Methylcobalamin (MB12) Nasal Spray Summary - by: Stan Kurtz- Autism, ADHD, asthm a, eczema, and chronic fatigue

recoveryChildren's Corner MB12 Nasal Spray Summary Written by: Stan Kurtz - Father and Independent Researcher This is a DRAFT document - updated 03/16/07 About MB12 (Methylcobalamin) Nasal Spray MB12 Nasal Spray was developed by Stan Kurtz, an independent researcher and father of a child who recovered from autism. Stan does not financially benefit from the use of MB12 and does not have a known conflict of interest relating to the information in this document.. The first use of MB12 in the subcutaneous injection form was by Dr. James Neubrander, who through the work of Richard Deth Phd and Jill James Phd on oxidative stress and methionine synthase discovered it was helpful to many children with autism. Stan Kurtz had a philosophy of trying everything on himself that he would try on his son, and when he tried MB12 injections, it so happened that his symptoms of Irritable Bowel Syndrome and Attention Deficit where immediately greatly diminished. Through further research coordinated with Autism Research Institute, Stan discovered that intranasal administration of MB12 worked extremely well. There is also published literature that supports that intranasal spray of cobalamin vitamins is similar in efficacy to intravenous (IV) administration and that it can have a cobalamin normalizing effect that other administrations do not seem to have. Medical Literature Methylcobalamin has been documented in the medical literature to help improve oxidative status in children with autism (which likely does the same for many other conditions),it is said to be a novel antiviral for AIDS, helpful in fighting cancer, peripheral neuropathy, autonomic disregulation, it can help improve DNA methylation, nerve regeneration, and many other conditions. Observations Based on videos that Stan has published of trials of MB12, if the person is a MB12 Responder, it also appears to often (and at times dramatically) help with: ADHD symptoms Memory Anxiety Chronic fatigue Dyslexia Depth Perception Viewing Color Speech (finding words, apraxia, articulation, etc) Socialization Mood Behavior Sleep Regulation Depression Neurotransmitter function Autoimmune symptoms Chemical Sensitivity Digestion Viral Infections Inflammatory conditions like rheumatoid arthritis, sciatica, fibromyalgia Asthma Irritable bowel Colitis Eye or muscle "twittering" Tinnitus Nail bitting

Migraines Visual and auditory processing Modulation of light Night vision Improved ability to process sounds and modulate background noise Assisting in nerve growth Blocking the effects of ethanol Greatly reduces the desire for alcohol, coffee, marijuana, methamphetamines, and possibly many other addictive drugs and behavior. Effects of MB12 Nasal Spray Typically the effects of MB12 Nasal Spray begin to occur within minutes of the application. An experiment on QEEG activity showed that MB12 Nasal Spray worked almost instantly. On video, Stan has recorded many subjects feeling better in minutes and sometimes seconds. Besides autism, which can have both immediate and long-term benefits, most people report that any improvements from MB12 occur within the first hour of administration. The typical administration seems to last about 24 hours, but every person is different. Some people seem to become depleted of available MB12 in hours, others seem to feel the benefits for days. Quite often the need for MB12 Nasal Spray decreases as time goes on. Additionally, the reduction of milk and wheat products, lessening complex carbohydrates and starches and improvements to intestinal flora will commonly lessen the need for MB12. Some people have reported that their need for MB12 completely diminishes over time. QEEG Activity In March of 2006, MB12 Nasal Spray was shown to seemingly normalize brain waves of a 23 year old with DSM-IV Attention Deficit Disorder (ADD). Testing included pre testing and 3 post tests including one immediately after administration. All test showed a dramatic lessoning of theta wave activity (3.5-7.5 Hz), which is common in attention challenges, and activity in the entire brain increased, while the subject was observed to be more relaxed and attentive while ocular twittering was greatly reduced. A more detailed report of this experiment is available here. This experiment was monitored by Jack Johnstone PhD from Q-Metrx. QEEG theta wave activity before and after nasal MB12 UCLA Study of MB12 Nasal Spray Stan began meeting with the ADHD research team at UCLA to present his finding on MB12 Nasal Spray. After much work, an IRB approved pilot study of MB12 Nasal Spray is being conducted by UCLA for people with ADHD and addiction. SPECT Activity In March of 2007, MB12 Nasal Spray was shown to seemingly greatly improve brain blood flow of a 53 year old mom of two children with autism and personally stuggling with fibromyalgia, depression, and symptoms of brain fog, trouble finding words, memory issues, attention issues and several other chronic symptoms. Along with other possible abnormalities, the baseline test shows a significant amount of hypoprofusion (reduced blood flow) in the temporal, frontal and prefrontal lobes. In the post testing, this individual was sprayed with MB12 Nasal Spray 50 minutes prior to the SPECT isotope being administered. In addition to the obvious temporal lobe improvement, the frontal lobes dramatically normalized (see the black circle markers on the interactive view). This experiment was monitored by J. Michael Uszler M.D. at Santa Monica Imaging.

