1)

Cardiac
enzymes are

PGI pattern Test & Discussion

a) CK-MB
b) LDH
c) SGOT
d) SGPT
e) Troponin
2) TRUE about follicular dendritic
cells
a) Mesenchymal in origin
b) found in germinal centres of
lymphoid organs
c) present antigen to T cells
d) bind to icosomes
e) important for B-cell
maturation
3) Stop codon(s) are
a) UAA
b) UAG
c) UGA
d) UAU
e) UGG
4) Trinucleotide repeat disorders
are

a) Used in cDNA synthesis

b) RNA dependent DNA
polymerase
c) DNA dependent DNA
polymerase
d) Telomere is an example
e) Useful in HIV infection
6) What are all the features of
polymerase used in PCR
a) Thermostable
b) 53 polymerase activity
c) Requires primer
d) 53 exonuclease activity
7) B12 dependent enzymes are
a) Methionine synthase
b) Methyl malonyl coA mutase
c) Lysine amino mutase
d) Leucine aminomutase
e) Cystathionine synthase
8) B1 dependent enzymes are

a) Alzheimers disease

a) PDH

b) Amyotrophic lateral sclerosis

b) keto glutarate
dehydrogenase

c) Ataxia telangiectasia
d) Huntingtons chorea

c) Branched chain keto acid

dehydrogenase

e) Kennedys disease

d) Transketolase

5) True statement(s) about reverse

transcriptase

e) Transaldolase
9) Biotin dependent enzymes are

Dr. Karthikeyan Pethusamy

PGI pattern Test & Discussion

a)

Acetyl coA carboxylase

b) Pyruvate carboxylase
c) Propionyl coA carboxylase
d) Vitamin K dependent
carboxylation
e) Methylcrotonyl-CoA
carboxylase
10)

Raised anion gap is seen in

13)

BMR is increased in

a) Addisons disease
b) Hypothyroidism
c) Fever (pyrexia)
d) Hyperthyroidism
e) Cold environment
14)
Markers of plasma
membrane are
a) Na+K+ATPase
b) Adenylate kinase

a) Multiple myeloma

c) 5 Nucleotidase

b) Lithium poisoning

d) Adenylyl cyclase

c) Uremia

e) 5 deiodinase

d) Aspirin poisoning
e) Lactic acidosis type I
11)

FAD acts as a coenzyme for

15)

Selenoproteins are

a) 5 deiodinase
b) Glutathione reductase

a) Succinate dehydrogenase

c) 5 Nucleotidase

b) AcylcoA dehydrogenase

d) Glutathione peroxidase

c) Malate dehydrogenase

e) Thioredoxin reductase

d) Glutathione reductase

16)

Coenzyme A is made up of

e) Glutathione peroxidase

a) Pantothenate

12)
Which of the following first
messengers use cGMP as 2nd
messenger?

b) Beta alanine
c) adenosine 3' phosphate

a) Glucagon

d) Thio ethanolamine

b) Adrenaline

e) Biotin

c) NO

17)

Oncogenes are

d) ANF

a) RAS

e) Gastrin

b) MYC

Dr. Karthikeyan Pethusamy

c)
HER2

PGI pattern Test & Discussion

d) BCL2
e) BID
18)
TRUE about mitochondrial
DNA
a) Contains 37 genes
b) Maternally inherited
c) Genetic code of mitochondira
is different
d) Mitochondrial genome is
polyploid
e) Circular & double stranded
19)
Select the TRUE statement(s)
regarding ADP-ribosylation
a) ADP-ribosylation of alpha
subunit of Gi2 type of Gprotein is done by pertussis
toxin
b) ATP is the source of ADPribose
c) ADP-ribosylation of alpha
subunit of Gs type of Gprotein is done by cholera
toxin
d) ADP-ribosylation of EF-2 is
done by diphtheria toxin
e) cAMP levels are decreased
20)

