PharmacyPrep.

Com Drug Interactions

Copyright 2000-2010 TIPS Inc. Unauthorized reproduction of this manual is prohibited. This
manual is being used during review sessions conducted by PharmacyPrep.
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PHARMACY PREP

DRUG & DRUG INTERACTIONS

1-A 55 year old male patient receiving warfarin for deep vein thrombosis, he get the
prescription of carbamazepine; which of the following drug interaction possible:
I-Carbamazepine decrease metabolism of warfarin
II-Carbamazepine is has not interaction with warfarin
III-Carbamazepine increase metabolism of warfarin
A-I only
B-III only
C-I and II only
D-II and III only
E-All of the above
Ans-B
Tips: Carbamazepine is an inducer of CYP 2C9, and the same enzyme is substrate of
warfarin. Therefore Carbamazepine increase metabolism of warfarin

2-A 20 year old female patient currently on fluoxetine for depressive disorder, she get the
prescription of Tylenol # 3 for sever headache. Which of the following drug interaction
are possible:
A-Fluoxetine metabolism increases
B-Codeine metabolism increases
C-Fluoxetine metabolism decrease
D-Codeine metabolism decrease
E-No change and there is no drug interactions
Ans-D
Tips: Fluoxetine inhibits CYP 2D6 and this same enzyme is a substrate for codeine and
therefore decrease codeine metabolism

3-A 40-year old female is regular customer of your pharmacy, her current medical history
include lovastatin. She brings prescription for her recent condition, Which of the
following medication is safe for her medical profile:
A-Erythromycin
B-Ketoconazole
C-Grapefruit juice
D-Niacin
E-Hydrochlorothiazide
PharmacyPrep.Com Drug Interactions
Copyright 2000-2010 TIPS Inc. Unauthorized reproduction of this manual is prohibited. This
manual is being used during review sessions conducted by PharmacyPrep.
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4- Enzyme complex not working as a drug-metabolizing enzyme may include:
a) Cytocrome P-450
b) Cytocrome P450 3A4
c) Alcohol Dehidrogenase
d) UDP Glucoronyl Transferase
e) Cytocrome oxidase.
Ans-C

5-What is incorrect about tetracycline antibiotics:
I-Take with water and milk
II-Take with food
III- Must take empty stomach
A-I only
B-III only
C-I and II only
D-II and III only
E-All of the above
Ans-C

6-Tetracyclin binds with?
A-monvalent ions
B-bi valent ions
C-tri valent ions
D-b and C only
E-all of the above
Ans-D

7-Ciprofloxacin should be taken with:
A-avoid taking with full glass of milk
B-take with or after food
C-take empty stomach
D-take with or without food
E-A and D
Ans-E

8-A patient using calcium supplements 500 mg bid. Now gets the prescription of
ciprofloxacin 500 mg bid for 3 days.
What is appropriate method of administration?
A-Take ca supplements and ciprofloxacin together morning and evening.
B-Take calcium supplements before 2 hour and after 4 hours of ciprofloxacin.
C-Stop taking calcium supplements for 3 days and continue ciprofloxacin
D-stop taking ciprofloxacin and continue calcium supplement daily
E-Call the doctor, change to tetracyclin
Ans-C

PharmacyPrep.Com Drug Interactions
Copyright 2000-2010 TIPS Inc. Unauthorized reproduction of this manual is prohibited. This
manual is being used during review sessions conducted by PharmacyPrep.
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9-Which of the following statement is incorrect about alcohol and drug interactions?
A-Alcohol and Metronidazole can give disulfiram reactions
B-Alcohol and metformin can give lactic acidosis
C-alcohol and chlorpropamide an antidiabetic drug can give lactic acidosis
D-alcohol and benzodiazepine can give sedation
Ans-C

10-All of the following agent can cause urine discoloration, EXCEPT;
A-Metronidazole
B-Rifampin
C-Sulfasalazine
D-pyrivinium pamoate
E-tetracycline
Ans-E

11-Which pharmacodynamics property can be used to effectively prevent the alcohol
withdrawal symptom of tachycardia?
A. 1 antagomists
B. 1 agonists
C. 1 antagonists
D. 1 agonists

Answer: C The tachycardia that occurs with alcohol withdrawal is caused by an
increase in sympathetic stimulation. Because 1 receptors in the heart respond to
sympathetic stimulation by increasing heart rate, any medication that blocks 1
stimulation will help to prevent tachycardia.