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Premature Birth
Health care providers consider labor to be preterm if it
starts before 37 weeks of pregnancy. Because a fetus is not
fully grown at 37 weeks, and it may not be able to survive
outside the womb, health care providers will often take
steps to stop labor if it starts before this time. Common
methods for trying to stop labor include bed rest and
medications that relax the muscles in the uterus involved
with labor and delivery.
However, the American College of Obstetricians and
Gynecologists (ACOG) recently reported that many of
the methods used to stop preterm labor are ineffective.
The ACOG announcement confirms NICHD-supported
research (National Institute of Child Health and Human
Development), which found that home uterine
monitors were not effective for predicting or
preventing preterm labor.
If efforts to stop labor fail, then the baby could be born
prematurely. Premature infants face a number of health
challenges, including low birth weight, breathing problems,
and underdeveloped organs and organ systems. Many
infants that are born prematurely need to stay in the
hospital until their health is stable, sometimes several
weeks or more.
treating these infections that may reduce the risk of premature birth. For more information on this research, read
the news release on the bacterial vaginosis and the news
release on trichomoniasis.
One effective way to understand preterm labor and
premature delivery is to study the characteristics of women
who have given birth prematurely. One group of NICHDsupported researchers found that, among women who
had given birth prematurely in the past, a shortened cervix
could be a warning sign in preterm labor for a current
pregnancy. With this knowledge, scientists can work to
develop ways of preventing this shortening of the cervix,
which may help to prevent preterm labor and premature
delivery. For more information on this research, read the
news release about shortened cervix and premature birth.
In addition, research on preterm labor and premature birth
is ongoing through the NICHDs Maternal-Fetal Medicine
Units (MFMU) Network, a research program that uses 14
sites around the country to conduct studies related to the
mechanisms of pregnancy and birth. Researchers in the
MFMU Network recently completed a clinical trial, which
showed that the hormone progesterone may prevent
repeated premature birth in a specific group of women,
those who were carrying a single fetus, and who
previously gave birth prematurely, between 20 and 26
weeks of pregnancy. In this trial, the progesterone
treatment started between the 16th and 20th week of
pregnancy, and continued through the 36th week of
pregnancy. This finding may help to reduce future
premature births among women who have a history of
preterm labor and premature delivery.
NICHD-supported researchers were also working to see
whether having more uterine contractions during pregnancy
could be a warning sign of premature birth. Many pregnant
women have uterine contractions throughout their
pregnancies. These contractions are often mild and usually
occur after the mid-way point of pregnancy. But, this
research showed that, even though how often a woman
had contractions was significantly related to premature
birth, it wasnt an effective way to predict which mothers
would give birth prematurely.
The NICHD and other NIH Institutes are currently conducting
a number of clinical trials related to premature birth.
WARNING: Ingestion of more than 3 grams of omega-3 fatty acids (such as DHA) per day has been shown to have potential antithrombotic effects,
including an increased bleeding time and International Normalized Ratio (INR). Administration of omega-3 fatty acids should be avoided in patients
taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding.
WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach
of children. In case of accidental overdose, call a doctor or poison control center immediately.