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Cu 32: ptio nh tng(bromoform)

Thnh phn
Hng
pha
bromoform
2g
Du
Na benzoat

4g

Nc

Du lc

10g

Du

Codein
phosphat

0,2g

Nc

Gm arabic

9g

Nc

Sirocodein

20g

Nc

Nc ct v

100ml

Nc

_____________
Vai tr
Dc cht: an thn,
d ho
Dc cht, long
m
Dung mi ha tan
cc cht tan trong
du
Dc cht: du ho
do tc dng ln
trung tm ho
Cht nh ha n
nh cho NT D/N
iu v (ngt): n
nh
nh
tng( tng
nht, tng d pha
ngoi)
Mi trng

*ch
+tnh cht ca bromorm -kch ng nim mc -mu v kho chu
-t tan/nc, tan/du
bo ch dng nh tng D/N, che du mi v kho chu, gim
kch ng, tng n nh.
+Na benzoat: tan chm trong nc nn un nng khi ha tan
+Gm arabic: d ht m nu nghin trong ci kh
+Siro n- codeinphosphat: khng th thay bng siro codein v
khng hm lng codein.
*phng php bo ch: phng php s dng cht nh ha
dng bt kh
*cu trc nh tng: D/N
*cch tin hnh:
-cn v nghin tht mn 9g gm arabic trong ci sch v kh
-Ha tan 2g bromoforn vo 10ml du lc
-Cho pha du vo gm o nh cho u, thm 18ml nc, d
chy nh, nhanh, lin tc to thnh nh tng c
-ha tan Na benzoat trong khong 20ml nc nng, ha tan tip
codein phosphat.
-Dng lc nc cn li pha long nh tng c.
-Phn hp dd Natri benzoat-codein phosphat v siro n vo
nh tng pha long.
-B sung nc va 100ml
-ng chai, dn nhn ng quy ch
*Cng dng, cch dng, bo qun
-thuc ung lm d ho-long m
-liu dng: 1 thia cnh/ln x 2-3 ln/ngy
-bo qun: ni mt-hn dng 2 ngy
___________________
Cu33:Clotrimazol,Betamethazon,Dipropionat(nh tng)
Thnh phn
hlg
pha
Vi tro
Clotrimazol
1,000g
Nc
Dc cht: tr nm,
tan/propylen glycol
Betamethazon
0.064
Du
Dc cht: chng
Dipropionat
vim
Gendamicin
0.100g
N
Dc cht: iu tr
sulfat
nhim khun
-alcol cetylic
5,000g
D
Alcol bo
-alcol stearic
-mm da, du da
-kh nng nh ha
rt yu cho NT N/D
t dc iu chnh
th cht, tng
cng, mn, kh
nng nh ha v lm
du ca cc t dc
Vaselin

5,500g

iu chnh th cht,
nh ha yu,NT N/D
Dung mi ha tan
cc cht tan trong
du pha ni
Dc
cht
siliconbo v da,
khng thm su
Cht nh ha cho
NT. N/D

Du parafin

9,000g

Dimethicon

5,000g

Sorbitan
monostearat
(span)
Polysabat 80

1,500g

2.000g

Natri benzoat

0,200g

Clycerin

5,000g

Propylen clycol

5,000g

Butyl
hydroxy tuluen
Nc tinh khit

0,040g

Cht nh ha cho
NT. D/N
Cht
bo
qun:
chng nm, st khun
Lm
tng

nhtn nh nh
tng
Dm
ha
tan
clotrimazol,
gim
tnh i khang ca
lp sng
Chng oxy ha

100g

Dung mi pha ngoi

+cu trc nh tng: D/N ( trong cng thc phi hp cc cht


nh ha cho NT D/N v N/D to lp o kp quanh tiu phn
tn nh tng n nh)
+phng php bo ch: phng php ha tan cht nh ha
-cn (alcol cetylic,alcol stearic, vaselin)cho vo bt sdun
nng cho chy lng cc t dc.
-Cn (Betamethazon Dipropionat, sorbitan monostearat(span),
Butyl hydroxy tuluen) ha vo hn hp trnpha du
un nng 10ml nc(t0: 65-70) cho Natri benzoat voha tan
Ha tan clotrimazol vo propylen glycol ri phi hp vi dng
dch Natribenzoat v glycerinpha ncun nng(t0~65-700c)
-phi hp 2 pha: phi nng( trong ci ra sch nng nhanh
pha nc vo pha du)
-trn nhanh, mnh, 1 chiu n khi thu c nh tng ng nht
-ng l ng quy cch

Cu 34: injectable diazepamemulsion(nh tng)


