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against DENGUE
INFORMATION SHEET ON THE
You might be aware that the National Medical Research Council (NMRC) of Singapore has identified five major disease areas on which to focus research: cancer, eye disease, neuropsychiatric disease, metabolic disease and infectious disease. Dengue was selected out of the many infectious diseases because of its significant disease burden locally. This dengue research project is named STOP Dengue and it comprises a multi-disciplinary team of physicians, basic scientists and epidemiologists from many local institutions. The key objectives of STOP Dengue are to reduce disease burden, improve treatment and achieve the best management outcomes. STOP Dengue has a series of on-going clinical studies at the Communicable Disease Centre, Tan Tock Seng Hospital (CDC TTSH) as well as studies involving other major public hospitals. These clinical studies include detailed characterisation of acute dengue illness on a daily basis, identification of early diagnostic and prognostic markers, using non-invasive tests such as ultrsonography and endothelial elasticity measurements to assess disease severity, measurement of host immune response to dengue infection, and evaluation of the usefulness of platelet transfusion. The Dengue Research Clinic supports the dengue research activities at CDC TTSH. Under the Prospective Adult Dengue Study, we aim to recruit five thousand adult patients over five years with undifferentiated fever to characterize dengue infection in detail. Research is done in collaboration with many research institutes, such as the Environmental Health Institute which will carry out diagnostic and virological screening of samples, the Genome Institute of Singapore, which will perform viral and host genome analysis, and Duke-NUS Graduate Medical School which will undertake cytokine and coagulation profile determination. We are currently recruiting patients and you may be eligible to take part if you have a fever that you or your doctor suspects may be dengue. Please attend Specialist Outpatient Clinic J (SOC J) at the Communicable Disease Centre, Moulmein Road, Singapore 308433, where you will be seen by a doctor from the Department of Infectious Diseases. To find out about joining the study or for other information about our work, you may contact the Infectious Diseases Research Clinic by telephone: 63577442 or by email: <drc@ttsh.com.sg>.