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U

UCB Pharma SA Chemin du Foriest B 1420 Braine lAlleud (Belgium)


TOQ /BPS/ ITD Innovation Technology Development
Tel: +32 2 386 2203 Fax: +32 2 386 3843 GSM : +32 499 549 471
edith.norran@UCB.com

E-mail:

Subject : List of proposal for an internship at UCB PHARMA for


2015 (Belgium, UK )
By E NORRANT

Please find the list of subjects for internship at UCB Pharma for 2015 on the:
o 2 research centers based

Braine lAlleud in Belgium close to Brussels

Slough in UK close to London


o manufacturing plants

Braine lAlleud in Belgium

On Braine LAlleud close to Brussels, we have 27 proposals


a. 2 subjects on Knowledge management
b. 1 subject on Communication
c. 1 subject in Data analysis from Patient Department
d. 5 subjects in Cell Culture Process Development (CCPD)
e. 1 subject in Biological formulation Development
f. 1 subject in Biological Development Analytical (ADB)
g. 9 subjects in Chemical formulation Development (CPhD)
h. 1 subject in Packakging Department
i. 2 subjects in Braine manufacturing plant
j. 4 subjects in continuous chemical process in Innovation Department

On Slough site close to London , we have 3 proposals


a. 3 subjects in Analytical Development Biological Department (ADB)

On both research centers, we have more than 40 different nationalities, so English language is
recommended for reports and oral communication.
If you are interested by one of this proposal, please send your resume and a motivated letter to the
following email address: edith.norrant@ucb.com and the manager of the subject ( See on the proposal).
You will receive an indemnity during your internship in order to reimburse your accommodation
and meals.
If you need any information, do not hesitate to contact me
Contact :
EDITH LECOMTE-NORRANT
GPS/ ITS Innovation & Technology & Sciences Director
UCB Pharma Avenue de l'Industrie B 1420 Braine l'Alleud (Belgium)

Tel +32 (0) 2 386 22 03


Mobile: +32(0)499 54 94 71
E-mail : edith.norrant@ucb.com

UCB Pharma Tel : (322) 386 21 11 Fax : (322) 384 55 29 www.ucb.com


Headquarters : Alle de la Recherche, 60 B-1070 Brussels (Belgium)

INTERNSHIP FOR 2015

Website http://www.ucb.com/
UCB Pharma :
A global biopharma focused on severe diseases with operations in approximately 40 countries
and global revenue of 3.4 billion in 2012.

We combine biology and chemistry to make major breakthroughs. By integrating our


expertise in large, antibody-based molecules and small, chemically-derived molecules, we can offer
families with severe diseases and their specialist physicians the advantages of both large and small
molecules to produce extraordinary breakthroughs.
We partner with the leaders in the pharmaceutical industry. The complexities of severe
diseases are beyond the expertise and resources of a single organisation. That is why we have
teamed up with partners - we play to our strengths and tap into the organisations with greater or
complementary strengths

INTERNSHIP FOR 2015

Content :
N1 : Master en communication............................................................................................ 4
N2 : Data analysis from patients, doctors,.......................................................................5
N 3 : Quantitative mass spectroscopy for process understanding.......................................6
N 4 : Aggregate analysis in biopharmaceutical molecules...................................................7
N 5 : Higher order analysis in biopharmaceutical molecules...............................................8
N6 : Internship Metabolic understanding and modeling.......................................................9
N7 : Internship Microscale Bioreactor Development In Cell culture....................................10
N8 : Intern in protein purification miniaturization and metabolite assays development and
automation In Cell culture.................................................................................................... 11
N9 : Intern Scale-up / Scale-down of Upstream Process.....................................................12
N10 : Internship Cell Culture Process Development...........................................................13
N 11 TechOps Data sciences............................................................................................... 14
N 12 TechOps Data sciences............................................................................................... 15
N 13 Investigations into Donnan effect............................................................................. 16
N 14 Evaluation of assay ruggedness of a relative potency Binding ELISA used to assess
the activity of antibody-based drugs.................................................................................... 17
N 15 Primary Packaging Components Optimization for Freeze-Dried Products...................18
N 16 Review of cleaning monitoring and cleaning validation strategy to a multi-product
GMP pilot plant..................................................................................................................... 19
N 17 Assessment of spray-drying technology in the formulation strategy of poorly soluble
compounds - case study...................................................................................................... 20
N 18 Assessment of continuous granulation process in the early stage formulation strategy
- case study.......................................................................................................................... 21
N 19 Development of a dissolution test for poorly water-soluble compounds....................22
N 20 Assessment of the adsorption, solubility and stability of poorly soluble compounds to
support hERG and Purkinje studies...................................................................................... 23
N 21 Feasibility of suspension formulations according to particle size distribution............24
N 22 Assessment of the absorption variability of one drug under development according to
animal species..................................................................................................................... 25
N 23 Development of dry powder nanoparticles processes................................................26
N 24 Nanostructured Lipid Carrier formulations for brain delivery of poorly compounds...27
N 25 Manufacturing plants................................................................................................ 28
N 26 MeOH/NH3 Distillation optimization...........................................................................29
N 27 Continuous Chemical process: step 2: chemical reaction..........................................30
N 28 Continuous Chemical process: step 3 chemical reaction...........................................31
N 29 Continuous Chemical process: step 5 Crystallization.................................................32
N 30 Continuous Chemical process: step 4 separation.......................................................33