Why Intranasal? In an informal study, on location at Great Plains Laboratories , we were unable to raise MB12 levels significantly in individuals using sublingual

administration. Many anecdotal reports show that responders of MB12 Nasal Spray typically do not respond to sublingual or oral use. Out of thousands of MB12 reports from the group http://health.groups.yahoo.com/ only a few people have reported benefits from sublingual MB12. Some researchers suspect certain SNP and associated enzyme activity prevents the metabolism from gaining access to MB12 through sublingual or oral administration. We believe that a deficiency of certain types of bacteria in the intestinal flora and mucosa to have a possible role as well. Either way, intranasal MB12 is anecdotally suggested by users and suggested in the cobalamin medical literature. Intranasal vs. Shots In the adult community of ADHD and chronic illness we believe that intranasal spray is the best method of application. In the autism community it seems that there are four types of responders to MB12. 1. People who respond better to Nasal Spray MB12 2. People who respond better to Sub-Q (sub-cutaneous) Shot MB12 3. People who respond to either 4. People who respond to neither Dr. Jim Neubrander, the pioneer of the MB12 shot, believes that more children with autism will respond to the MB12 Sub-Q injection compared to MB12 spray. In our health group we see more reports of people with autism responding better to the spray. We have a new ongoing poll for people who wish to vote. These are the current standings comparing MB12 spray to shots (2/07). Our suggestion for people with autism is to consider a trial of both and see which works better for the particular child. For people with ADHD and other types of chronic illness, the spray is likely the best option. Nasal Spray Anecdotes In addition to the MB12 recovery videos at http://www.recoveryvideos.com/ that show almost instant improvement, there are hundreds of reports on our health web listserve and a short public list as well. Literally thousands of people have already tried MB12 Nasal Spray. Additional Symptoms That May Indicate Use White coated tongue, ocular stress (eye twittering), night vision challenges, food sensitivities, chemical sensitivities, fatigue, chronic stress, frequent viral infections, previous ear or throat infections, trouble sleeping or waking up in the morning, difficulty maintaining weight and... more to come. Family History That May Indicate Use Born to a mother who smoked during pregnancy or a close family member with autoimmune issues or cancer. Purchasing Today, many autism friendly and developmental disorders focused compound pharmacies carry MB12 nasal spray. The first pharmacy to compound MB12 for Stan was Coastal Compounding Pharmacy. http://www.coastalcompounding.com/ phone: 866.354.5188 fax: 912.355.3685. MB12 Nasal Spray presently requires a prescription when acquired in the United States. Doctors who typically agree to prescribe MB12 are doctors who are willing to try a non-medication remedy for illness. If your doctor does not wish to prescribe MB12 Nasal Spray, you can find a doctor who has commonly prescribed it for autism and related conditions a the Autism Research Institute s Website, US practitioners list http://www.autismwebsite.com/ARI/dan/danusdis.htm or outside the US at http://www.autismwebsite.com/ARI/dan/danforeigndis.htm MB12 is typically about $40 dollars for a bottle that lasts about 45-90 days based on the dosage and how often it is administrated.

