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CO2H
H3N
10.53
H
CH2CH2CH2CH2NH3
8.95
A)
B)
C)
D)
2.18
5.56
6.36
9.74
2. The Fischer projection shown below denotes a ______ amino acid which has the _____
configuration.
-
CO2
H3N
H
CH2C6H5
A)
B)
C)
D)
D, S
D, R
L, S
L, R
1)
is 1
is 2
is 3
is 4
Page 1
4. What is the total number of different tripeptides which can result from three different Lamino acids?
A) three
B) four
C) six
D) nine
5. A pentapeptide was found to contain the amino acids ala, gly, met, phe, and ser. Partial
hydrolysis of the pentapeptide gave the dipeptides gly-ser, met-phe, ala-gly, and sermet. What is the sequence of the pentapeptide?
A) gly-ser-met-phe-ala
B) gly-ser-met-ala-phe
C) ala-gly-ser-phe-met
D) ala-gly-ser-met-phe
6. Which one of the following is the final product of the reaction sequence shown below?
O
H3C
H2O, H
heat
(2) (CH3)2CHCH2Br
O
1) (CH3)2CHCHCO2H
3) CH3CNHCH2CH(CH3)2
OH
2) (CH3)2CHCH2CHCO2H
4) (CH3)2CHCH2CO2H
NH2
A)
B)
C)
D)
is 1
is 2
is 3
is 4
7. The peptide linkage in proteins and peptides is planar and has restricted rotation about
the carbon-nitrogen bond because:
A) the peptide bond has partial double bond character.
B) hydrogen bonding requires a planar arrangement and restricts bond rotation.
C) the steric hindrance of the large side chains.
D) the carbonyl is predominately in the enol form.
Page 2
8.
A)
B)
C)
D)
Two cysteine side chains of a polypeptide are often connected to each other by a(an):
ionic bond
hydrogen bond
disulfide bond
peptide bond
9. Identify the missing starting reagent needed in the Strecker synthesis of isoleucine.
(Assume you will get all the stereoisomers of isoleucine.)
NH4Cl
(1) H2O, HBr, heat
?
H3NCHCO2
NaCN
(2) NaOH
CHCH2CH3
CH3
Br
1)
O
2)
3)
Br
4)
H
A)
B)
C)
D)
is 1
is 2
is 3
is 4
10.
A)
B)
C)
D)
Which one of the following reagents is used for the visual detection of amino acids?
Sanger's reagent
dicyclohexylcarbodiimide (DCCI)
ninhydrin
phenyl isothiocyanate
Page 3
11. Which of the following Fischer projections corresponds to the compound shown below?
H OH
H3C
CH3
H Br
CH3
1)
OH
Br
CH3
A)
B)
C)
D)
CH3
2)
OH
Br
CH3
3)
HO
Br
CH3
CH3
4)
HO
Br
CH3
CH3
is 1
is 2
is 3
is 4
13.
A)
B)
C)
D)
14.
A)
B)
C)
D)
Page 4
is 1
is 2
is 3
is 4
16. Which of the following is the open-chain form of the pyranose structure shown below?
HO OH
HO
H
HO
OH
H
A)
B)
C)
D)
OH
H
is 1
is 2
is 3
is 4
Page 5
17. The principal difference between amylose (from starch) and cellulose is:
A) amylose has exclusively (1,4)-linked glucose and cellulose has exclusively (1,4)linked glucose.
B) amylose has exclusively (1,6)-linked glucose and cellulose has exclusively (1,4)linked glucose.
C) amylose has (1,4)-linked glucose with (1,6) branches and cellulose has exclusively
(1,4)-linked glucose.
D) amylose has exclusively (1,4)-linked glucose and cellulose has (1,4)-linked glucose
with -(1,6) branches.
18. How would the glycosidic linkage indicated by the arrow be described for the following
disaccharide?
HO OH
HO
H
HO
OH
H
OH
H O
HO
HO
HO
OH
H
OH
H
A)
B)
C)
D)
(1,5)
(1,6)
(2,6)
(1,6)
19.
A)
B)
C)
D)
Page 6
20. What are the configurations of carbons 2 and 3 in the Fischer projection below.
CH3
H 2
Br
A)
B)
C)
D)
OH
H
CH3
2R, 3R
2R, 3S
2S, 3R
2S, 3S
Page 7
Answer Key
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
D
C
B
C
D
B
A
C
D
C
A
A
C
B
D
A
A
B
D
D
Page 8