Cardiovascular System Test 2005

PharmacyPrep.
Com Cardiovascular Test

CARDIOVASCULAR SYSTEM TEST

1-Diuretic characterized for hormonal side effects and the decrease of Na, increase
potassium and uric acid levels
a) Acetozalamide
b) Spirolactone
c) Hydroclorotiazide
d) Furosemide
e) Triametrene

2- Antithrombolitic agents are contra indicated in
I-Myocardial Infarction
II-Hypertensive patients
III-Bleeding from the GIT
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct

3- Patient with renal failure and normal liver function is showing sensibility to the drug,
this means that
a) High accumulation of metabolite
b) High concentration of drug protein binding
c) High volume of distribution
d) High concentration of drug in the systemic circulation
e) High accumulation of drugs into tissues

4- Normal osmotic blood pressure in a health adult:
a) 280mOsm/L
b) 280Osm/L
c) 280mOsm/ml
d) 280Osm/ml
e) 280mOsm/100ml

5-Which increase water permeability at collecting tubules?
a) ADH
b) Hydroclorothiazide
c) Aldosterone
d) Triametrene
e) Spirolactone

6- Digoxin is cardiac digitalis widely used in CV disorders, which toxicity is increased by
I- Erythromycin
II- Quinidine
Copyright 2001-2005 TIPS Inc. Unauthorized reproduction of this manual is prohibited. This
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1
PharmacyPrep.Com Cardiovascular Test
III- Cholesteramine
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct

7- Acetozalamide, a carbonic anhydrase diuretic and hydroclorothiazide, a thiazide
diuretic have an identical molecular group very important in their structure knows as:
a) Sulfonamide group
b) Pyrimidine group
c) Purine group
d) Pyrrolidine group
e) Ether group

8- Which of the following causes hyperchloremic and systemic acidosis;
A-acetazolamide
B-aldactone
C-Furosemide
D-Lasix
E-None of the above

9- What happens in metabolic alkalosis:
A-Increase HCl
B-Increase NaOH
C-Increase NaHCO
3

D-Increase NH
3

E-None of the above

10-During absolute refractory period the myocardial fiber:
a) Receive the strongest stimulation
b) It is relaxed but is able to respond to any stimulus
c) Respond to the most sensible stimulus
d) Do not respond to any stimulus
e) None of the above

11- Abnormal persistent dilatation of blood vessels is known as:
a) Embolism
b) Aneurism
c) Emphysema
d) Starvation
e) Atheroschlerosis

2
12-Which of the following drug has renal artery stenosis and therefore not safe in renal
disorder patients.
A-Propranalol
B-Hydralazine
C-Captopril
D-Warfarin
E-Heparin

13- Which of the following statements regarding HEPARIN is/are right
I- It is a mucopolysacaride (heteropolysaccharide), organic acid present naturally in many
tissues especially in lungs and liver.
II- It has anticoagulant proprieties that inhibit the conversion of prothrombim to thrombin
and fibrinogen to fibrin
III- It has antithrombin III as it co-factor
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct

14- Heparin and warfarin are very popular anticoagulant agents. What is wrong regarding
heparin and warfarin?
a) Both have anticoagulant proprieties
b) Warfarin has activity only in vivo
c) Heparin has activity only in vivo
d) Heparin has activity in vivo and in vitro
e) All are correct

15- Which of the following calcium channel blockers cause bradicardia
I- Nifedipine
II- Verapamil
III- Diltiazen
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct

16- All are drugs that decrease LDL- Low Density Lipoproteins, EXCEPT:
a) Colfibrate
b) Genfibrozil
c) Cimetidine
d) Sinvastatin
e) Pravastatin

3
CARDIOVASCULAR SYSTEM TEST ANSWERS

1-Diuretic characterized for hormonal side effects and the
decrease of Na, increase potassium and uric acid levels
a) Acetozalamide
b) Spirolactone
c) Hydroclorotiazide
d) Furosemide
e) Triametrene
Ans-B
Comments: spiranolactone is aldosterone antagonist and
has hormonal side effects. side effects gynacomastia,
irregular mensturation, hyperkalemia

2- Antithrombolitic agents are contra indicated in
I-Myocardial Infarction
II-Hypertensive patients
III-Bleeding from the GIT
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct
Ans-B
Comments:thrombolytics and antithrombotics are
contraindicated in bleeding disorders: warfarin, aspirin,
clopidogrel, ticlopidine. Monitoring is essential.

4

3- Patient with renal failure and normal liver function is
showing sensibility to the drug, this means that
a) High accumulation of metabolite
b) High concentration of drug protein binding
c) High volume of distribution
d) High concentration of drug in the systemic circulation
e) High accumulation of drugs into tissues
3-A
Comments: at normal liver function patient shows
sensitivity when high accumulation of metabolites in liver.