INTERNSHIP FOR 2015

INTERNSHIP FOR 2015

N1 : Master en communication
(Braine LAlleud /Belgique)
Description du profil recherch :
Nous recherchons un stagiaire H/F, Master en Communication ou IT , ayant une bonne
connaissance du web, de la stratgie de communication ainsi que du logiciel SharePoint 2010. La
connaissance de langlais crit et parl est galement un atout. Vous tes rigoureux et autonome,
diplomate et organis.
Convention de stage:
Minimum 6 mois temps plein
Indemnit de stage 750/mois
Lieu de travail : Site UCB Braine-lAlleud, Avenue de lIndustrie
1420 Braine-lAlleud (Belgium)
Tel.: +32 2 386 40 40
Date de prise de fonction :
partir du mois de fvrier/mars 2015 Juillet/ Aout 2015
Ou Juillet/ aout 2015 Dec 2015
Descriptif du poste : Stage en collaboration avec notre dpartement en prenant en charge les
missions suivantes :
Mission n1
Restructurer et rorganiser plusieurs sites Intranet afin damliorer la visibilit de nos
dpartements en interne.
Loutil utilis UCB est SharePoint 2010.
Mission n2
Participer lanimation et la mise jour de ces sites intranet : gestion de contenus,
prsentation des dpartements, Events, News, Liens, photos, FAQ,
Contribuer la cration, production et fabrication de supports de promotion usage interne
tels Newsletter, spot TV, social media...
Mission n3
Participer la rdaction dune gouvernance dcrivant les rles et responsabilits de chacun
Dvelopper un Network permettant la capture des informations provenant tant du
management que de l
Identification et mise en place dindicateurs de performances mesurant le dploiement de
lintranet.
Tuteur du stage et contact:
Philippe Van Larebeke
Biopharma Process Science - Knowledge Management Specialist
UCB Pharma - B - 1420 Braine l'Alleud, Belgium,
Bat T1 - Office 0.152 Tel: +32-2-386.28.58 Mob: +32-494-578.235

philippe.vanlarebeke@ucb.com

INTERNSHIP FOR 2015

N2 : Data analysis from patients, doctors,


(Braine LAlleud /Belgique)
Description of the work :
Nous recherchons un stagiaire H/F, en analyse de base de donnes US .
Lobjective est de traiter des donnes issues du site Web UCB patient centricity US,.afin de
les regrouper par thmes et dfinir les actions appropries.
Ces donnes proviennent de patients, de mdecins,
Un bon niveau danglais est indispensable.
Convention de stage:
Minimum 6 mois temps plein
Indemnit de stage : oui
Lieu de travail : Site UCB Braine-lAlleud, Avenue de lIndustrie
1420 Braine-lAlleud (Belgium)
Tel.: +32 2 386 40 40
Date de prise de fonction :
partir du mois de fvrier/mars 2015 Juillet/ Aout/sept 2015
Ou Juillet/ aout 2015 to Dec 2015
Tuteur du stage et contact:
Katia Baeke
Tech Ops Patient Champion
Established Brands & Solutions & Supply
Tel +32-238-62256
Katia.Baeke@ucb.com

