Mode of Transmission of Malaria

1. Mosquito-Borne Malaria
The malaria parasite typically is transmitted to people by mosquitoes belonging to the
genus Anopheles.
Outbreaks of locally transmitted cases of malaria in the United States have been small and
relatively isolated, but the potential risk for the disease to re-emerge is present due to the
abundance of competent vectors, especially in the southern states. At the request of the states,
CDC assists in these investigations of locally transmitted mosquito-borne malaria.

2. "Airport" Malaria
"Airport" malaria refers to malaria caused by infected mosquitoes that are transported
rapidly by aircraft from a malaria-endemic country to a non-endemic country. If the local
conditions allow their survival, they can bite local residents who can thus acquire malaria
without having traveled abroad.

3. Congenital Malaria
Malaria also may be transmitted from a mother to her fetus before or during delivery
("congenital" malaria). In congenital malaria, infected mothers transmit parasites to their child
during pregnancy before or during delivery. Therefore, though congenital transmission is rare,
health-care providers should be alert to the diagnosis of malaria in ill neonates and young infants,
particularly those with fever.
During evaluation, health-care providers should obtain a complete and accurate travel and
residency history on the patient and close relatives. Patients should be asked about transfusion of
blood products.
The absence of recent foreign travel or a long interval between immigration of the mother
and the birth of the infant being examined should not discourage clinicians from obtaining blood
films on the patient to rule out a potentially life-threatening but treatable infection.

4. Transfusion-Transmitted Malaria
Because the malaria parasite is found in red blood cells, malaria can also be transmitted
through blood transfusion, organ transplant, or the shared use of needles or syringes
contaminated with blood.
Transfusion-transmitted malaria is rare in the United States, but it is a potential severe
complication in blood recipients. On average, only one case of transfusion-transmitted malaria
occurs in the United States every 2 years. Because no approved tests are available in the United
States to screen donated blood for malaria, prevention of transfusion-transmitted malaria requires
careful questioning of prospective donors.

Life Cycle of Malaria Parasites (Plasmodium sp.)

The natural ecology of malaria involves malaria parasites infecting successively two types
of hosts: humans and female Anopheles mosquitoes. In humans, the parasites grow and multiply
first in the liver cells and then in the red cells of the blood. In the blood, successive broods of
parasites grow inside the red cells and destroy them, releasing daughter parasites ("merozoites")
that continue the cycle by invading other red cells.
The blood stage parasites are those that cause the symptoms of malaria. When certain
forms of blood stage parasites ("gametocytes") are picked up by a female Anopheles mosquito
during a blood meal, they start another, different cycle of growth and multiplication in the
mosquito.
After 10-18 days, the parasites are found (as "sporozoites") in the mosquito's salivary
glands. When the Anopheles mosquito takes a blood meal on another human, the sporozoites are
injected with the mosquito's saliva and start another human infection when they parasitize the
liver cells.
Thus the mosquito carries the disease from one human to another (acting as a "vector").
Differently from the human host, the mosquito vector does not suffer from the presence of the
parasites.

The malaria parasite life cycle involves two hosts. During a blood meal, a malaria-infected
female Anopheles mosquito inoculates sporozoites into the human host (1). Sporozoites infect
liver cells (2) and mature into schizonts (3), which rupture and release merozoites (4). (Of note,
in P. vivax and P. ovale a dormant stage [hypnozoites] can persist in the liver and cause relapses
by invading the bloodstream weeks, or even years later.) After this initial replication in the liver
(exo-erythrocytic schizogony (A)), the parasites undergo asexual multiplication in the
erythrocytes (erythrocytic schizogony (B)). Merozoites infect red blood cells (5). The ring stage
trophozoites mature into schizonts, which rupture releasing merozoites (6). Some parasites
differentiate into sexual erythrocytic stages (gametocytes) (7). Blood stage parasites are
responsible for the clinical manifestations of the disease.
The gametocytes, male (microgametocytes) and female (macrogametocytes), are ingested
by an Anopheles mosquito during a blood meal (8). The parasites multiplication in the mosquito
is known as the sporogonic cycle (C). While in the mosquito's stomach, the microgametes
penetrate the macrogametes generating zygotes (9). The zygotes in turn become motile and
elongated (ookinetes) (10) which invade the midgut wall of the mosquito where they develop
into oocysts (11). The oocysts grow, rupture, and release sporozoites (12), which make their way
to the mosquito's salivary glands. Inoculation of the sporozoites (1) into a new human host
perpetuates the malaria life cycle.
Workflow Management of Malaria Post

Method of Malaria Treatment According to Health Ministry Standards

CDC. (n.d.). About Malaria. Retrieved from http://www.cdc.gov/malaria/about/biology/ and

http://www.cdc.gov/malaria/about/us_transmission.html. June 8th 2015
NIAID.
2009.
Understanding
Malaria-Transmission.
Retrieved
from
http://www.niaid.nih.gov/topics/malaria/understandingmalaria/pages/transmission.aspx.
June 8th 2015.