Typical Dosing and Administration Note: I am not a doctor and I do not give out medical advice. I am the inventor of this therapy, but I am mainlly a parent who is just sharing information based on my own experience with my child and as a moderator of MB12Valtrex where many families talk about their experiences. Every person is different and should be treated as an individual. Some doctors have expressed a concern about me stating specific dosages of medications, so I will refrain from doing so in general terms. What I will do is mention some dosages that Coastal Compounding has made for different people. For specific dosing information, please speak to an enlightened, biomedically focused doctor. For a list of doctors please visit http://www.autism.com/ For Adults (commonly made by autism friendly compounding pharmacies) 1250mcg of MB12 together with 100mcg of folinic acid per .1ml spray once in each nostril once per day. MB12 is concentrated at 12.5mg/ml and the folinic is 1mg/ml Note: There is presently a study being conducted at UCLA for MB12 Nasal Spray for ADHD and the dosing for that study is 1250mcg of MB12 one spray in each nostril. For Children (commonly made by autism friendly compounding pharmacies) 625mcg of MB12 together with 50mcg of folinic acid once per day. We suggest taking MB12 after a meal, preferably breakfast (since it can provide a feeling of energy throughout the day). For young children who are sensitive to nasal sprays, some families administer it at night while the child is sleeping. Some people do initial trials later in the after noon when they begin to feel tired, so they can better feel the difference pre and post spray. Our original dosing was 1250mcg MB12 and 300mcg of folinic per spray. Some people believe that 300 mcg is preferred, but we have seen less reaction to folinic acid with starting at 100mcg. We believe people with autism may have a greater sensitivity (but still may have a need) for folinic acid and we strongly suggest starting at a lower doage of folinic (or just the MB12 by itself) before increasing the folinic dosage. Adjusting the Dosage for the Specific Individual For biochemical, physiological and environmental reasons, each person s need for MB12 is different. We suggest you use as little as you need to get the desired results. Using more does not mean better results. Taking a break from time to time or trying to space out your administration is a good practice to make sure you are not administering too much. Note Folinic Acid is typically a wonderful addition to methylcoblamin. It often aids in the utilization of MB12 and tends to hold it in the body for a greater period of time. That said, if any hyperactivity or negative symptoms seem to occur, you might want to try the spray without the folinic acid. Application Tips Prime the bottle before administration. If you can, tilt the head slightly downward so angle of bottle is vertical. Then squirt deep into the nasal passage so that little or no MB12 comes running out. The liquid is red like beets or blood, so if some drips out, it may look like blood. MB12 is very gentle and it is very unlikely it could cause a nosebleed. There are a certain amount of children with autism who frequently have nose bleeds (in general, not from MB12) and for those children you may want to consider supplementing with Vitamin K.

Some persons report having increased results when also supplementing with zinc, Omega 3 EFAs like Cod Liver Oil, other B Vitamins like B6 and P5P, B2, and B5, Calcium, Magnesium, Vitamin A, D, and K, Taurine and Selenium. If a child is ultra sensitive to sensory stimulus, you may want to leave the bottle out of the refrigerator before application of the spray or spray. Some people with sensitive children spray their child at night while they are sleeping. If an individual is encountering an acute illness or a particularly difficult acute set of symptoms, increasing a daily dose may be beneficial, but keep in mind that longer term use at a higher dosage may work against you. Reported Contraindications We do not know of contraindications of MB12, but we suspect MB12 and/or folinic acid may act as a potent anti-tumor agent, but may NOT be indicated for some people with certain types of leukemia. Possible Side Effects A minority of people encounter temporary hyperactivity after dosing MB12. Many people continue its use unless the hyperactivity continues. A small amount of people may not tolerate MB12 well and get headaches from usage, which we suggest discontinuing further use and trying other types of detoxification first. Other unlikely but possible indications that MB12 is not being well tolerated might include: Feeling cranky or sleepy, especially if taken on an empty stomach Feeling hyperactive, which may be a reaction to folinic. Typically this happens to a minority of children with autism. Rare nighttime incontinence with some autistic children (who we believe are detoxifying metals at the beginning of MB12 use). After reading about MB12 Nasal Spray and watching our recovery videos it may be a good idea to join our parent / researcher / clinician's recovery group and share your story about MB12, ask questions and get support from other families. Join Stan's online recovery group Disclaimer: None of this document s information has been approved by the Food and Drug Administration and it was written by a parent and independent researcher. This information is based on published medical literature and anecdotes, and should not be considered medical advice. Children's Corner Preschool 7023 Haskell Ave. Van Nuys, CA 91406 818-909-9489 web: http://www.childrenscornerschool.com/ email: info@childrenscornerschool.com