INTERNSHIP FOR 2015

N 3 : Quantitative mass spectroscopy for process


understanding
(Slough / UK)
Job description
We will use mass spectrometry to understand protein modifications in a representative clinical
development process. Isotopic labeling studies will allow quantitative analysis of post-translational
modifications. The skills that will be learned included cell culture, protein expression, protein
purification and protein analysis
Work closely with NewMedicines cell culture team
Contract:
Minimum 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Celltech, branch of UCB Pharma S.A.
208 Bath Road, Slough, Berkshire, SL1 3WE, UK - Slough, Berkshire
Tel: +44 1 753 534 655
E-mail: info-uk@ucb.com
Started date :
Best date: ASAP : Q1 2015 for 6 months
Profil of student
A training in bioprocess and/ or in Analytical development
Manager of the student:
Name John OHara
e-mail : john.ohara@ucb.com
phone number : +44-1753-44 7987
Head of department : Tops/BTS/ASB :Director Characterisation,
his work will be confidential
Fieds concerned:
Bioanalysis / Biochemistry

INTERNSHIP FOR 2015

N 4 : Aggregate analysis in biopharmaceutical


molecules
(Slough / UK)
Job description
Aggregates are commonly associated with immunogenicity and are considered critical quality
attributes for protein biopharmaceuticals. Consequently many methods have been developed to measure
aggregate levels. However, the relationship between these methods are currently not well understood.
This project will evaluate a range of development molecule types (IgG 1 and 2, bispecifcs and multimers)
using a range of techniques that UCB has recently invested in eg A4F, SEC MALLS, DLS and AUC.
Work closely with NewMedicines cell culture team
Contract:
Minimum 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Celltech, branch of UCB Pharma S.A.
208 Bath Road, Slough, Berkshire, SL1 3WE, UK - Slough, Berkshire
Tel: +44 1 753 534 655
E-mail: info-uk@ucb.com
Started date :
Best date: ASAP : Q1 2015 for 6 months
Profil of student
A training in bioprocess and/ or in Analytical development
Manager of the student:
Name John OHara
e-mail : john.ohara@ucb.com
phone number : +44-1753-44 7987
Head of department : Tops/BTS/ASB :Director Characterisation,
his work will be confidential
Fieds concerned:
Bioanalysis / Biochemistry

INTERNSHIP FOR 2015

N 5 : Higher order analysis in biopharmaceutical


molecules
(Slough / UK)
Job description
Molecular structures are critical to the function of the molecule in vivo. Although several methods
are available to monitor higher order structure are currently not well understood. This project will
evaluate a range of development molecule types (IgG 1 and 2, bispecifc and multimers) using a range of
techniques that UCB has recently invested in eg Circular Dichroism, FTIR and Raman. The project will
incorporate a statistical package to determine the best practice for measuring protein samples and
providing data in a meaningful and consistent manner.
Work closely with NewMedicines cell culture team
Contract:
Minimum 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Celltech, branch of UCB Pharma S.A.
208 Bath Road, Slough, Berkshire, SL1 3WE, UK - Slough, Berkshire
Tel: +44 1 753 534 655
E-mail: info-uk@ucb.com
Started date :
Best date: ASAP : Q1 2015 for 6 months
Profil of student
A training in bioprocess and/ or in Analytical development with some knowledge in statistic

Manager of the student:


Name John OHara
e-mail : john.ohara@ucb.com
phone number : +44-1753-44 7987
Head of department : Tops/BTS/ASB :Director Characterisation,
his work will be confidential
Fieds concerned:
Bioanalysis / Biochemistry