NADP act as a coenzyme for

a) Glucose 6 Phosphate
dehydrogenase
b) Malic enzyme
c) Cytoplasmic isocitrate
dehydrogenase
d) Acyl coA dehydrogenase
e) Malate dehydrogenase
21)
TRUE about micro RNA
a) transcribed by RNA
polymerase II
b) 200 nucleotides in length

c) Primary miRNA contains 5

cap and a 3 polyadenylated
tail
d) translocated to cytoplasm by
exportin-5
e) miRNA base pair with 5
untranslated region
22)
TRUE amount complement
system
a) C3b & C4b are opsonins
b) C3a ,C4a, C5a are
anaphylatoxins
c) C5b678(9)n forms membrane
attack complex
d) Early complement
component deficiency leads
to autoimmune diseases
e) Late complement component
deficiency leads to pyogenic
infections
23)
TRUE about dendritic cells
a) Dendritic cells are the most
efficient professional antigen
presenting cells
b) constitutively express MHC II
and co-stimulatory signal
molecule B7
c) can activate nave T-cell.
d) produce cytokines
e) present in skin
24)
ABC transporters are NOT
involved in
a) Intestinal absorption of copper
b) Biliary excretion of copper
c) Methotrexate resistance
d) Reverse cholesterol transport
e) Chloride transport
25)
Select the wrong statement(s)
a) DNA is more stable
b) DNAse is more stable
c) RNA is more stable
d) RNAse is more stable
e) Both DNAse & RNAse are
equally stable
26)
Which of the following is NOT a
disorder of ubiquitin proteasomal
system?
a) Angelman syndrome
b) Autosomal recessive juvenile
Parkinsons disease
c) Von Hippel-Lindau syndrome

Dr. Karthikeyan Pethusamy

PGI pattern Test & Discussion

d)

Congenital polycythemia
e) All of the above
27)
3 fatty acids are
a) Linoleic acid
b) Alpha Linolenic acid
c) Gamma linolenic acid
d) Docosahexaenoic Acid (DHA)
e) Eicosapentaenoic acid (EPA)
28)
Pentoses are
a) Arabinose
b) Xylose
c) Ribose
d) Xylulose
e) Erythrose

29)

18 carbon fatty acids are

a) Arachidonic acid
b) Linoleic acid
c) Oleic acid
d) Palmitic acid
e) Stearic acid
30)

Lipotropic factors are

a) Choline
b) Methionine
c) Betaine
d) Selenium
e) Vitamin E
31)
Reactions happening inside
the Mitochondria are
a) TCA cycle
b) Omega oxidation of fatty
acids

e) Part of gluconeogenesis
32)

Select the TRUE statements

a) Liver cell lacks thiophorase

b) Humans lack L-Gulonolactone
oxidase and cellulase
c) Myocyte lacks Glucose-6phosphatase
d) Adipocyte lacks Glycerol
kinase
e) Hepatocyte lacks Glucose-6phosphatase
33)
Sulphur containing amino
acids found in proteins are
a) Methionine
b) Cysteine
c) Homocysteine
d) Taurine
e) Serine
34)

Glutathione is made up of

a) Glycine
b) Arginine
c) Methionine
d) Cysteine
e) Glutamate
35)
Irreversible steps of
glycolysis are

c) Elongation of long chain fatty

acids

a) Phosphorylation of glucose
by hexokinase

d) Ketone body production

b) Reaction by aldolase

Dr. Karthikeyan Pethusamy

c)

PGI pattern Test & Discussion

Reaction by pyruvate kinase

d) Reaction by
phosphoglyceromutase
e) Reaction by
Phosphofructokinase
36)
Enzymes catalysing substrate
level phosphorylation reactions
are
a) Pyruvate Kinase
b) Phosphofructo kinase
c) Phosphoglycerate kinase
d) Creatine phosphokinase
(Lohman reaction)
e) Succinate thio kinase
37)
Cofactors for Pyruvate
Dehydrogenase complex
a) TPP (B1)
b) Lipoamide
c) CoA (B5)
d) FAD (B2)
e) NAD (B3)
38)
Amino acids that do not
undergo transamination are
a) Leucine
b) Lysine
c) Threonine
d) Glutamate
e) Aspartate

39)
Key enzymes of
Gluconeogenesis are
a) Phosphoenol pyruvate
carboxy kinase
b) Fructose 1, 6 bisphosphatase
c) Pyruvate carboxylase
d) Glucose-6-phosphatase
e) Pyruvate kinase
40)Which is/are NOT true about
collagen?
a) Collagen helix is a right
handed alpha helix
b) Tertiary structure of collagen
is left-handed triple helix
c) Triple helix structure is
formed intracellularly
d) Self-assembly is the cardinal
principle in collagen
maturation
e) Hydroxy proline residues are
glycosylated
41)Which of the following is/are form
of non-apoptotic programed cell
death?
a)
b)
c)
d)
e)
42)

