Fluconazole MSDS

Section 1 Chemical Product and Company Identification Product Name Catalog Codes CAS# RTECS TSCA CI# Synonym Chemical Name : : : : : : : : Fluconazole SLF1666 86366-73-4 XZ4810000 TSCA 8(b) inventory: No products were found. Not available. Fluconazole; Diflucan 2,4-Dfluoro-alpha, alpha-1-bis(1H-1,2,4triazol-1-ylmethyl)benzyl A 1H-1,2,4-Triazole-1-ethanol,alpha(2,4-difluorophenyl)-alpha-(1H-1,2,4triazol-1-ylmethyl)- l c o h o l o r Chemical Formula Contact Information : : C13-H12-F2-N6-O Sciencelab.com, Inc.14025 Smith Rd. Houston, Texas 77396 US Sales: 1-800-901-7247

International Sales: 1-281-441-4400

Section 2 Composition and Information on Ingredients Name Fluconazole CAS # 86366-73-4 % by Weight 100

Toxicological Data on Ingredients: Fluconazole: ORAL (LD50): Acute: 1271 mg/kg [Rat]. 1408 mg/kg [Mouse].

Section 3 Hazards Identification Potential Acute Health Effects : Slightly hazardous in case of skin Contact (irritant), of eye contact (irritant), of ingestion, of inhalation. CARCINOGENIC EFFECTS MUTAGENIC EFFECTS TERATOGENIC EFFECTS DEVELOPMENTAL TOXICITY : : : : Not available.

Not available. Classified.POSSIBLE for human. Not available. Repeated or prolonged exposure is not known to aggravate medical condition.

Section 4 First Aid Measures

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Eye Contact: Check for and remove any contact lenses. In case of contact , immediately flush eyes with plenty of water for atleast 15 minutes. Get medical attention if irritation occurs.

Skin Contact: Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Serious Skin Contact: Not available.

Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Serious Inhalation: Not available.

Ingestion: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious Ingestion Section 5: : Not available.

Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion : : : : : May be combustible at high temperature. Not available. Not available Not available. These products are carbon oxides (CO, CO2) Nitrogen oxides ( NO,NO2), halogenated compounds. Fire Hazards in Presence of Various Substances : Slightly flammable to flammable in presence of heat. Non flammable in presence of shocks. Explosion Hazards in Presence of Various Substances : Risks of explosion of product in presence of mechanical impact : not available. Risks of explosions of the product in Presence of static discharge : not available. Fire fighting Media and instructions : SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards : Not available.

Special Remarks on Explosion Hazards

Not available.

Section 6: Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large Spill: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage Precautions: Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label.

Storage:

Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 25C (77F).

Section 8: Exposure Controls/Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit.

Personal Protection: Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product.

Exposure Limits: Not available. Section 9:

Physical and Chemical Properties Physical state and appearance Odor Taste Molecular Weight Color pH (1% soln/water) Boiling Point Melting Point Critical Temperature Specific Gravity Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties Solubility : : : : : : : : : : : : : : : : : : Solid. (Crystalline solid.) Not available. Not available. 306.3 g/mole White. Not available. Not available. Not available. Not available. Not available. Not applicable. Not available. Not available. Not available. Not available. Not available. Not available.

Not available

Section 10:
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Stability and Reactivity Data Stability Instability Temperature Conditions of Instability Incompatibility with various Substances Corrosivity Special Remarks on Reactivity Special Remarks on Corrosivity Polymerization : : : : : Not available. Not available. Not available. Not available. Will not occur. : : : The product is stable. Not available. Excess heat.

Section 11: Toxicological Information Routes of Entry Toxicity to Animals : : Inhalation. Ingestion. Acute oral toxicity (LD50): 1271 mg/kg [Rat]. TERATOGENIC EFFECTS Other Toxic Effects on Humans : : Classified POSSIBLE for human. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

Special Remarks on Toxicity to Animals :

Not available.

Special Remarks on Chronic Effects on Humans: May cause birth defects (teratogenic). There are no adequate and well controlled studies of pregnant women. There have been reports of multiple congenital abnormalities in infants whose mothers wre being treated for 3 or more months with high doses (400-800 mg/day). Excreted in maternal milk in human.

Special Remarks on other Toxic Effects on Humans: Acute Potential Health Effects: Skin: Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause gastrointestinal tract irritation with nausea, vomiting, abdominal pain, diarrhea, dyspepsia, and tast perversion. May also affect behavior/central nervous system (headache, dizziness, seizures), metabolism (Hypercholesterolemia, Hypertriglyceridemia, Hypekalemia), liver, blood (leukopenia, neutropenia, agranulocytosis, thrombocytopenia), and cardiovascular system. Other symptoms may include skin rashes, exfoliative skin disorders such as Stevens-Johnson syndrome and toxic epidermal necrolysis and alopecia. Anaphylaxis in rare cases has been reported. Clincally or potentially significant drug interactioins between Fluconazole and the follwoing agents/classes have been observed: Oral hypoglycemics, Coumarintype anticoagulants, Phenytoin, Cyclosporine, Rifampin, Teheophylline, Terfenadine, Cisapride, Astemizole, Rifabutin, Tacrolimus.

Section 12: Ecological Information Ecotoxicity : Not available.

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BOD5 and COD Products of Biodegradation

: :

Not available. Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation : The products of degradation are as toxic as the product itself.. Special Remarks on the Products of Biodegradation : Not available.

Section 13: Disposal Considerations Waste Disposal: Waste must be disposed of in accordance with federal, state and local environmental control regulations.

Section 14: Transport Information DOT Classification : Not a DOT controlled material (United

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States) Identification Special Provisions for Transport : : Not applicable. Not applicable

Section 15: Other Regulatory Information Federal and State Regulations : TSCA 8(b) inventory: No products were found. Other Regulations Other Classifications : : Not available. WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC)

R22- Harmful if swallowed. R63-Possible risk of harm to the unborn child.

S2- Keep out of the reach of children. S46If swallowed, seek medical advice

immediately and show this container or label. HMIS (U.S.A.) Health Hazard Fire Hazard : : 1 1
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Reactivity Personal Protection

: :

0 E

National Fire Protection Association (U.S.A.) Health Flammability Reactivity : : : 1 1 0

Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 16: Other Information References Other Special Considerations Created Last Updated : : : : Not available. Not available. 10/09/2005 05:33 PM 06/09/2012 12:00 PM

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