Professional Documents
Culture Documents
By
Dr. Dorria Salem, Professor of Radiodiagnosis, Cairo University
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Anatomy
• The breast is a modified skin gland. It develops on the chest wall between the
clavicle and the 6th-8th ribs.
• Breast tissue can be found as far medially as the sternum and laterally to the
midaxillary line.
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Skin
• The skin of the breast is 0.5-2mm.thick. Just beneath the skin lies,the
superficial fascia that at the level of the breast divides into superficial &deep
layers. The breast develops between the split layer of fascia and is enveloped
by it.
• The deep layers of this split fascia forms the retromammary fascia; and this
lies immediately on the fascia that overlies the pectoralis.major.muscle
(prepectoral fascia)
• providing a surface that permit some movement of breast on the chest wall.
• BVs + lymphatics penetrate the fascial layers, coursing between the muscle&
the breast
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Subcutaneous fat
• Immediately beneath the skin is the subcutaneous fat. This layer varies with
individuals. In some females it is clearly separate from the parenchymal cone
of the breast. In others it cannot be distinguished from fat between the
glandular structures.
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Areola
The pigmented tissues of the areola contain numerous sweat and sebacous glands. The
skin of the areola is thicker than the rest of the breast skin; tapering down towards the
limbus of the areola. The small raised nodular structures that are distributed over the
areola are Morgagni’s tubercles and define the openings of Montgomery’s (sebacous)
glands.
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Nipple
There are between 8-20 major ducts that open on the nipple.
The width of each duct is 0.5-2mm
The ducts and its tributaries defines a lobe of the Breast. Beneath the nipple
openings; the major ducts dilate into their ampullary portions (lactiferous sinuses).
The deeper segmental ducts divide into subsegmental structures& may branch further
until they form the terminal duct that enters the lobule. A terminal duct & its lobule
are called “terminal duct lobular unit” TDLU. This can also be found as immediate
branches of the major ducts and are not always at the periphery.
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Blood supply
Arterial supply:
• Medial: internal mammary artery
• Lateral: axillary artery
lateral thoracic
thoracodorsal
intercostals
Venous drainage:
• Internal mammary v: direct communication with pulmonary capillary bed,
providing major routes for hematogenous metastases
• Axillary vein
• Intercostal vein: direct communication
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Lymphatic drainage
• Drainage from deeper tissues of the breast ∧ surface ∧ skin subareolar
plexus ∧ axilla
• Small % : drain to upper abdomen
medially to internal mammary lymphatics
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Supporting Structures
• The single layer of fascia that lies beneath the skin divides into deep and
superficial layers that form an envelope within which the breast develops.
• The breast is given structure by the fibrous tissues that surround and course
through it.
• The stromal, epithelial and glandular elements of the breast are held together
by an interlacing network of fibrous CT.
• This supporting network forms planar sheets of fibrous tissue that course
between the deep and superficial layers of fascia, incompletely
compartmentalizing the structures of the breast= cooper’s ligament.
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The Normal Breast:
Menstrual Variation, Lactation and Aging
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Imaging of the breast is further complicated by physiologic changes that occur in
relationship to the patient’s age and stage in the menstrual cycle.
The breast in young women is extremely dense and consists mostly of glandular
tissue.
In lactation, the glandular tissue is more dense.
In later part of menstrual cycle, the glandular tissue increases in density and
size:
As a woman ages, the glandular tissue is slowly replaced by fat
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Positioning
1. Craniocaudal (CC)
2. Mediolateral (ML)
3. Mediolateral Oblique (MLO)
4. Additional views:
a) Cone down compression
b) Magnified view
c) The breasts should be considered symmetrical organs.
d) Position the mammogram as mirror images
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Breast Ultrasonography
• Breast ultrasonography is an important, first diagnostic imaging modality that
is complementary with mammography. It should not be used for screening for
any age group, but when properly employed it can increase the overall
diagnostic accuracy of breast imaging.
• The important role of ultrasound is the differentiation of a cyst from a solid
mass. In this role, its accuracy is in the range of 96% to 100%
• US should be performed with 7.5-10 MHZ real time system.
• US has been recommended as the primary imaging technique for wome <
30yrs. with breast problems, this is because:
1. Lower prevalence of breast Ca
2. The breast , will be dense and poorly identified by mammography.
3. Susceptibility to radiation induced malignancy
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Indications
• Differentiation of cysts from solid masses
• Evaluation of a palpable mass not visible in radiographically opaque breast
• Evaluation of palpable mass in young patient
• Evaluation of an inflammed breast for the presence of an abscess
• Evaluation of a mass that cannot be completely evaluated by mammography
because of its deep location
• Guidance for interventional procedures
• For duplex color flow
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Benign lesion are usually sharply circumscribed where as malignant
lesions are usually irregular in shape
• A cyst should have no internal echoes even at high gain.
• The solid lesion may have distal enhancement. Although such solid lesions are
usually benign, cancer can do this as well.