INTERNSHIP FOR 2015

N6 : Internship Metabolic understanding and


modeling
Dept :Cell Culture Process Development Group (Braine LAlleud /Belgium)
Job description
As metabolic understanding and modeling intern, you will evaluate the impact and criticality of a
subset of cell culture process parameters in cell metabolism during a fed-batch production process. You
will conduct laboratories cell culture experiments to investigate the impact of operating process
parameters and cell culture media and feed on the cell metabolism and growth as well as on productivity.
You also will apply statistical methods, perform extended design of experiment (DoE) and analysis of
experiments to determine the relationship between the studied process parameters. In parallel you will
develop metabolic models to support cell culture development and will be in close interaction with the
cell culture process development group.
Profile
Candidates applying to this internship should bring fresh ideas, unique perspectives, and
fundamental knowledge. They should be passionate about science and engineering and their application
to biotechnology. They should thrive on the challenges associated with complex solving and working
with an international team. Candidates must be highly self-motivated and willing to work independently
while communicating results, progress and questions in a timely manner. You will use a set of a different
tools starting from the use of statistical software to generate DoE and optimize the cell culture production
to the analysis of metabolites using a state of the art analytical platform.
Mission
The candidates should:
Study and excel in one the following preferred fields: biology, chemistry or other related science
fields, as well as chemical and biomedical engineering.
Have outstanding analytical ability and communication skills.
Experience working in research labs or industry and experience with animal cell culture are highly
desirable.
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015
Manager with email and phone number:
Ben Yahia Bassem
PhD Student : Upstream Process Sciences

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INTERNSHIP FOR 2015


Tel : +32-2-386 7859

bassem.benyahia@ucb.com

N7 : Internship Microscale Bioreactor Development


In Cell culture
Dept :Cell Culture Process Development Group (Braine LAlleud /Belgium)
Job description
As Microscale Bioreactor Development intern, you will participate in setting-up the Ambr microscale
bioreactor system in house. You will perform expended design of experiment (DOE) studies in the
ambrTM microscale bioreactor system in parallel with the same DOE study but reduced in 2L scale
bioreactors. You will assess the differences between microscale and 2L scale bioreactors and evaluate
whether or not the trend identified in microscale bioreactors can be reproduced at 2L scale.You will
conduct laboratories cell culture experiments to investigate the impact of operating process parameters on
cells growth and productivity as well as on the quality of a model recombinant protein.
.
Profile
As Microscale Bioreactor Development intern, you will participate in setting-up the Ambr microscale
bioreactor system in house. You will perform expended design of experiment (DOE) studies in the
ambrTM microscale bioreactor system in parallel with the same DOE study but reduced in 2L scale
bioreactors. You will assess the differences between microscale and 2L scale bioreactors and evaluate
whether or not the trend identified in microscale bioreactors can be reproduced at 2L scale.You will
conduct laboratories cell culture experiments to investigate the impact of operating process parameters on
cells growth and productivity as well as on the quality of a model recombinant protein.

Mission
The candidates should:
Study and excel in one the following preferred fields: biology, chemistry or other related science
fields, as well as chemical and biomedical engineering.
Have outstanding analytical ability and communication skills.
Experience working in research labs or industry and experience with animal cell culture are highly
desirable

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015
Manager with email and phone number for contact:
Kochanowski Nadine
Group Leader Upstream Process Sciences
USP Development 2
TE : +32-2-386 1848
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INTERNSHIP FOR 2015

Nadine.Kochanowski@ucb.com

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INTERNSHIP FOR 2015

N8 : Intern in protein purification miniaturization


and metabolite assays development and automation In
Cell culture
Dept :Cell Culture Process Development Group (Braine LAlleud /Belgium)
Job description
As an intern you will contribute to develop and implement high throughput protein purification methods
to support the cell culture process development team on a fully automated platform. You will use a set a
different tools starting from the use of statistical software to generate DoE and optmize the purification to
the analysis of the product quality attribute using a state of the art analytical platform. You will asses the
comparability of developped HTR methods to the existing ones. In parallel youll develop in process
metabolites assays to support cell culture development and will be in close interaction with the cell
culture process development group.
Profile
Candidates applying to this internship should bring fresh ideas, unique perspectives, and
fundamental knowledge. They should be passionate about science and engineering and their application
to biotechnology. They should thrive on the challenges associated with complex problem solving and
working with an international team. Candidates must be highly self-motivated and willing to work
independently while communicating results, progress and questions in a timely manner.
Mission
The candidates should:
Study and excel in one the following preferred fields: biology, (bio)chemistry or other related
science fields, as well as chemical and biomedical engineering . Interest in automation and in
analytical sciences is a asset for the position
Experience working in research labs or industry and basic knowledge of protein purification
and/or chromatography is a must.
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015
Manager with email and phone number for contact:
Mathy Gregory
Senior Scientist Upstream Process Sciences
Tel : +32-2-386 1876
Gregory.MATHY@ucb.com

