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Immunohaematology I
Lesson 13:
Other Blood Group Systems
Anti-Leb
Usually produced by Le(a-b-) individuals
May also be seen in Le(a+b-) phenotype
Usually an IgM, room temperature-reactive
Anti-i
A rare antibody
Usually an IgM cold agglutinin
Development of a potent autoanti-i is
sometimes associated with infectious
mononucleosis and may cause a transient
hemolytic anemia
Anti-P
Alloanti-P
Produced only by individuals of the P1k or P2k
phenotypes
A potent hemolysin and must be considered
significant when selecting blood for transfusion
Autoanti-P
Associated with an autoimmune hemolytic
anemia known as paroxysmal cold
hemoglobinuria
Potent IgG hemolysin
Anti-PP1Pk
Produced by all individuals with the p
phenotype
A potent, naturally occurring hemolysin that
may be either IgM or IgG
Women of the p phenotype have an increased
incidence of spontaneous abortion
Anti-N
An uncommon antibody
Usually a weak, cold-reactive, naturally
occurring IgM agglutinin produced by
individuals who are M+N- and who are
positive for S or s
Many anti-N sera demonstrate antigen dosage
on RBCs
It is not considered clinically significant unless
antibody reactions occur at 37C
Anti-U
A rare antibody reactive at 37C and the
antiglobulin phase with the cells of most
normal individuals
Should be considered clinically significant and
has been associated with severe HDN and HTR
Identification can be difficult due to the
scarcity of U-negative cells for testing
Anti-FY3
Reacted equally well in with enzyme-treated or
untreated cells
Immune mediated, but transfusion appears to be a
much stronger stimulus than pregnancy
Anti-FY4
Resembles anti-FY3, reacted equally well in with
enzyme-treated or untreated cells
Anti-FY5
Reacted only with cells having normal Rh antigens and
Fya or Fyb antigens
Like FY3 and FY4, the FY5 antigen is not destroyed by
proteolytic enzyme