4/12/2015

CiproI.V.(CiprofloxacinIV)DrugInformation:Description,UserReviews,DrugSideEffects,InteractionsPrescribingInformationatRxList

April12,2015

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WARNING
Fluoroquinolones,includingCIPROI.V.(ciprofloxaciniv),areassociated
withanincreasedriskoftendinitisandtendonruptureinallages.Thisrisk

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isfurtherincreasedinolderpatientsusuallyover60yearsofage,in

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Toreducethedevelopmentofdrugresistantbacteriaandmaintainthe
effectivenessofCIPROI.V.(ciprofloxaciniv)andotherantibacterialdrugs,
CIPROI.V.(ciprofloxaciniv)shouldbeusedonlytotreatorpreventinfections
thatareprovenorstronglysuspectedtobecausedbybacteria.

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CIPROI.V.(ciprofloxacin)isasyntheticbroadspectrumantimicrobialagent
forintravenous(I.V.)administration.Ciprofloxacin,afluoroquinolone,is1
cyclopropyl6fluoro1,4dihydro4oxo7(1piperazinyl)3
quinolinecarboxylicacid.ItsempiricalformulaisC17H18FN3O3andits
chemicalstructureis:

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Ciprofloxacinisafainttolightyellowcrystallinepowderwithamolecular
weightof331.4.Itissolubleindilute(0.1N)hydrochloricacidandis
practicallyinsolubleinwaterandethanol.CIPROI.V.(ciprofloxaciniv)

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CiproI.V.(CiprofloxacinIV)DrugInformation:Description,UserReviews,DrugSideEffects,InteractionsPrescribingInformationatRxList

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solutionsareavailableassterile1%aqueousconcentrates,whichare
intendedfordilutionpriortoadministration,andas0.2%readyforuse
infusionsolutionsin5%DextroseInjection.Allformulascontainlacticacidas
asolubilizingagentandhydrochloricacidforpHadjustment.ThepHrange
forthe1%aqueousconcentratesinvialsis3.3to3.9.ThepHrangeforthe
0.2%readyforuseinfusionsolutionsis3.5to4.6.
Theplasticcontainerislatexfreeandisfabricatedfromaspecially
formulatedpolyvinylchloride.Solutionsincontactwiththeplasticcontainer
canleachoutcertainofitschemicalcomponentsinverysmallamounts
withintheexpirationperiod,e.g.,di(2ethylhexyl)phthalate(DEHP),upto5
partspermillion.Thesuitabilityoftheplastichasbeenconfirmedintestsin
animalsaccordingtoUSPbiologicaltestsforplasticcontainersaswellasby
tissueculturetoxicitystudies.

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Whataretheprecautionswhentakingciprofloxaciniv(Cipro
I.V.)?
Beforeusingciprofloxacin,tellyourdoctororpharmacistifyouareallergictoit
ortootherquinoloneantibiotics(suchasgatifloxacin,levofloxacin)orifyou
haveanyotherallergies.Thisproductmaycontaininactiveingredients,which

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cancauseallergicreactionsorotherproblems.Talktoyourpharmacistformore

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details.
Beforeusingthismedication,tellyourdoctororpharmacistyourmedicalhistory,
especiallyof:seizures,conditionsthatincreaseyourriskofseizures(suchas

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brain/headinjury,braintumors,cerebralatherosclerosis),nerveproblems(such
asperipheralneuropathy),kidneydisease,liverdisease,myastheniagravis,

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druginteractions

joint/tendonproblems(suchastendonitis,bursitis),heartproblems(suchas
slow/fast/irregularheartbeat,recentheart...
ReadAllPotentialPrecautionsofCiproI.V.

SeeInteractions
LastreviewedonRxList:12/30/2008
Thismonographhasbeenmodifiedtoincludethegenericandbrandnameinmany
instances.

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theFDA.VisittheFDAMedWatchwebsiteorcall1800FDA1088.

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