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QMU 3RD WEEK 1. Misoprostol protects the GIT mucosa by:a. Increase uterine contraction b. Releases aluminium c.

Increase mucus and bicarbonate ion d. Coats the mucosa 2. All the statements are concerning sucralfate except:a. Should be given with magnesium carbonates b. Forms gel to protect the mucosa c. Stimulates mucus secretion d. It does not cause systemic adverse effect 3. Which drugs is used against h. pylori:a. Sucralfate b. Cimetidine c. Misoprostol d. Bismuth chelate 4. The side effects of h pylori eradication therapy include:a. Constipation b. Other organism becomes more resistant c. Liver failure d. Kidney failure 5. In bismuth based drug regimen, the correct drug combination is :a. Bismuth, amoxicillin, ppi, metronidazole b. Bismuth, tetracycline, ppi, clarithromycin c. Bismuth, tetracycline, ppi, metronidazole d. Bismuth, tetracycline, sucralfate, omeprazole

6. Which of the following statements is true regarding gastric polyps? a. It occurs in older persons. b. They are classified into 2 types; Inflammatory and Auto-Immune type

c. They are common d. The polyps appear large, branching and often single. 7. All of the following are true about gastric carcinoma EXCEPT:a. Adenocarcinoma is the most common malignancy of the stomach b. Blood group AB are slightly associated as one of its risk factors. c. They occurred mainly in the pylorus and antrum d. It may be asymptomatic in early stage of carcinoma. 8. Malignant lymphoma is :a. Not responding well to chemotherapy b. Showing diffuse thickened of submucosal folds c. Associated with Helicobacter Pylori infection in the stomach d. Not showing any survival rate if localized to the stomach 9. Gasterointestinal Stromal Tumor (GIST) arises from :a. Parietal cells of the stomach b. Enteroendocrine cells c. Chief cells of the gastric glands d. Interstitial cells of Cajal 10. Sarcoma of the stomach can be presented clinically by: a. Bleeding b. Painful blisters c. Dysphagia d. Dyspnea 11. All of areas below not covered by peritoneum except.. a. Groove for IVC b. Tuber omental c. Porta hepatic d. Fossa for gall bladder 12. All of the statements are correct except.. a. Liver has 5 surfaces b. Located in the right iliac, hypogastric, and left iliac c. Right surface of the liver related to the 7-11 ribs

d. It is formed of right large and left small lobes 13. Liver drained by portal lymph nodes then into the coeliac lymph nodes except.. a. Caudate lobe b. Quadrate lobe c. Superior surface d. Bare area e. Renal impression 14. Inferior surface shows the following features except... a. Colic impression b. Fissure for ligamentum teres c. Fissure for ligamentum venosum d. Duodenal impression 15. Porta hepatis.. a. Anteriorly bounded by Caudate lobe b. Posteriorly bounded by Quadrate lobe c. Anteriorly bounded by Quadrate lobe Pharmacology Anti emetic and prokinetic Drug 16. All of the following are true about anticholinergic drugs except : a. Reduce the excitability of labyrinth receptors b. Used to treat postoperative nausea c. Useful in treating nausea caused by cancer chemotherapy d. Its cause drowsiness, blurred vision 17. Which is true about Histamine-1 receptor antagonist? a. Used in narcotic-induced vomiting b. Cause diarrhea and prolactin release c. Efficient in treating nausea of pregnancy d. Have prokinetic action. 18. All of these are true about Domperidone except: a. One of Dopamine antagonist b. Have prokinetic action c. Its poorly crosses the blood brain barrier

