UNIVERSITY OF SANTO TOMAS

Faculty of Pharmacy
An Outcomes-based Teaching Learning Program for Phar. Chem 1
2nd semester, A.Y. 2014-2015

Course Title:
Course Number:

Pharmacy and Chemistry of Inorganic Medicinals

Phar. Chem 1

Credit Units:
Contact Hours:

5 units; 3 units lecture and 2 units laboratory

Three (3) hours lecture/week and 6 hours laboratory/week

Course Placement:

First year level, 2nd semester

Pre-requisite:
Course Facilitator:

Chemistry 100
Assoc. Prof. Ma. Elena J. Manansala, M.S.Phar..

Assoc. Prof. Cristina Doria, MS Phar

Asst.Prof. Mary Catherine Chua, M.Ed, M.S. Phar. Analysis
Asst. Prof. Marife Narcida, M.S. Phar. Analysis
Course Description:

Covers theories and principles in equilibrium pertinent to medicinal and pharmaceutical applications.
Summarizes the physical and Chemical properties of each element and group in the periodic table.
Provides the chemistry and pharmacy of inorganic medicinal official in the USP and NF with special
attention on their common names, properties, preparation, and the rationale of their therapeutic uses.

Approved by:

Assoc. Prof. Ma. Elena J. Manansala

Dean
Jan. 5, 2015

Date of Approval:

Intended Learning
Outcomes
Establish the relationship
between the principles of
chemical kinetics and
chemical equilibrium
(CILO1.1)

Formulate equilibrium
expressions as applied to
homogenous and
heterogenous systems.
(CILO 3)

Content
Unit I: Chemical Principles
Applicable
to
Pharmaceutical and
Medicinal Chemistry
1. Chemical Kinetics
Reaction rates and rate law
Collision Theory of reaction
rate
Le Chateliers Principle
Factors affecting reaction
rates

2. Chemical Equilibrium
2.2 Homogenous Equilibrium
Equlibrium Constant - Ke
Equilibrium Constant for
weak acids (Ka)
Equlbrium Constant for
weak base (Kb)
Equilbrium Constant for
Water (Kw)
pH and buffers
2.3 Heterogenous Equilbrium
Equlibrium constant for
Slightly soluble compounds
(Ksp)

Teaching-Learning
Activities

Assessment
Tasks

Lecture Demonstration
Tutorial

Objective test

Scientific Laboratory
Session (no.1)

Problem sets

Problem Solving Learning

Cooperative Group
Assignment

Lecture Demonstration
Tutorial

Objective test

Laboratory experiment
(no.2)

Problem sets

Problem Solving Learning

Cooperative Group
Assignment

Laboratory
reports

Compare and
Contrast chart
Laboratory
report

Distinguish and classify

elements on the basis of
atomic structure and come
up with their chemical
properties (CILO 1.2)
Using multimedia facilities,
search the economic and
medicinal uses of
elements(CILO 4)

Unit II: Chemistry of Elements in

the Periodic Table
1. Group Properties of Elements

Group I-A Alkali Metals

Group I-B Coinage

Metals

Group II-A Alkaline

Earth Metals

Group II-B Zn, Cd, Hg

Group III-A Boron Family

Group III-B Scandium

Family

Group IV-A Carbon

Family

Group IV-B Titanium

Family

Group V-A Nitrogen

Family

Group V-B Vanadium

Family

Group VI-A Oxygen

Family

Group VI-B Chromium

Family

Group VII-A Halogens

Group VII-B Manganese

Family

Group VIII Iron Triad

Platinum
Subgroup
Group VIII-A Inert Gases

Lecturedemonstration

Objective
test

Tutorial

Memory
matrix

Compare
and Contrast
Chart

Practical
exam

Laboratory
reports

Small Group Projects

utilizing on-line sources
of updated phar. and
medicinal uses of
elements/alloys
Scientific Laboratory
Session (nos. 3-10)

Discuss the importance

pharmaceutical aids and
necessities in the
preparation of
pharmaceutical products.
( CILO 1.3)

Relate the electrolytes to

metabolic functions and
human well being and their
interventions (CILO 5)

Discuss different official

inorganic compounds on the
basis of their therapeutic
uses and mechanisms of
action (CILO 1.3)
Recognize the different
preparations available in
the drugstore containing
inorganic compounds. (CILO
2)

Unit III: Classification of

Inorganic Compounds
According to their Uses
1. Pharmaceutical Aids and
Necessities
Acids and Bases
Buffers
Antioxidants
Waters
Pharmaceutically Acceptable
Glass
2. Major Intra- and Extra-cellular
Electrolytes
Major Physiological Ions
Electrolytes used in Acidbase Therapy
Physiological Acid-Base
Balance
Electrolytes used in AcidBase Therapy
Electrolytes Combination
therapy
3. Essential, Non-Essential and
Trace Ions
Essential Ions
Non-Essential ions
Trace Ions
4. Gastrointestinal Agents
Acidifying
Antacids
Protectives and Adsorbents
Saline Cathartics
5. Topical Agents

Lecture

Objective test

Course Preparation
Assignment

Memory matrix

Note taking
Small group project and
assignment
Audio-visual presentations
of currents medicinal uses of
inorganic preparations and
their mechanism of actions.
Scientific Laboratory
session(nos. 11-17)

Compare and
contrast chart
Laboratory reports
and
pharmaceutical
preparation

 Protective Agents
Antibacterials and
Astringents
6. Dental Products
Anticaries Agents
Dentrifices
7. Miscellaneous Pharmaceutical
Agents
Inhalants
Respiratory Stimulus
Expectorants and Emetics
Antidotes
Tableting Aids
Suspending Agents
8. Radiopharmaceuticals and
Contrast Media
Radiopharmaceuticals
Radiopaque and Contrast
Media

Course Textbook:
Zumdahl, S.S and Zumdahl S.A, Chemistry: An Atomic First Approach. Australia:
Thomson Brooks/Cole, 2012.
Manansala, M.E., Lecture Notes in Phar. Chem 1.
Manansala,M.E., Doria, M.C., Laboratory Manual in Phar. Chem 1
Course References:
and Pharmaceutical

Block, John H.; Roche, Edward; Soine, Taito; Wilson, Charles, Inorganic Medicinal

Chemistry. Philadelphia: Lea and Febiger, 1974

Chang, Raymond. General Chemistry The Essential Concepts, 5th edition. McGraw
Hill 2008.
Remingtons Pharmaceutical Sciences
USP 36, NF 31

Grading System:
Lecture
Quizzes
Assignments/Proje
cts
Long Exams
Total
Ratio
Laboratory
Quizzes
Long Exams
Reports/Performan
ce
Practical/Preparati
ons

Monthly

Prelims

Finals

40%

40%

40%

10%

10%

10%

50%
100%
30%

50%
100%
30%

50%
100%
30%

Monthly
40%
40%

Prelims
40%
40%

Finals
40%
40%

10%

10%

10%

10%

10%

10%

100%

100%

100%

Comprehensive
Exam
Monthly Scope
20%
Prelim Scope
40%
Final Scope 40%
100%
10%