OFLOXACIN DRUG CLASS AND MECHANISM: Ofloxacin is an antibiotic that is used to treat bacterial infections.

It belongs to the fluoroquinolone class of antibiotics. Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material (DNA). PRESCRIBED FOR: Ofloxacin is used to treat pneumonia and bronchitiscaused by Haemophilus influenzae and Streptococcus pneumoniae. It also is used in treating skin infections caused by Staphylococcus aureus, andStreptococcus pyogenes bacteria. Ofloxacin is used to treat sexually transmitted diseases, such as gonorrhea and chlamydia, but is not effective against syphilis. Ofloxacin is used often to treat urinary infections and prostate infections caused by E. Coli. Some strains of Streptococcus, Enterococcus, and anaerobic bacteria are resistant to ofloxacin. PREGNANCY: Ofloxacin should be avoided during pregnancy because it is secreted in breast milk and can cause adverse events in the infant. NURSING MOTHERS: Ofloxacin should be avoided in nursing mothers, as safe use has not been established. SIDE EFFECTS: The most frequent side effects of ofloxacin include nausea,vomiting, diarrhea, insomnia, headache, dizziness, itching, and vaginitis in women. Ofloxacin should be used with caution in patients with central nervous system diseases such as seizures because rare seizures have been reported in patients receiving this medication. Ofloxacin should be avoided in children and adolescents under 18 years of age, as safe use in these patients have not been established. Ofloxacin should not be used in patients with myasthenia gravis because it can increase muscle weakness.

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Metocloprami de

Antiemetic GI stimulant

Stimulates motility of upper GI tract without stimulating gastric, biliary, or pancreatic secretions; appears to sensitize tissues to action of acetylcholine; relaxes pyloric sphincter, which, when combined with effects on motility, accelerates gastric emptying and intestinal transit, little effect on gallbladder or colon motility; increases lower esophageal sphincter pressure; has sedative properties; induces release of prolactin.

-short- term therapy for adults with GERD -parenteral: prevention of nausea and vomiting -prophylaxis of postoperative nausea and vomiting when nasogastric suction is undesirable -treatment of nausea and vomiting of a variety of etiologies -contraindicated with allergy to metoclopramide, GI hemorrhage, mechanical obstruction or perforation, epilepsy. -use cautiously with previously detected breast cancer, lactation, pregnancy

CNS: restlessness, drowsiness, fatigue, insomnia, dizziness, anxiety CV: transient hypertension GI: nausea, diarrhea

-monitor BP carefully during IV administration -keep diphenhydramine injection readily available in case extrapyramidal reactions occur -have phenotolamine readily available in case of hypertensive crisis -take drug exactly as prescribed -use of alcohol, sleep remedies, or sedatives can cause serious sedation. -report involuntary movement of the face, eyes, and limbs

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NALBUPHINE

Narcotic agonistantagonist analgesic

Nalbuphine acts as an agonist at specific opioid receptors in the CNS to produce analgesia, sedation but also acts to cause hallucinations and is an antagonist at receptors

-Relief of moderate to severe pain -Preoperative analgesia, as a supplement to surgical anesthesia, and for obstetric analgesia during labor and delivery. -hypersensitivity to nalbuphine, sulfites; lactation. -Use cautiously with emotionally unstable clients or those with a history of narcotic abuse; pregnancy prior to labor, labor or delivery, bronchial asthma, COPD, respiratory depression, anoxia, increased intracranial pressure, acute MI when nausea and vomiting are present, biliary tract surgery.

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bisacodyl

Increases peristalsis & motor activity of the small intestines by acting directly on the smooth muscles.

Constipation, relief of evacuation in hemorrhoids, prep for barium enema, pre and post-op

Occasional abdominal discomfort, soreness in anal region

-monitor frequency & character of stool -monitor occurrence of adverse rxn -swallow the tablet whole, do not crush or chew

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