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INTERNSHIP FOR 2015

N9 : Intern Scale-up / Scale-down of Upstream


Process
Dept :Cell Culture Process Development Group (Braine LAlleud /Belgium)
Job description
As USP Scale-up / Scale-down intern, you will contribute to the production of drug substance for
toxicology studies, at 80L scale. You will assess the differences between 2L/10L laboratory scale and
80L/2000L manufacturing scale systems and elaborate scale-up / scale-down strategies for cell culture
and primary recovery processes (centrifugation and filtration). You will conduct cell culture experiments
to investigate the impact of operating process parameters on cell growth and productivity, as well as on
the quality of a model recombinant protein. You will participate to the establishment of the quality system
for the production of pre-clinical material
Profile
Candidates applying to this internship should bring fresh ideas, unique perspectives, and
fundamental knowledge. They should be passionate about science and engineering and their application
to biotechnology. They should thrive on the challenges associated with complex solving and working
with an international team. Candidates must be highly self-motivated and willing to work independently
while communicating results, progress and questions in a timely manner
Mission
The candidates should:
Study and excel in one the following preferred fields: biology, chemistry or other related science
fields, as well as chemical and biomedical engineering.
Have outstanding analytical ability and communication skills.

Experience working in research labs or industry and experience with animal cell culture and/or
bioreactors are highly desirable

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015
Manager with email and phone number for contact:
Gimenez Laura
Scientist :Upstream Process Sciences
Tel : +32-2-386 1870
Laura.Gimenez@ucb.com

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INTERNSHIP FOR 2015

N10 : Internship Cell Culture Process Development


Dept :Cell Culture Process Development Group (Braine LAlleud /Belgium)
Job description
As cell culture process development intern, you will evaluate the impact and criticality of a subset
of cell culture process parameters in fed-batch production. You will conduct laboratories cell
culture experiments to investigate the impact of operating process parameters on cells growth and
productivity as well as on the quality of a model recombinant protein. You also will apply statistical
methods to the design and analysis of experiments to determine the relationship between the
studied process parameters.
Profile
Candidates applying to this internship should bring fresh ideas, unique perspectives, and
fundamental knowledge. They should be passionate about science and engineering and their application
to biotechnology. They should thrive on the challenges associated with complex solving and working
with an international team. Candidates must be highly self-motivated and willing to work independently
while communicating results, progress and questions in a timely manner.
Mission
The candidates should:
study and excel in one the following preferred fields: biology, chemistry or other related science
fields, as well as chemical and biomedical engineering.
have outstanding analytical ability and communication skills.

Experience working in research labs or industry and experience with animal cell culture are
highly desirable.

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015
Manager with email and phone number for contact:
Clincke Marie-Franoise
Senior Scientist
Upstream Process Sciences
Tel : +32-2-386 1877
Marie-Francoise.Clincke@ucb.com

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INTERNSHIP FOR 2015

N 11 TechOps Data sciences


( Braine Belgium)
Job description
Support for SPDM project deployment.
Student will be missioned to :
- Create new data catalogues
- Create web page to capture data
- Support final users (manufacturing, laboratories, managers) to interpret data analysis
- Support final users to build and automatize dashboards to report data analysis
- Collect Data integration needs
Impact or relation with other UCB Team
Final users are all manufacturing, laboratories, CMO management teams in TechOps
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
Chemical Engineering or Biological or Pharma
Manager with email and phone number:
Jean-Etienne FORTIER
Associate Director Scientific Data Management
@: jean-etienne.fortier@ucb.com
P: +32 (2) 386 6395
M: +32 (495) 588 392
UCB pharma - B-1420 Braine l'Alleud, Belgium

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INTERNSHIP FOR 2015

N 12 TechOps Data sciences


( Braine Belgium)

Job description
Support for SPDM project deployment.
Student will be missioned to :
- Create new data catalogues
- Create web page to capture data
- Support final users (manufacturing, laboratories, managers) to interpret data analysis
- Support final users to build and automatize dashboards to report data analysis
- Collect Data integration needs
Impact or relation with other UCB Team
Final users are all manufacturing, laboratories, CMO management teams in TechOps
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q3 2015 for 6 months
Profil of student
Chemical Engineering or Biological or Pharma
Manager with email and phone number:
Jean-Etienne FORTIER
Associate Director Scientific Data Management
@: jean-etienne.fortier@ucb.com
P: +32 (2) 386 6395
M: +32 (495) 588 392
UCB pharma - B-1420 Braine l'Alleud, Belgium

