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4
The
Galapagos,
home
of
the
Galapagos
nches
Processes
thought
to
have
driven
specia+on
of
Galapagos
nches
are
s+ll
happening.
In
this
case
adap+ve
(posi+ve)
selec+on
for
larger
body
size
q2 = 0.375
q2 = 0.4375
10
11
Random genetic drift . The graph on the left is a simulation of drift with 16 individuals, in 107
populations that are initially heterozygous. The messier graph on the right is a real - life experiment
with 16 individuals that were heterozygous for the bw/bw75 allele that shows the same pattern
expected for a small population that is drifting in allele frequency.
[Data in part (A) from P. Buri. 1956. Evolution 10: 367. Graphs from D. L. Hartl and A. G. Clark.
1989. Principles of Population Genetics. Sunderland, MA: Sinauer Associates]
14
external nodes
internal nodes
16
17
Gene+cs
of
reproduc+vely
independent
lineages
(e.g.
species)
addresses
lineage
ex+nc+on
and
ancestral
rela+onships
represented
as
phylogenies,
here
as
a
branching
tree.
In
an
environment
that
limits
their
number,
through
selec+on
or
by
chance,
some
of
the
chromosome
or
gene
lineages
will
go
ex'nct
and
they
will
be
replaced,
by
other
expanding,
diverging
clades
(ancestor
and
its
descendants).
20
Related sequences
(RNA pol II in L.
Bromham
Reading the DNA
story ) show a
nested hierarchy
of substitutions
under strong
stabilizing
selection related to
divergence times:
Human- rat- 4bp
0 AA chg
Human- fly-9bp
0 AA chg
Human
Fungus-11bp 1 AA
chg
Human -plant-20bp
6 AA chg
Human-E coli-23bp
8 AA chg
22
globin
Nucleo+des
in
which
posi+on
(rst,
second
,
third
base
in
a
codon)
are
evolving
the
fastest
?
Why
?
func+onal
constraints.
Between
introns
and
exons,
which
might
be
the
fastest
evolving
?
23
Gene+c
Varia+on
among
Geographic
races
24
Paleontologist
generally
agree
that
Homonids
evolved
in
Africa
un+l
1-2
million
years
ago.
There
are
two
main
theories
about
subsequent
evolu+on
of
Homo
sapiens:
26
40,000
20,000
100,000 yr
130,000
70,000
50,000
28