4- Normal osmotic blood pressure in a health adult:
a) 280mOsm/L
b) 280Osm/L
c) 280mOsm/ml
d) 280Osm/ml
e) 280mOsm/100ml
4-A

5-Which increase water permeability at collecting tubules?
a) ADH
b) Hydroclorothiazide
c) Aldosterone
d) Triametrene
e) Spirolactone
5-A
Comments: anti-diuretics hormones (ADH) increase water
permeability at collecting tubule. Derivatives of ADH such
desmopressin is used enuresis.

5

6- Digoxin is cardiac digitalis widely used in CV disorders,
which toxicity is increased by
I- Erythromycin
II- Quinidine
III- Cholesteramine
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct
6-C
Comments: erythromycin, tetracyclin and quinidine,
corticosteroid increases cardiovascular toxicities of
digoxin.
Digoxin toxicity (digitalis toxicity, cardiotoxicity)cuases
with hypokalimic drugs (such as all diuretics except,
potassium sparing diuretics)

7- Acetozalamide, a carbonic anhydrase diuretic and
hydroclorothiazide, a thiazide diuretic have an identical
molecular group very important in their structure knows as:
a) Sulfonamide group
b) Pyrimidine group
c) Purine group
d) Pyrrolidine group
e) Ether group
7-A
Comments: thiazides, loop and carbo
6
Comments: sulfonamide groups in present in CA inhibitors,
thiazides, loop diuretics(except: ethacrinic acid),, therefore
these drugs may cause sulfa allergy and should be avoided
in patients with sulfa allergy.

SO
2
NH
2
is present in
sulfonamide,
Celecoxib
TMP/SMX (Co-trimoxazole)
Sulfonyl ureas
Diuretics

8- Which of the following causes hyperchloremic and
systemic acidosis;
A-acetazolamide
B-aldactone
C-Furosemide
D-Lasix
E-None of the above
8-A
Comments: CA inhibitors exhibit hyperchloremic and
systemic acidosis.
Metabolic acidosisCA inhibitors, Potassium sparing,
Metabolic alkalosisLoop diuretics, thiazides

7
9- What happens in metabolic alkalosis:
A-Increase HCl
B-Increase NaOH
C-Increase NaHCO
3

D-Increase NH
3

E-None of the above
9-C
Comments: Serum HCO
3
-
levels increase in metabolic
alkalosis And CO
2
decrease.

10-During absolute refractory period the myocardial fiber:
a) Receive the strongest stimulation
b) It is relaxed but is able to respond to any stimulus
c) Respond to the most sensible stimulus
d) Do not respond to any stimulus
e) None of the above
10-D

CPR page 739, 5
th
Ed.
Comments: during absolute refractory period the
myocardial fibers do not respond to stimulus.

The cell cannot respond to any stimuli during the absolute
refractory period (beginning during phase 1 and ending at
the start of phase 3)

A cell ability to respond to stimuli increases as
repolarization continues. During relative refractory period,
which occurs during phase 3 , the cell can respond to a
strong stimuli.
8

11- Abnormal persistent dilatation of blood vessels is
known as:
a) Embolism
b) Aneurism
c) Emphysema
d) Starvation
e) Atheroschlerosis
11-B
Comments: abnormal dilatation of blood vessels leads to
aneurism.
Embolism: causes by accumulation of fragments generated
from thrombus.
Emphesema: permanent dilatation of alveololars in lungs.
Atherosclerosis: accumulation of lipids in blood vessels.

12-Which of the following drug has bilateral renal artery
stenosis and therefore not safe in renal disorder patients.
A-Propranalol
B-Hydralazine
C-Captopril
D-Warfarin
E-Heparin
12-C
Comments: ACE inhibitors such as captopril and all ACE
and ARB have stenosis and therefore not safe in renal
disorder patients.

9
13- Which of the following statements regarding
HEPARIN is/are right
I- It is a mucopolysacaride (heteropolysaccharide), organic
acid present naturally in many tissues especially in lungs
and liver.
II- It has anticoagulant proprieties that inhibit the
conversion of prothrombim to thrombin and fibrinogen to
fibrin
III- It has antithrombin III as it co-factor
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct
13-E
Comments: all of the above are correct about heparins.

14- Heparin and warfarin are very popular anticoagulant
agents. What is wrong regarding heparin and warfarin?
a) Both have anticoagulant proprieties
b) Warfarin has activity only in vivo
c) Heparin has activity only in vivo
d) Heparin has activity in vivo and in vitro
e) All are correct
14-C
comments: heparins have activity in vivo and in vitro.

10
15- Which of the following calcium channel blockers cause
bradycardia
I- Nifedipine
II- Verapamil
III- Diltiazen
a) I only
b) III only
c) I and II only
d) II and III only
e) All are correct
15-D
comments: varapamil and diltiazem may cause bradycardia
and therefore they are not used together with -blockers

16- All are drugs that decrease LDL- Low Density
Lipoproteins, EXCEPT:
a) Colfibrate
b) Genfibrozil
c) Cimetidine
d) Sinvastatin
e) Pravastatin
16-C
Comments: cimetidine is not a antihyperlipidemic class of
medication
11
12

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Com Cardiovascular Test

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