5/28/2014 248th ACS National Meeting, San Francisco, CA

http://abstracts.acs.org/chem/248nm/index.php 1/2
248thACSNationalMeeting,SanFrancisco,CA
DocumentID:15729
ProgramArea:PMSE:DivisionofPolymericMaterialsScienceandEngineering
SymposiumTitle:(PMSE0011G)PorousPolymers
INSTITUTIONS
1.UniversityofManchester,SchoolofMaterials,Manchester,M139PL,UnitedKingdom
2.FederalUniversityofParaiba,DepartamentodeEngenhariadeMateriais,JoaoPessoa,Paraiba,Brazil
3.FederalUniversityofParaiba,DepartamentodeCienciasFarmaceuticas,JoaoPessoa,Paraiba,Brazil
4.McGillUniversity,MaterialsEngineering,Montreal,Quebec,H3A0C5,Canada
AUTHORS
1.JonnyJBlaker
1
,PhD,UniversityofManchester,SchoolofMaterials,OxfordRoad,Manchester,Manchester,
M139PL,UnitedKingdom,441613063587,UnitedKingdom,jonny.blaker@manchester.ac.uk
2.EudesLeonnan
2
,
3.AnaLeticiaBraz
3
,
4.IsaqueJeronimo
2
,
5.ShowanNNazhat
4
,
6.ElitonSMedeiros
2
,
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5/28/2014 248th ACS National Meeting, San Francisco, CA
http://abstracts.acs.org/chem/248nm/index.php 2/2
CountryofBirthUnitedKingdom
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Title:Highlyporousnanofibresandtheirformationintomacroporousstructuresbysolutionblowspinning:
Applicationsintissueregeneration
AbstractBody:Wehavedevelopedanewtechniquetorapidlyproduceporousnanofibresandformtheminto
macroporousconstructswithapplicationsdirectedtotissueregeneration.Thecombinatorialtechniqueisbasedon
solutionblowspinning(SBS)andthermallyinducedphaseseparation(TIPS).SBScanproducenanofibres,
analagoustothoseelectrospunfrompolymersdissolvedinsuitablesolvents,yetwithaproductionrate(perhead)
100timesfaster,andwithouttheneedforelectricfields.Inthisworkwefreezethenanofibresshortlyaftertheir
formation,aheadofexcessivesolventevaporation,causingthesolventtofreezeandhencephaseseparation.
Subsequentfreezedryingofthefibresremovesthesolvent,yieldingthehighlyporousnanofibresshowninFigure
1.
Polylactidewasdissolvedinsuitablesolventsatvaryingconcentrationsfrom20w/v%(polymermasstosolvent
volume)to1w/v%andinjectedintotheSBSheadatratesof100200mlmin
1
,theairpressureappliedtothe
SBSheadwasbetween1060PSi.WefurthercombinedthenewSBSTIPStechniquewithinsituporosifiersof
controlledsize(100mmupto2mm)andsucceededinproducingintegralmacroporousscaffolds(oftheseporous
nanofibres)withinterconnectedpores(thevolumeoftheseporosifiersconstituted6080%ofthetotalvolume).
Porositiesofthesefoamsare>98%.Thesehighsurfacearea/highporositymaterialshaveapplicationsin
regenerativemedicine,tissueengineering,separationsandascatalystsupports.