d. Have pyramidal side effect 19. All of these are true about therapeutic use of 5-HT antagonist except: a. Acute vomiting induced b. Pregnancy induce vomiting c. Postoperative vomiting d. Radiation induced vomiting 20. All of these are prokinetic drug except: A. Motilin B. Domperidone C. Metoclopramide D. Erythromycin E. Benzodiazepine 21. Portal system is formed by veins draining the GIT and lower limbs. [T/F] 22. Portal vein ascends behind the 2nd part of duodenum and in front of IVC before entering the liver together with the hepatic artery and bile duct. [T/F] 23. Tributaries of the splenic vein are :A. Splenic vein, short gastric vein, left gastroepiploic vein, right gastric vein B. Splenic vein, short gastric vein, pancreatic vein, paraumbilical vein C. Splenic vein, short gastric vein, left gastroepiploic vein, pancreatic vein, inferior mesenteric vein D. Splenic vein, left gastroepiploic vein, cystic vein, right gastroepiploic vein 24. Inferior mesenteric vein gives 3 tributaries, left, middle and right colic vein. [T/F] 25. There are ____ sites of portosystemic anastomosis. 26. Which of the following is false regarding the liver : a. Has both endocrine and exocrine functions b. It is a simple branched tubular gland c. A thin connective tissue capsule surrounded the liver d. The capsule is thicker at the hilum 27. By electron microscope, the hepatocytes show:

a. Few free ribosomes b. Smooth endoplasmic reticulum is rudimentary c. Short microvilli projecting from vascular side\ d. Attached to the neighbouring hepatocytes by desmosomes 28. All the following describing the hepatic blood sinusoids except : a. Have large diameter and lack of continuous basal lamina b. Lining by endothelial cells and Kupffer cells c. Endothelial cells have numerous fenestrae which lack of diaphragm d. Kupffer cells show many vacuoles, lysosomes, phagosomes and few mitochondria 29. The space of Disse contains i. Reticular fibers ii. Long, numerous microvilli from hepatocytes iii. Processes of Ito cells a. I and II b. II and III c. I and III d. All the above 30. All of the following is true regarding the gall bladder except : a. Hollow, pear shaped organ b. Its mucosa is highly folded, lined by simple columnar cells c. Lamina propria near the cystic duct contain serous secreting glands d. Its musculosa consists of smooth muscle fibers, collagen and elastic fibers 31. In hypovolemia, what is the main liver function to correct homeostasis? A. Blood reservoir b. Secrete erythropoietin c. Produce RBC d. Destroy RBC 32. At which semester does the liver function as a producer of RBC? A. 1st b. 2nd c. 3rd

33. RBC is destroyed in the liver. Which cell destroys RBC? A. Hepatocyte b. Endothelial cell c. Lymphocyte d. Kupffer 34. What is the function of mucin-like substance (component of bile) A. Protection b. Nutrition c. Waste product 35. The following are constituent of bile except? A. Water b. Lecithin c. Albumin d. Alkaline phosphatase 36. The body of pancreas is related posteriorly to the formation of portal vein. [T/F] 37. The head of pancreas is supplied by the superior and inferior pancreatico-duodenal arteries. [T/F] 38. The ampulla of Vater opens into the third part of duodenum. [T/F] 39. The head is related posteriorly to the IVC, renal veins and common bile duct. [T/F] 40. The uncinate process and lower part of the head drain into the main pancreatic duct. [T/F] 41. Which organelle is responsible for the basophilic staining of peripheral pancreatic acini ? A. Mintochondria B. Zymogen granules C. Rough endoplasmic reticulum D. Smooth endoplasmic reticulum

42. What is the functional unit of the liver? A. Portal lobule B. Liver acinus C. Classical hepatic lobule D. Portal tract 43. The secretory acini of the parotid gland is purely of mucous type. [T/F] 44. All the cells below are present in the neck region of fundic gland EXCEPT :A. Oxyntic cell B. Stem cell C. Mucous neck cell D. Entero-endocrine cell 45. The most numerous lingual papillae present in the tongue is A. Fungiform B. Filiform C. Circumvallate D. Folliate 46. All of the following are not true about bile salts EXCEPT:a. Hepatocytes synthesize about 0.2-0.4mg bile salts per day b. Lithocholate is relatively insoluble c. Lithocholate is mostly excreted in urine d. 90% of bile salts enter the colon and converted into salts of deoxycholic acid and lithocholic acid 47. Functions of bile salts:a. Activate lipase enzyme b. Facilitate water soluble vitamins and carotenes c. Ability to dissolve soluble fatty acid in water d. Direct antiseptic effect 48. Factors that control bile secretion :I. Bile pigments are the most powerful choleretics II. Secretin increasing its water and bicarbonate content III. Parasympathetic stimulation decrease bile secretion

