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Pharmaceutics - I
Aromatic waters are clear aqueous solution saturated with volatile Oils (e.g. rose oil, Peppermint oil, or other aromatic or volatile substances eg. camphor. Their odours and taste are of those of the drugs or volatile substances from which they are prepared. Aromatic waters may be used for perfuming, avoring or for special purposes for eg. 1. 2. Camphor water has been used as the vehicle in ophthalmic solutions owning to its ability to contribute refreshing, stimulating effect to the preparation. Hamamelis water known as witch hazel is employed as a rub, perfume and as an astringent in various cosmetic preparations, particularly in after-shave lotions.
1.
Distillation Method:
The distillation method involves the placing of the coarsely ground odoriferous portion of the plant or drug from which the aromatic water is to be prepared in a suitable still, with sufcient puried water. Most of the volume of water is then distilled. The excess oils collected with the distillate rises to the top of the aqueous product and are removed. The remaining aqueous solutions, saturated with volatile material require clarication by ltration.
2.
Solution Method:
Aromatic water is prepared by intermittently shaking 2ml (if liquid) or 2gm (if solid) of the volatile substance with 1000ml of puried water in suitable container for period of 15 minutes. After the period of agitation the mixture is set aside for 12 hours or longer to permit the excess oil and the solid substance to settle. Without further agitation the mixture is passed through a wetted lter paper and puried water added as needed to bring the volume of the ltrate upto the prescribed quantity.
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Pharmaceutics - I
Experiment No. 3
3.
By this method the volatile oil or suitably comminuted aromatic solid is thoroughly incorporated with 15gms of talc and to this mixture is added 1000ml of puried water. The resulting slurry is thoroughly agitated several times for the period of 30 minutes and then ltered.
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Experiment No. 3
Pharmaceutics - I
Experiment No. 3
1.0 Title:
To prepare, evaluate and submit 100ml of Chloroform Water I.P. by Simple Solution Method. (Read the Introduction of Aromatic Waters.)
2.0 3.0
Prior Concepts:
Different types of solutions, volumetric measurement
New concepts:
Proposition 1: Pharmaceutical Aid
Preparation used as an excipient or base or vehicle for formulation of other pharmaceutical preparations.
Proposition 2:
Proposition 3:
Storage: Aromatic waters are stored in air tight, light resistant container.
4.0
Learning objectives:
Intellectual Skills: To understand the concept of solubility. Motor Skills: Skill for measurement of volume.
5.0
Apparatus:
Glass Beaker (250 ml), Volumetric Cylinder (100 ml), Volumetric Pipette (1ml).
6.0
1. Chloroform I.P. 2. Puried water I.P. (q.s.) Required quantity Factor = Quantity given
2.5 ml 1000ml
7.0
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Pharmaceutics - I
Experiment No. 3
2.
Add sufcient quantity of puried water to make the required volume with constant stirring so that chloroform gets uniformly mixed. Dose: 15 to 30 ml Category: Pharmaceutical Aid. Storage: store in airtight container in cool place away from light.
8.0
Labeling of formulation:
(Students shall write all aspects of labeling in the space provided below.)
9.0
10.0 Result:
ml of .. preparation is submitted in . container with neat label.
11.0 Questions :
Answer Q. .... Q. .... Q. .... Q. .... (Question numbers to be allotted by the teacher.) 1. What are Aromatic waters? 2. Classify Aromatic waters on the basis of there strength. 3. State the solubility of Chloroform in water. 4. Dene Pharmaceutical Aids. 5. Write storage conditions for chloroform water with their signicance? 6. What is the concentration of chloroform in chloroform water? 7. State expiry date that you will mention for chloroform water?
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Experiment No. 3
Pharmaceutics - I
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