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INTERNSHIP FOR 2015

N 13 Investigations into Donnan effect


( Braine Belgium)
Job description
The quantitation of excipients into the final formulation is becoming part of the quality of a Drug
Product and discrepancies between claimed and achieved concentrations of those should be limited. The
Donnan effect during the final UFDF might be responsible for these deviations especially at high protein
concentrations. Establishment of scale-down models (centrifugation on spin tube), implementation of
suitable analytical (CAD detector) and sample preparation techniques (protein removal) as well as
Donnan and/or Poisson-Boltzmann modelisation can certainly contribute to increase the UCB knowledge
and help design better controlled processes.
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q3 2015 for 6 months
Profil of student
Biological or / Analyst
Manager with email and phone number:
Peerboom Claude
Associate Director
Preformulation & Non-Clin Formulation
Tel : +32-2-386 6504
Claude.Peerboom@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

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INTERNSHIP FOR 2015

N 14 Evaluation of assay ruggedness of a relative


potency Binding ELISA used to assess the activity of
antibody-based drugs.
( Braine Belgium)
Job description
Bioassay development laboratory is looking for a trainee (6 to 9 months contract).
The Bioassay development group is looking for a trainee (6 to 9 months contract) in the frame of
routine cell culture activities (transformed cell lines (adherent and in suspension)) and bioassay
development (Ligand Binding Assay and/or cell-based assay (from classical proliferation tests till novel
alternative techniques such as flow cytometry, gene reporter assays)). The project will cover the
development/optimization of analytical methods as well as the assessment of method ruggedness (impact
on method performance of a variety of conditions such as different batches of key reagents, use of a plate
washer, assay performed on different days, ).
UCB is looking for a trainee with a good experience in ELISA and cell culture (Molecular
Biology/Cell Biology).
UCB offers the opportunity to discover a first experience in the industrial world in a GMP
environmentContract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
Molecular Biology, Cellular Biology
Manager with email and phone number:
Debauve Gael
Group Leader Bioassay Development
Bioassay Development
+32-2-386 2684
Gael.Debauve@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

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INTERNSHIP FOR 2015

N 15 Primary Packaging Components Optimization


for Freeze-Dried Products
( Braine Belgium)
Job description
The goal of this study would be to evaluate the impact of different primary packaging component
configurations (vials, stoppers) on the freeze-drying processes and on the quality of the freeze-dried
products. This would in the end lead to a potential optimization of the primary packaging components as
well as the freeze-drying processes.
This would include design of experiment aspects, packaging material understanding, freeze-drying
process development and optimization and freeze-dried product characterization, using appropriate
analytical techniques.
Impact or relation with other UCB Team
Interactions with Primary Packaging Development, Biological Formulation Development, Drug
Product Process Design and Development and Analytical Development.
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
Chemical Engineering or Biological or Pharma
Manager with email and phone number:
Jean-Franois Decoster
Head of Primary Packaging
Primary Packaging
Tel : +32-2-386 2651
Jean-Francois.Decoster@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

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INTERNSHIP FOR 2015

N 16 Review of cleaning monitoring and cleaning


validation strategy to a multi-product GMP pilot plant
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


J S.Cuypers*
Senior Scientist Formulation
Formulation and Process Development
Tel : +32-2-386 6056
Serge.Cuypers@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

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INTERNSHIP FOR 2015

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N 17 Assessment of spray-drying technology in the


formulation strategy of poorly soluble compounds case study
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description
.
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


J.Meeus
Scientist Formulation and Process Development
Tel : +32-2-386 6870
Joke.Meeus@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

23

INTERNSHIP FOR 2015

N 18 Assessment of continuous granulation process


in the early stage formulation strategy - case study
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


G.Pilcer
Scientist Formulation and Process Development
Tel : +32-2-386 7856
Gabrielle.Pilcer@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

24

INTERNSHIP FOR 2015

N 19 Development of a dissolution test for poorly


water-soluble compounds
( Braine Belgium)