Necroptosis
Pyroptosis
Ceruloptosis
Ferroptosis
Karyoptosis
Select the true statement:

a) Zinc is involved in the

storage of insulin
b) Calcium is involved in insulin
release
c) Chromium is an insulin
sensitizer
d) Insulin inhibits Lipoprotein
lipase

Dr. Karthikeyan Pethusamy

e)

PGI pattern Test & Discussion

Insulin causes intracellular shift

of pottasium
43)
All are true regarding tRNA
EXCEPT
a) 74 to 95 nucleotides long
b) There are at least 20 species of
tRNA molecules in every cell
c) Do not undergo any processing
like mRNA
d) 5 end of tRNA contains CCA
e) Transcribed by RNA
polymerase II
44)
All are true about
microsatellite repeats EXCEPT
a) consist of 2 to 6 nucleotides
repeated up to 50 times
b) Repeats of 2 nucleotides
(dinucleotide repeats) is the
most common form of
microsatellite.
c) Highly polymorphic
d) co-dominantly inherited
e) Multi-allelic
45)
Which of the following pair of
gene and its chromosomal
location is INCORRECT?
a) RB 13
b) CFTR 7
c) MHC I 6
d) TP53 17
e) WT1 11
46)
Which is NOT a disorder with
X-linked dominant inheritance?
a) Vit D dependent rickets
b) Rett syndrome
c) Incontinentia pigmenti
d) Fragile-X-Syndrome
e) Most cases of Alport
syndrome
47)
Ribozymes are
a) Peptidyl transferase
b) Telomerase
c) Spliceosomes
d) Group I introns
e) Reverse transcriptase
48)
Prokaryotic DNA polymerase I
contain
a) 5'3' polymerase activity
b) 3'5' polymerase activity
c) 3'5' exonuclease activity

d) 5'3' exonuclease activity

e) 5'3' endonuclease activity
49)
Inhibitors of translation in
eukaryotic organisms are
a) Cycloheximide
b) Ricin
c) Diphtheria toxin
d) Puromycin
e) Linezolid

Answers
1) Cardiac enzymes are
a) CK-MB
b) LDH
c) SGOT
d) SGPT
e) Troponin
2) TRUE about follicular dendritic
cells
a) Mesenchymal in origin
b) found in germinal centres of
lymphoid organs
c) present antigen to T cells
d) bind to icosomes
e) important for B-cell
maturation
3) Stop codon(s) are
a) UAA
b) UAG
c) UGA
d) UAU

Dr. Karthikeyan Pethusamy

e)
UGG

PGI pattern Test & Discussion

4) Trinucleotide repeat disorders

are

e) Cystathionine synthase
8) B1 dependent enzymes are

a) Alzheimers disease

a) PDH

b) Amyotrophic lateral sclerosis

b) keto glutarate
dehydrogenase

c) Ataxia telangiectasia
d) Huntingtons chorea

c) Branched chain keto acid

dehydrogenase

e) Kennedys disease

d) Transketolase

5) True statement(s) about reverse

transcriptase
a) Used in cDNA synthesis
b) RNA dependent DNA
polymerase
c) DNA dependent DNA
polymerase
d) Telomere is an example
e) Useful in HIV infection
6) What are all the features of
polymerase used in PCR

e) Transaldolase
9) Biotin dependent enzymes are
a) Acetyl coA carboxylase
b) Pyruvate carboxylase
c) Propionyl coA carboxylase
d) Vitamin K dependent
carboxylation
e) Methylcrotonyl-CoA
carboxylase
10)

Raised anion gap is seen in

a) Thermostable

a) Multiple myeloma

b) 53 polymerase activity

b) Lithium poisoning

c) Requires primer

c) Uremia

d) 53 exonuclease activity

d) Aspirin poisoning

7) B12 dependent enzymes are

a) Methionine synthase

e) Lactic acidosis type I

11)

FAD acts as a coenzyme for

b) Methyl malonyl coA mutase

a) Succinate dehydrogenase

c) Lysine amino mutase

b) AcylcoA dehydrogenase

d) Leucine aminomutase

c) Malate dehydrogenase

Dr. Karthikeyan Pethusamy

PGI pattern Test & Discussion

d)

Glutathione reductase

16)