• U.S. has been suggested as the initial imaging modality of choice in the young
(less than 30yrs of age) patient with palpable mass. If a cyst or a solid mass
cannot be identified, then a single view mammogram can be performed to
detect possible microcalcifications.
• It Is important to note that ultrasonography will not identify all solid masses,
especially in a fatty background except for a cyst.
• The use of doppler U.S. and color doppler may improve cancer detection by
demonstration of increased blood flow.
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Benign
Papilloma Lipoma
Duct ectasia Scarring&fat necrosis Fibroadenoma
Plasma cell mastitis Hamartoma Cysts
(Secretory deposits) Radial scar Mammary dysplasia
4. Galactocele Abscess
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Benign lesions of the Breast:
A.Ducts
1) Papilloma
Benign proliferation of ductal epithelium that projects into lumen of the duct& is
connected to the epithelium by a fibrovascular stalk.
Within major ducts= subareolar in location.
Usually single, when multiple they occur in peripheral ducts.
They extend longitudinally in the duct lumen.
The duct around it can dilate forming a cyst.( Origin of “intracystic papilloma”).
• Presentation: serous or bloody nipple discharge ( due to their fragile blood
supply leading to necrosis, infarction and bleeding).
• Mammogram:
- usually ∧ invisible
- rarely∧ retroareolar mass
- sometimes ∧ subareolar
2)Duct ectasia
1ry affects the major ducts in the subareolar region.
The distended ducts are filled with fluid or thick unresorbed secretions and
cellular debris.
Etiology: 2ry to periductal inflammation.
The duct may be weakened by surrounding inflammation become
patulous, filled with unresorbed debris which may calcify.
Mammogram: Tubular, serpentine structures converging to the nipple in
the subareolar region
U/S: anechoic fluid filled tubular structures.
With debris
3)Secretory deposits = Plasma cell mastitis
These appear in one of these patterns.
a) thick continuous solid, rod-shaped deposits oriented along duct lines diffusely or
segmental distribution
b) Lucent centre rod-shaped calcification
c) Lucent centered globular calcification
They are called plasma cell mastitis because of the plasma cell infiltrate that
are histologically part of the inflammatory process.
D.D. Ca calcification
4)Galactocele
Occasionally a milk containing cystic structure develops during lactation or in
the months after the cessation of nursing.
Age: 20’s-30’s
Etiology:
Obstruction of a duct .
The proximal (lobular) segment becomes distended with inspissated milk.
Clinically: it is indistinguishable from other causes of a rounded mass.
Mammogram: if the milk filled cystic mass has enough fat content ⇐ well
circumscribed radiolucent mass.
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Benign lesions of the Breast:
B.Stromal
1)Lipoma
They are generally superficial, around the periphery of breast parenchyma.
Encapsulated.
Freely movable.
Displace normal structures.
Mammogram: radiolucent, well capsulated lesion displacing the normal
breast parenchyma
U/S: hypoechoic similar in echotexture to subcutaneous fat but
distinguished from it by the capsule.
2)Fat necrosis
Etiology: a nonsuppurative inflammatory response to fat cell damage 2ry to
trauma or surgery.
Clinically: palpable (sometimes painful) mass with associated skin thickening
or retraction.
It most commonly develops unoticed by the patient.
D.D. Ca
Mammogram:
New density with spiculated outline.
Architectural distortion
Ca+ deposition
Oil cyst
3)Hamartoma = (Fibroadenolipoma)
Proliferation of fibrous and adenomatous elements in fat surrounded by a
capsule of connective tissue.
4)Radial Scar
Benign lesion.
Grossly: with a chalky appearance that is similar to cancer, and connective
tissue spicules radiating from a central nidus.
Mammogram:
Spiculated lesion
5)Abscess
Organism: staphylococcus, introduced through a skin crack around the
nipple/areola complex usually associated with breast feeding.
Mammogram: Nonspecefic
Skin thickening
U/S: hypoechoic mass with illdefined margins & internal echoes.
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Benign lesions of the Breast:
C.Lobular
1)Fibroadenoma
Most common benign solid lesion of the breast.
Age: early in life starting teenage to 30’s
Pathology: overgrowth of the specialized stromal connective tissue of the
lobule.
Pathology: overgrowth of the specialized stromal connective tissue of the
lobule.
Its enlargement causes elongation &stretching of the acini.
The acini+interlobular terminal ducts are surrounded and compressed by this
idiopathic proliferation of collagen within the lobule
Size: range from microscopic to >10cm = giant fibroadenomas.
Involution: calcification (due to hyalinization) = popcorn calcification
Mammogram: sharply circumscribed, well defined, rounded or oval smoothly
lobulated.
May be surrounded by a lucent halo = optical illusion
May have flattened contour D.D. cysts.
Calcification
Giant fibroadenoma
U/S: Ovoid= longer than deep.
Sharply defined margins.
Fairly uniform internal echoes.
2)Cysts
Age: 30-50yrs
Pathology:
as the lobular epithelium atrophies, the acini coalesce, producing fluid-filled
spaces surrounded by the sclerotic specialized connective tissue of the lobule.
some cysts are actually distended large ducts.