Thnh phn
Hng
pha
Va tro
Diazepam
0,5%
D
Duocj cht: an thn
gy ng
Soybean oil
20,0
D
Dm pha ni(ha tan
(du u lnh)
cc cht tan/du)
Egg
yolk
1,2
N
Cht nh hanh
phospholipids
tng D/N d b
(lecithim)
oxy ha bi nh
sng, nhit ,
m/OH-dng cht
chng oxy ha
Doloxamer
N
Cht nh hanh
tng D/Nlm
tng tan
Glycerin
N
Tng nhtNT
D/N, tng tan.
-tocoferol
0,02
D
Cht chng oxy ha
- Methyl paraben
0,2
N
Cht bo qun
-propyl paraben
0,075
N
chng nm mc
Distilled woder
1%
N
Dmpha ngoi
+cu trc nh tng D/N
+phng php bo ch: phng php ha tan CNTC
-cn du u nnh vo bt sun nng, Cn diazepam, tocoferol cho vo ha tan duy tr nhit pha~60-650c
-ngm poloxamer/nc m n trng n hon ton
-ha tan methyl paraben, propyl paraben trong nc nng(6570oc).
ho tan lecithin thm glycerinphi hp vi cc cha
poloxamer trng n hon ton
( dy tr nhit pha 65-70oc).
+phi hp 2 pha(phi nng)dng lc phn tn to thnh nh
tng ng nht.
____________________
Cu 35:intravenous Taxolemulsion(nh tng)
Thnh phn
H lg
pha
Vi tro
Taxol
1,00%
D
Dc:(-)ging
(pactilaxel)
phnchng
ung th
Lecethin(soy)
1,5
N
Dc: NT D/N
Poloxamer 188
1,5
N
CNH: NT D/N
Lam tng tan
Triacetin
50,0
D
Dmpha ni
(glycerol
triacetate)
Ethyl oleat
2,0
D
Dtilled water
44,00
N
Dm pha ngoi
+cu trc nh tng D/N
+phng php bo ch: CNH
-cn triacetin vo cc thy tinh( hoc bt s) un nng n
khong 60o cho tip tc ethyl oleat, taxol vo khuy
utan ht( tO~60-65o)
-ngm poloxamer 188 trong nc m n trng n hon ton
-un lng nc cn li65-70o ha tan lecithinphi hp
vi poloxamer188 trng n hon ton(pha N)
-phi hp 2pha trong ci s sch, nng, dng lc gy phn tn
to thnh nh tng ng nht.
+ng ng, dn nhn ng quy cc
Ch : lc trc khi dng
____________________
Cu 36:intravenous propofol emulsion(nh tng)
Thnh phn
H lg
pha
Vi tro
Propofol
200mg
D
Dc: gy m, an
thn
-glycerol
400mg
N
Glyceryl
mn
-oleic acid
6mg
N
oleatCNH:
NT, D/N
Lecithin/ trng
240mg
D
CNH: NT D/N
g
Soya oil for
2mg
D
Dmpha ngoi
injection
ni
sodium
0,5
N
iu chnh ph
hydroclorid
Ph(,5~8,5)
0,1 N
Nc
N
Dmpha ngoi
+cu trc nh tng: D/N
+phng php bo ch: ha tan cht nh ha
-Can du u nnh vo c thy tinhun nng 60-65o
ha tan propofol vo acid oleic(t o 60-65o)
-ung nng nc n 65-70o
ha tan glycerol v lecithin vo.
-phi hp 2 pha (phi nng)
dng lc phn tnn khi thu c nh tng ng
nhtiu chnh ph=dung dch NaOH 0,1N n ph:7,5-8,5
+ng ng: dn nhn ng quy cch
+ch : lc k trc khi dng.
____________________

Cu 37:cream: Mineral oil ,Glycerin stearat(nh tng)


Thnh phn
Hlg
Pha
Vi tro
Mineral oil
3,6%
D
Dm ha tan cc cht tan/D
Glycerin
1,4
D
CNh cho nh tng N/D
stearat
Cetyl alcohol
1,5
D
CNh rt yu cho NT N/D
nhung n nh cu trc NT
D/N, iu chnh th cht,
lm mm du da.
Petrolatum
0,4
D
Stearic acid
1,6
D
Acid stearic+triethanolamin

triethanolaminstearatCNH
D/N
dimethycon
0,6
D
Dc:silicon c tc dng bo
v da,lm, khng thm su
Triethanolamin
0.1
D
Kch thch a cid atearicsn
phmCNH NT D/N
Acetylat
2,0
D
lanolin
Alcohol
Glycerin
3,5
N
Lm tng nhtn nh
nh tng
Presevative
9,5
N
Cht bo qun chng nm
mc
Nc
83,8
N
Dm ha tan cc cht tan/N
+cu trc nh tng: D/N
+phng php bo ch: ha tan cht nh ha
-Cn mineral oil, cetyl alcohol,glycerin, stearat, petrolatum,
acetylat anolin, dimethycon, acid stearic vo bt sn 6065oh2 chy lng duy tr nhit pha d 60-65o
-un
nc
ct
n
65-70 oha
tan,
presevative+glycerin+triethanolamin(phi nng)
-phi hp 2 pha( pha nng vo ci s sch kh.
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