M U Chng Mt.

TNG QUAN
1.1.

Gii thiu v glucosamin hydroclorua v mt s dn xut ca glucosamin hydroclorua

1.1.1. Cu trc ha hc, tnh cht vt l v ha hc ca glucosamin hydroclorua 1.1.2. Dc l v dc ng hc ca glucosamin hydroclorua 1.1.3. Cu trc ha hc, tnh cht vt l v dc ng hc mt s dn xut N-acyl

1.1.3.1.cc cng trnh nghin cu trong nc 1.1.3.2. cc cng trnh nghin cu nc ngoi ( ghi r ng phn no c hot tnh)
1.1.4. Cu trc ha hc, tnh cht vt l v dc ng hc mt s dn xut v tetra-O-acyl

N-acyl glucosamin
1.1.4.1. 1.1.4.2. 1.2.

cc cng trnh nghin cu trong nc cc cng trnh nghin cu nc ngoi( ghi r ng phn no c hot tnh) ng dng vi sng trong tng hp hu c

1.2.1. Gii thiu chung v vi sng

1.2.2. u im
1.2.3. ng dng vi sng trong mt s phn ng este ha

1.3.

ng dng siu m trong tng hp hu c

1.3.1. Gii thiu v siu m 1.3.2. u im ca siu m Chng Hai. NGHIN CU 2.1. Ni dung nghin cu Tng hp mt s dn xut ca glucosamin t glucosamin hydroclorua: 2.1. Tng hp dn xut N-acyl glucosamin t glucosamin hydroclorua: -Quy trnh tng hp - Xc nh cu trc sn phm: ph 1H, dim chy, quay cc - Siu m: thi gian, cng sut -Chiu x: time, cng sut -Khuy t: time, cng sut 2.2. Tng hp dn xut tetra-O-acyl-N-acyl glucosamin t glucosamin hydroclorua - Quy trnh tng hp - Xc nh cu trc sn phm: ph 1H,13C, IR, DEPT, HSQC, HMBC, dim chy,

quay cc - Siu m: thi gian, cng sut -Chiu x: time, cng sut -Khuy t: time, cng sut 2.3. Tng hp dn xut penta acyl glucosamin t glucosamin hydroclorua - Quy trnh tng hp - Xc nh cu trc sn phm: ph 1H,13C, IR, DEPT, HSQC, HMBC, dim chy, quay cc - Siu m: thi gian, cng sut -Chiu x: time, cng sut -Khuy t: time, cng sut 2.2. Phng php nghin cu - este ha bng phng php khuy t, siu m - este ha bng phng php vi sng 2.3. Kt qu v tho lun 2.3.1.este ha bng phng php khuy t so snh vi siu m v chiu x vi sng 2.3.1.1. este ha tng hp cc dx N-acyl glucosamin -hiu sut tng hp -d liu ph HG1,HG2,QG1,QG6 -bng t l ng phn , cc dx -> gii thch, kt lun 2.3.1.2.este ha tng hp cc dx tetra O-acyl- N-acyl glucosamin dx tetra O-acyl- N-acetyl glucosamin -hiu sut tng hp -d liu ph HG3,QG2 -bng t l ng phn , cc dx -> gii thch, kt lun dx tetra O-acyl- N-propionyl glucosamin -hiu sut tng hp -d liu ph QG7,QG8 -bng t l ng phn , cc dx -> gii thch, kt lun

 dx tetra O-acyl- N-butyryl glucosamin -hiu sut tng hp -d liu ph HG4,HG6 -bng t l ng phn , cc dx -> gii thch, kt lun dx tetra O-acyl- N-phtaloyl glucosamin -hiu sut tng hp -d liu ph QG11,QG4, QG5 -bng t l ng phn , cc dx -> gii thch, kt lun 2.3.1.2.este ha tng hp cc dx penta acyl glucosamin -hiu sut tng hp -d liu ph HG5,QG12 -bng t l ng phn , cc dx -> gii thch, kt lun Chng Ba. THC NGHIM 3.1. Dng c, thit b, ha cht th nghim 3.1.1. Dng c 3.1.2. Thit b 3.1.3. Ha cht 3.2. Tinh ch mt s ho cht 3.3. Pha ch ho cht phc v th nghim 3.5. Tng hp mt s dn xut ca glucosamin hydroclorua 3.5.1. Tng hp dn xut N-acyl glucosamin t glucosamin clorua - (QG1) - (QG6) 3.5.2. Tng hp dn xut dx tetra O-acyl- N-acyl glucosamin t glucosamin clorua -QG2 -QG7 -QG8 -HG6 -QG11

-QG4 -QG5 3.5.3. Tng hp dn xut penta-acyl glucosamin t glucosamin clorua -HG5 -QG12 KT LUN KIN NGH -th hot tnh khng vim, khng nm cc dx trn TI LIU THAM KHO