Mammogram:
Single or multiple
Rounded or ovoid, well defined.
Surrounding halo.
May disappear on follow up ∧ resorbed
∧ decrease in size
Eggshell-thin rim of calcification.
U/S: rounded or oval sharply defined margins.
No internal echoes.
Bright posterior acoustic enhancement.
3) Mammary Dysplasia
Definition: Benign proliferation of breast stroma.
Types:
a)cystic form: when lactiferous ducts consist of cystic dilatation of varying size.
b)Fibrous form when changes are predominantly periductal fibrosis.
c) Adenosis form: enlargement of the lobule 2ry to a benign proliferation of the
acini.
This proliferation within the TDLU is 1ry an elongation and multiplication of
the acini accompanied by an overgrowth of the epithelial &myoepithelial and
connective tissue elements in the lobule.
cystic dilatation of the acini is where Ca+ ppt. (D.D. Ca)
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Malignant Lesions of the Breast
Dr. Dorria Salem,
Professor of Radiodiagnosis,
Cairo University
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Malignant Lesions of the Breast
Malignant
Primary Secondary
Ductal Stromal Lobular
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Malignant
Primary Secondary
Ductal Stromal Lobular
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Malignant lesions: A.Ducts
1) DCIS:Poorly differentiated Comedo Ca
Definition: Comedo Ca is merely gross descriptive terminology for a duct Ca
that is characterized by abundant cells that fill the ducts of the involved lobe
with frequent areas of necrosis that often calcify.
When cut in cross-section, this necrotic debris is extruded from the duct like a
comedo.
As other ductal Ca, it may be confined to the ducts or associated with varying
degrees of invasion.
The lesion is usually detected by its classical microcalcification on
mammography.
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Malignant lesions: A.Ducts
2) Invasive Duct Ca “NOS”=Scirrhous
When a Ca does not fit into any of the defined subtypes it is termed “NOS”.
It accounts for 65% of the breast Ca diagnosed in USA.
It elicits a fairly vigorous desmoplastic response with cicatrization and
fibrosis.
This produces a very hard mass on palpation.
And a gritty texture on cut section.
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Malignant lesions: A.Ducts
4) Medullary Ca
Round or lobulated.
Relatively soft on physical examination.
Fairly movable in the breast, therefore they do not infiltrate aggressively.
They grow quite large before being detected
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Malignant lesions: A.Ducts
5) Inflammatory Ca
Clinically:
Red, hot, peau d’orange thick skin.
May respond to antibiotic therapy making the diagnosis more difficult.
Age:30yrs (usually old age)
Histologically:
Early invasion of dermal lymphatics by aggressive form of infiltrating Ca.
The underlying 1ry lesion is frequently not evident.
Poor prognosis, worse than an infiltrating duct Ca ∧ diffuse trabecular
thickening and overall increased density, that has 2ry invaded the skin.
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Malignant lesions: B.Stromal Phylloide’s tumour
This term is due to its leafy pattern of growth.
Most are benign, but about 25% will recur locally if treated incompletely&
10% metastasize.
It is classified among sarcoma as it metastasizes hematogenously to the lung
as does sarcoma and not to axillary L.N. as Ca.
Shows rapid growth over months.
Age:30-50yrs
Although sharply defined, it does not have a capsule.
It arises as does fibroadenoma, from the specialized CT of the lobule.
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Malignant lesions: B.Stromal
Phylloide’s tumour
Mammogram:
well defined, with no spiculations or microcalcifications.
Nothing could differentiate between benign and malignant forms.
U/S
Similar to fibroadenoma
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Malignant lesions:
C.Metastases
a) osteogenic sarcoma
b) Lymphoma
(i)localized (ii) diffuse (iii) 1ry
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Fundamental signs that suggest Excisional Biopsy
1)Microcalcifications:
The search for breast microcalcifications is one of the essential elements in the
interpretation of mammograms.
30% - 50% of occult Ca present by isolated microcalcifications.
2)Rounded opacities that are clinically occult:
These represent 10 to 20% of clinically occult cancers, although they are easy
to see in fatty breast, they are extremely difficult to identify in a dense,
nodular breast.
Sonography is of a great importance in the identification and characterization
of these rounded opacities.
3)Spiculated opacities that are clinically occult:
The spiculated density represents 20% to 30% of clinically occult cancers.
These lesions are highly suspicious for malignancy. Once the reality of these
images is confirmed by its presence on several projections, then excisional
biopsy must be performed.
4)Architectural Distortion:
Architectural distortion are different from microcalcifications which are
relatively easy to see and difficult to characterize.
The focal architectural distortion is difficult to identify, after eliminated
previous biopsy scarring, fat necrosis or abscesses.
The most common etiology (greater than 50%) of focal parenchymal distortion
is breast cancer.
sign %
Architectural
>50
distortion
Microcalcifications 30-50
Spiculated opacities 20-30