D4P est un dpartement en charge du dveloppement des formulations non clinique de


nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


P. Somville
Senior Scientist Preformulation & NonClinical Formulation
Tel : +32-2-386 3451
Pascal.Somville@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

25

INTERNSHIP FOR 2015

N 20 Assessment of the adsorption, solubility and


stability of poorly soluble compounds to support hERG
and Purkinje studies
( Braine Belgium)

D4P est un dpartement en charge du dveloppement des formulations non clinique de


nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


W. Brione
Senior Scientist : Preformulation & NonClinical Formulation
Tel : +32-2-386 2699
Willy.Brione@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

26

INTERNSHIP FOR 2015

N 21 Feasibility of suspension formulations


according to particle size distribution
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


W. Brione
Senior Scientist : Preformulation & NonClinical Formulation
Tel : +32-2-386 2699
Willy.Brione@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

27

INTERNSHIP FOR 2015

N 22 Assessment of the absorption variability of


one drug under development according to animal
species
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


W. Brione
Senior Scientist : Preformulation & NonClinical Formulation
Tel : +32-2-386 2699
Willy.Brione@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

28

INTERNSHIP FOR 2015

29

INTERNSHIP FOR 2015

N 23 Development of dry powder nanoparticles


processes
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


R. Chirico
Associate Scientist : Preformulation & NonClinical Formulation
Tel : +32-2-386 2653
Rosana.Chirico@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

30

INTERNSHIP FOR 2015

N 24 Nanostructured Lipid Carrier formulations for


brain delivery of poorly compounds
( Braine Belgium)
D4P est un dpartement en charge du dveloppement des formulations non clinique de
nouvelles entits chimiques, et des formulations cliniques des premires tudes chez
lhomme jusquau lancement commercial des produits. Au sein de notre dpartement, vous
serez intgr aux quipes internes de formulation and dveloppement des procds et
participerez :
au dveloppement de nouvelles formules
au design de procds de fabrication et leur transposition
ventuellement au dploiement de nouvelles technologies

Job description

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
1.Pharmacien et / ou Ingnieur
2. Bonne comprhension des oprations unitaires de procd pharmaceutiques
3. Connaissance de la mthodologie des plans dexpriences
4. Bon niveau en anglais

Manager with email and phone number:


R. Chirico
Associate Scientist : Preformulation & NonClinical Formulation
Tel : +32-2-386 2653
Rosana.Chirico@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

31

INTERNSHIP FOR 2015

N 25 Manufacturing plants
( Braine Belgium)
Job description
In a new production facility a movable rotative dryer, although fir for purpose in terms of
production deliverables, needs to be completely redesigned in order to make it safe to operate for the
operators. With the current design, the dryer structure is far too heavy (total weight: 2800kg) and makes it
difficult to move it in a safe manner.
The objective of this placement will be to review the design of this equipment; we will keep the
drum of the dryer but we want to modify its supportive structure in order to reduce the total weight by at
least 1000kg

Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
Mechanical or Chemical Engineering
Manager with email and phone number:
Michel Liesenborgh]
Head of BTO Engineering : BTO Engineering
Tel : +32-2-386 3092
Michel.Liesenborghs@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

32

INTERNSHIP FOR 2015

N 26 MeOH/NH3 Distillation optimization


( Braine Belgium)
Job description
Improve mode of operation of a MeOH/NH3 distillation, focusing on the column control scheme.
Optimisation of the reflux and heating PID control loop parameters.
Definition of the optimal operation envelop.
Optimisation of utilities consumption.
Contribute/participate to the update of the GMP procedures of starting up ammonia column and the
training of operational staff
Contract:
6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for 6 months
Profil of student
Chemical Engineering
Manager with email and phone number:
Younes Aarifi
Team Leader Production B2 : Production B2
Tel : +32-2-386 4070
Younes.Aarifi@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

