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Home Brief exposure to performance-enhancing drugs may be permanently remembered by muscles
Brief exposure to performance-enhancing drugs may be permanently
remembered by muscles
Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a
study published today [28 October] in The Journal of Physiology.
Previously, re-acquisition of muscle mass with or without steroid use after periods of inactivity has been attributed to
motor learning. However, this new data from the University of Oslo suggests that there is a cellular memory mechanism
within muscle of brief steroid users.
The team investigated the effects of steroids on muscle re-acquisition in mice and discovered greater muscle mass and
more myonuclei which are essential components for muscle fibre function were apparent after returning to exercise.
Professor Kristian Gundersen explains how they carried out the study and the results found:
Mice were briefly exposed to steroids which resulted in increased muscle mass and number of cell nuclei in the muscle
fibres. Three months after withdrawal of the drug (approximately 15% of a mouse's life span) their muscles grew by 30%
over six days following load exercise. The untreated mice grew insignificantly.
The findings might have consequences for the exclusion time of doping offenders as brief exposure to anabolic steroids
might have long lasting performance-enhancing effects.
Prof Gundersen says:
The results in our mice may correspond to the effects of steroids lasting for decades in humans given the same cellular
muscle memory mechanism. The new results might spur a debate on the current World Anti-Doping Agency (WADA)
code in which the maximum exclusion time is currently two years.
Additionally, the data suggests that strength training when young might be beneficial later in life since the ability to
generate new myonuclei is impaired in the elderly.
Future studies should include human muscles and further investigation into the cellular and molecular mechanism for
muscle memory.
Microscopy images showing cross sections of muscle fibers with (right) and whiteout (lest) anabolic steroids.
Credit: Jo C Bruusgaard
ENDS
Notes to Editors
1. Full paper (please contact Lucy Holmes for the manuscript):
Ingrid M. Egner, Jo C Bruusgaard, Einar Eftestl & Kristian Gundersen (2013) A cellular memory mechanism aids overload
hypertrophy in muscle long after an episodic exposure to anabolic steroids. The Journal of Physiology.
2. Media resources, including photos and quotes, are available freely at
www.mn.uio.no/ibv/english/research/groups/physiology/labgrupper/gundersen/for-media
3. The Journal of Physiology publishes advances in physiology which increase our understanding of how our bodies
function in health and disease. http://.jp.physoc.org

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Performance-enhancing drugs may be permanently remembered by muscles | Physiological Society 4/8/2014
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Contacts
Lead author
Prof Kristian Gundersen, University of Oslo; kristian.gundersen@ibv.uio.no, +47 22 85 46 17 (work), +47 92 69 02 20
(mob)
The Journal of Physiology
Lucy Holmes, Media and Communications Officer, LHolmes@physoc.org, +44 (0)20 7269 5727
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Performance-enhancing drugs may be permanently remembered by muscles | Physiological Society 4/8/2014
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