Professional Documents
Culture Documents
Definition:
Immunity constitutes all the physiological mechanism which allow the
body to recognized materials as foreign to itself and to neutralize or
eliminate them.
Function:
1. Protection against microbes, viruses, bacteria, and other unicellular
and multicellular organism.
2. Elimination of worn out or damage body cells.
3. Immune surveillance (cancer)
4. Seems to be involved in the process of aging.
5. Major obstacle to successful transplantation of organs.
Classification:
A. Non-specific defense mechanism
Example are:
1. phagocytes
2. lysozymes
3. basic polypeptides
4. properdin
5. interferons
2. Hapten - any incomplete antigen, ex. Any substance not of itself capable
of provoking an immune response but able to serve as a partial
antigen when bound to another substance. Haptens are usually
of low molecular weight and may be of relatively simple
structure.
B-cells:
- confer specific immune resistance against bacteria
T-cells:
- Major carriers of specific immunity against fungi, viruses, parasites
and few bacteria which to survive must live inside cells.
- Destruction of cancer cells.
- Rejection of solid-tissue transplant.
Function of Antibodies:
1. Neutralization of antigens
2. Antigen – antibody precipitation
3. Agglutination of bacteria
4. Lysis of cellular structure
5. Opsonization
IgD – present in the blood in very small amounts and its function is as yet
unknown
COMPLEMENT:
Complement a component of blood serum, consists of a set of several
proteins. They are inactive enzymes that are activated in a definite sequence
to catalyze an intricately linked series of reactions. The end result of this
rapid-fire activity is to produce cytolysis.
PROPERDIN:
Like complement, properdin consists of a set of proteins present in
blood serum as inactive enzymes. When activated it can initiate the
complement series in addition to the usual antibody method of activating it.
INTERFERON:
It is another protein compound that plays a part in producing
immunity. It is synthesized by body cells under certain conditions, notably
after viruses have invaded them. Released from the cells that produce it,
interferon acts on other body cells to defend them against viruses. Recent
evidence suggests that interferon retards the growth of cancer cells.
Clinical Correlation:
A. Autoimmunity
- Myasthenia Gravis
- Rheumatic Heart Diseases
- Acute Glomerulonephritis
- SLE
- Thyroiditis
3. Agammaglobulinemia
- B cells fail to develop
- susceptible to bacterial infections.