33

INTERNSHIP FOR 2015

N 27 Continuous Chemical process: step 2: chemical


reaction
( Braine Belgium)
Job description
We are developing a full continuous process from raw material to API, which contains 3 reactions
steps, 2 or 3 purification steps and 1 crystallization step.
This project has started in January 2013 and good results, that means the POC (Proof Of Concept)
of each step is present but we need to optimize each step with the integration of the purification step .
The student must :
Optimize operating conditions of reaction with determination of kinetic rate in continuous
flow taking account the main by-product formation.
Optimize the continuous purification step in order to get the right specifications for the next
step.
Have a good knowledge of different analytical methods ( A training is planned)
CONFIDENTIAL PROJECT
Contract:
Mini 5- 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for at less 6 months
Profil of student
Chemical Engineering or chemist
The student must work in team, with a good communication.
All reports and oral presentation will be done in english
Manager with email and phone number:
Edith Lecomte Norrant
Dir Innovation & Technology Development
Innovation & Scientific Liaison
Tel : +32-2-386 2203
edith.norrant@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

34

INTERNSHIP FOR 2015

N 28 Continuous Chemical process: step 3 chemical


reaction
( Braine Belgium)
Job description
We are developing a full continuous process from raw material to API, which contains 3 reactions
steps, 2 or 3 purification steps and 1 crystallization step.
This project has started in January 2013 and good results, that means the POC (Proof Of Concept)
of each step is present but we need to optimize each step with the integration of the purification step .
The student must :
Optimize operating conditions of reaction with determination of kinetic rate in continuous
flow taking account the main by-product formation.
Optimize the continuous purification step in order to get the right specifications for the next
step.
Have a good knowledge of different analytical methods ( A training is planned)
CONFIDENTIAL PROJECT
Contract:
Mini 5- 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for at less 6 months
Profil of student
Chemical Engineering or chemist
The student must work in team, with a good communication.
All reports and oral presentation will be done in English
Manager with email and phone number:
Edith Lecomte Norrant
Dir Innovation & Technology Development
Innovation & Scientific Liaison
Tel : +32-2-386 2203
edith.norrant@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

35

INTERNSHIP FOR 2015

N 29 Continuous Chemical process: step 5


Crystallization
( Braine Belgium)
Job description
We are developing a full continuous process from raw material to API, which contains 3 reactions
steps, 2 or 3 purification steps and 1 crystallization step.
This project has started in January 2013 and good results, that means the POC (Proof Of Concept)
of each step is present but we need to optimize each step with the integration of the purification step .
The student must :
Optimize operating conditions of continuous crystallization step with determination of
kinetic rate in continuous flow taking account the main by-product formation.
Optimize the continuous separation solid/liquid phase in order to get the right
specifications of particle size distribution.
Have a good knowledge of different analytical methods ( A training is planned)
CONFIDENTIAL PROJECT
Contract:
Mini 5- 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for at less 6 months
Profil of student
Chemical Engineering or chemist
The student must work in team, with a good communication.
All reports and oral presentation will be done in English
Manager with email and phone number:
Edith Lecomte Norrant
Dir Innovation & Technology Development
Innovation & Scientific Liaison
Tel : +32-2-386 2203
edith.norrant@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

36

INTERNSHIP FOR 2015

N 30 Continuous Chemical process: step 4


separation
( Braine Belgium)
Job description
We are developing a full continuous process from raw material to API, which contains 3 reactions
steps, 2 or 3 purification steps and 1 crystallization step.
This project has started in January 2013 and good results, that means the POC (Proof Of Concept)
of each step is present but we need to optimize each step with the integration of the purification step .
The student must :
Test different technologies concerning the separation of enantiomers. ( innovative chemical
technology)
Optimize the operating condition of the best one technology of purification in order to get
the right specifications for the next step.
Have a good knowledge in chemistry and in different analytical methods ( A training is
planned)
CONFIDENTIAL PROJECT
Contract:
Mini 5- 6 Months full time
Indemnity ( 750/month)
Adress of the Site :
UCB Pharma
Avenue de lindustrie 1420 Braine lAlleud Belgium
Started date :
ASAP : Q1 2015 for at less 6 months
Profil of student
Chemist or Chemical Engineering
The student must work in team, with a good communication.
All reports and oral presentation will be done in English
Manager with email and phone number:
Edith Lecomte Norrant
Dir Innovation & Technology Development
Innovation & Scientific Liaison
Tel : +32-2-386 2203
edith.norrant@ucb.com

UCB pharma - B-1420 Braine l'Alleud, Belgium

37

INTERNSHIP FOR 2015

38

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