IV. Increase intrahepatic vascular pressure will stop bile secretion a. I and II b. I,II and IV c. II and III d. II and IV 49. Micelles : a. Formed of cylindrical water-insoluble disk b. Contain fatty acids, phospholipids, and cholesterol only c. Provide mechanism for their transport to enterocytes d. Dissolved in liver 50. Cholagogues are I. Gall bladder evacuants II. Stimulants for bile secretion III. Relax sphincter of Oddi IV. MgSO4 is not a true cholagogues a. I and III b. II, III, and IV c. I and IV d. I,III, and IV e. III and IV 51. Enterically transmitted hepatitis virus are A. HAV and HEV B. HBV, HCV, HDV C. HAV only D. HBV and HDV 52. HAV causes severe chronicity in all age and mostly end by death [T/F] 53. Virus particles of HAV are found in saliva and transmitted by air. [T/F] 54. Anti-HAV IgG rises 3-6 weeks later and and gives passive immunity. [T/F] 55. Detection of anti-HAV IgM are used to confirm the diagnosis of acute hepatitis A. [T/F]

56. The normal concentration of bile pigments are :a. 0.2 0.8 g/100ml plasma b. 0.2 0.8 mg/dL plasma c. 0.02 0.08 mg/dL plasma d. 0.02 0.08 g/100ml plasma 57. All of the following are about the bile pigments EXCEPT :a. Bilirubin is the end product of hemoglobin and myoglobin metabolism b. It has digestive function c. The bilirubin combines with the albumin to form water insoluble compound called haembilirubin d. Cholebilrubin is catalyzed by glucoronyl transferase enzyme in the liver 58. Which one of the following is true regarding jaundice a. bluish discoloration of the skin, sclera and mucous membrane. b. detected clinically when the serum of bilirubin is between 0.8-2mg/100ml c. in hemolytic jaundice, the color of the urine is found to be dark brown d. there are three types of jaundice discovered until now 59. What are the possible causes of post hepatic jaundice? a. Excessive hemolysis of the RBC b. Disturbance of the intracellular protein conjugation c. Stone in the lumen of the bile duct that leads to its complete obstruction d. Mild obstruction of intrahepatic canaliculi 60. Regarding the fate of stercobilinogen :a. Urobilinogen is responsible for the normal color of the urine b. 2/3 of the total amount of stercobilinogen is reabsorbed by the enterohepatic circulation c. In the feces, of stercobilinogen is lost in the oxidized form d. The brown color of stool, is caused by the oxidized form of stercobilinogen that occur in the intestinal lumen or after exposure to the atmosphere.

ANSWER & REFERENCES 1. C ; page 70 2. A ; page 71 3. D ; page 71 4. B ; page 72 5. C ; page 72 6. B ; page 32 7. B ; page 32 8. C ; page 36 9. D ; page 37 10. A ; page 37 11. B ; page 97 12. B ; page 93 13. C ; page 94 14. C ; page 94 15. C ; page 95 16. C ; page 74 17. C ; page 75 18. D ; page 75 19. B ; page 76 20. E ; page 78 21. False ; page 90 22. False ; page 90 23. C ; page 91

24. False ; page 91 25. Six ; page 92 26. B ; page 132 27. D ; page 134 28. D ; page 134 29. D ; page 135 30. C ; page 138 31. B ; reference prof 32. A ; ref pg 42 33. D ; ref pg 42 34. A ; ref prof 35. C ; pg 44 36. False ; Pg 100 ; the neck of pancreas 37. True ; pg 101 38. False ; pg 101 ; the second part of duodenum 39. True ; pg 99 40. False ; pg 101 ; drain to the accessory duct 41. C ; page 131 42. B ; page 136 43. False ; page 130 44. D ; page 113 45. D ; page 106 46. B ; page 45 47. A ; page 45-47

48. D ; page 47 49. C ; page 46 50. D ; page 49 51. A ; page 61 52. False ; page 61 53. False ; page 61 54. False ; page 61 55. True ; page 62 56. B ; page 50 57. B ; page 50 58. D ; page 53 59. C ; page 53 60. D ; page 51

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