Coenzyme A is made up of

e) Glutathione peroxidase

a) Pantothenate

12)
Which of the following first
messengers use cGMP as 2nd
messenger?

b) Beta alanine
c) adenosine 3' phosphate

a) Glucagon

d) Thio ethanolamine

b) Adrenaline

e) Biotin

c) NO

17)

Oncogenes are

d) ANF

a) RAS

e) Gastrin

b) MYC

13)

BMR is increased in

a) Addisons disease
b) Hypothyroidism
c) Fever (pyrexia)
d) Hyperthyroidism
e) Cold environment
14)
Markers of plasma
membrane are
f) Na+K+ATPase
g) Adenylate kinase
h) 5 Nucleotidase
i) Adenylyl cyclase
j) 5 deiodinase
15)

Selenoproteins are

a) 5 deiodinase
b) Glutathione reductase
c) 5 Nucleotidase
d) Glutathione peroxidase
e) Thioredoxin reductase

c) HER2
d) BCL2
e) BID
18)
TRUE about mitochondrial
DNA
a) Contains 37 genes
b) Maternally inherited
c) Genetic code of mitochondira
is different
d) Mitochondrial genome is
polyploid
e) Circular & double stranded
19)
Select the TRUE statement(s)
regarding ADP-ribosylation
a) ADP-ribosylation of alpha
subunit of Gi2 type of Gprotein is done by pertussis
toxin
b) ATP is the source of ADPribose
c) ADP-ribosylation of alpha
subunit of Gs type of Gprotein is done by cholera
toxin
d) ADP-ribosylation of EF-2 is
done by diphtheria toxin
e) cAMP levels are decreased

Dr. Karthikeyan Pethusamy

PGI pattern Test & Discussion

20)
NADP
act as a coenzyme for

a) Glucose 6 Phosphate
dehydrogenase
b) Malic enzyme
c) Cytoplasmic isocitrate
dehydrogenase
d) Acyl coA dehydrogenase
e) Malate dehydrogenase
21)
TRUE about micro RNA
a) transcribed by RNA
polymerase II
b) 200 nucleotides in length
c) Primary miRNA contains 5
cap and a 3 polyadenylated
tail
d) translocated to cytoplasm by
exportin-5
e) miRNA base pair with 5
untranslated region
22)
TRUE amount complement
system
a) C3b & C4b are opsonins
b) C3a ,C4a, C5a are
anaphylatoxins
c) C5b678(9)n forms membrane
attack complex
d) Early complement
component deficiency leads
to autoimmune diseases
e) Late complement component
deficiency leads to pyogenic
infections
23)
TRUE about dendritic cells
a) Dendritic cells are the most
efficient professional antigen
presenting cells
b) constitutively express MHC II
and co-stimulatory signal
molecule B7
c) can activate nave T-cell.
d) produce cytokines
e) present in skin
24)
ABC transporters are NOT
involved in
a) Intestinal absorption of copper

b) Biliary excretion of copper

c) Methotrexate resistance
d) Reverse cholesterol transport
e) Chloride transport
25)
Select the wrong statement(s)
a) DNA is more stable
b) DNAse is more stable
c) RNA is more stable
d) RNAse is more stable
e) Both DNAse & RNAse are
equally stable
26)
Which of the following is NOT a
disorder of ubiquitin proteasomal
system?
a) Angelman syndrome
b) Autosomal recessive juvenile
Parkinsons disease
c) Von Hippel-Lindau syndrome
d) Congenital polycythemia
e) All of the above
27)
3 fatty acids are
a) Linoleic acid
b) Alpha Linolenic acid
c) Gamma linolenic acid
d) Docosahexaenoic Acid (DHA)
e) Eicosapentaenoic acid (EPA)
28)
Pentoses are
a) Arabinose
b) Xylose
c) Ribose
d) Xylulose
e) Erythrose

29)

18 carbon fatty acids are

a) Arachidonic acid
b) Linoleic acid
c) Oleic acid
d) Palmitic acid
e) Stearic acid
30)

Lipotropic factors are

a) Choline
b) Methionine
c) Betaine
Dr. Karthikeyan Pethusamy

PGI pattern Test & Discussion

d)
Selenium

a) Glycine

e) Vitamin E

b) Arginine

31)
Reactions happening inside
the Mitochondria are

c) Methionine
d) Cysteine

a) TCA cycle
e) Glutamate
b) Omega oxidation of fatty
acids
c) Elongation of long chain fatty
acids

