dn xut N-propionyl glucosamin t glucosamin clorua (QG1) 3.5.2. Tng hp dn xut N-phthaloyl glucosamine t glucosamin clorua(QG6) 3.5.3.Tng hp dn xut 1,3,4,6-tetra-O-propionyl-N-acetyl glucosamin (QG2) 3.5.4. Tng hp dn xut 1,3,4,6-tetra-O-phthaloyl-N-acetyl glucosamin (QG3) 3.5.5. Tng hp dn xut 1,3,4,6-tetra-O-propionyl-N-butyl glucosamin (HG6) 3.5.6. Tng hp dn xut 1,3,4,6-tetra-O-phtaloyl -N-butyl glucosamin (QG7)(ang tng hp) 3.5.7. Tng hp dn xut 1,3,4,6-tetra-O-acetyl-N-phtaloyl glucosamin (QG8) (ang tng hp) 3.5.8. Tng hp dn xut 1,3,4,6-tetra-O-propionyl-N-phtaloyl glucosamin (QG4) 3.5.9. Tng hp dn xut 1,3,4,6-tetra-O-butyryl-N-phtaloyl glucosamin (QG5) 3.5.10. Tng hp dn xut 1,3,4,6-tetra-O-acetyl-N-propionyl glucosamin 3.5.11. Tng hp dn xut 1,3,4,6-tetra-O-butyryl-N-propionyl glucosamin 3.5.12. Tng hp dn xut 1,3,4,6-tetra-O-phtaloyl-N-propionyl glucosamin KT LUN

KIN NGH TI LIU THAM KHO