35)
Irreversible steps of
glycolysis are
a) Phosphorylation of glucose
by hexokinase

d) Ketone body production

b) Reaction by aldolase
e) Part of gluconeogenesis
c) Reaction by pyruvate kinase
32)

Select the TRUE statements

a) Liver cell lacks thiophorase

d) Reaction by
phosphoglyceromutase

b) Humans lack L-Gulonolactone

oxidase and cellulase

e) Reaction by
Phosphofructokinase

c) Myocyte lacks Glucose-6phosphatase

d) Adipocyte lacks Glycerol
kinase
e) Hepatocyte lacks Glucose-6phosphatase

36)
Enzymes catalysing substrate
level phosphorylation reactions
are
a) Pyruvate Kinase
b) Phosphofructo kinase
c) Phosphoglycerate kinase

33)
Sulphur containing amino
acids found in proteins are

d) Creatine phosphokinase
(Lohman reaction)

a) Methionine
e) Succinate thio kinase
b) Cysteine
c) Homocysteine

37)
Cofactors for Pyruvate
Dehydrogenase complex

d) Taurine

a) TPP (B1)

e) Serine

b) Lipoamide

34)

Glutathione is made up of

c) CoA (B5)

Dr. Karthikeyan Pethusamy

d)
FAD
(B2)

PGI pattern Test & Discussion

e) NAD (B3)
38)
Amino acids that do not
undergo transamination are
a) Leucine
b) Lysine
c) Threonine
d) Glutamate
e) Aspartate
39)
Key enzymes of
Gluconeogenesis are
a) Phosphoenol pyruvate
carboxy kinase
b) Fructose 1, 6 bisphosphatase
c) Pyruvate carboxylase
d) Glucose-6-phosphatase
e) Pyruvate kinase
40)Which is/are NOT true about
collagen?
a) Collagen helix is a right
handed alpha helix
b) Tertiary structure of collagen
is left-handed triple helix
c) Triple helix structure is
formed intracellularly
d) Self-assembly is the cardinal
principle in collagen
maturation
e) Hydroxy proline residues are
glycosylated
41)Which of the following is/are form
of non-apoptotic programed cell
death?
a) Necroptosis
b) Pyroptosis

c)
d)
e)
42)

Ceruloptosis
Ferroptosis
Karyoptosis
Select the true statement:

a) Zinc is involved in the

storage of insulin
b) Calcium is involved in insulin
release
c) Chromium is an insulin
sensitizer
d) Insulin inhibits Lipoprotein
lipase
e) Insulin causes intracellular
shift of potassium
f)
43)
All are true regarding tRNA
EXCEPT
f) 74 to 95 nucleotides long
g) There are at least 20 species of
tRNA molecules in every cell
h) Do not undergo any processing
like mRNA
i) 5 end of tRNA contains CCA
j) Transcribed by RNA
polymerase II
44)
All are true about
microsatellite repeats EXCEPT
a) consist of 2 to 6 nucleotides
repeated up to 50 times
b) Repeats of 2 nucleotides
(dinucleotide repeats) is the
most common form of
microsatellite.
c) Highly polymorphic
d) co-dominantly inherited
e) Multi-allelic
45)
Which of the following pair of
gene and its chromosomal
location is INCORRECT?
a) RB 13
b) CFTR 7
c) MHC I 6
d) TP53 17

Dr. Karthikeyan Pethusamy

PGI pattern Test & Discussion

e)
WT1
11
46)
Which is NOT a disorder with
X-linked dominant inheritance?
a) Vit D dependent rickets
b) Rett syndrome
c) Incontinentia pigmenti
d) Fragile-X-Syndrome
e) Most cases of Alport
syndrome
47)
Ribozymes are
a) Peptidyl transferase
b) Telomerase
c) Spliceosomes
d) Group I introns
e) Reverse transcriptase
48)
Prokaryotic DNA polymerase I
contain
a) 5'3' polymerase activity
b) 3'5' polymerase activity
c) 3'5' exonuclease activity
d) 5'3' exonuclease activity
e) 5'3' endonuclease activity
49)
Inhibitors of translation in
eukaryotic organisms are
a) Cycloheximide
b) Ricin
c) Diphtheria toxin
d) Puromycin
e) Linezolid
50)
High energy phosphate
compounds are:

Dr. Karthikeyan Pethusamy