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Arboviruses:
A- Belong to 3 main families: Togaviruses, Buynaviruses,
and Flaviviruses.
B- Animal-Arthropod-Man:
• Reservoir is in the animal.
• Example: Japanese Encephalitis, Jungle Yellow
Fever, EEE, and WEE.
ARBOVIRUSES
Rift Valley
Dengue Fever Yellow Fever
Fever
Bunyaviridae
Virus (enveloped,
Flaviviridae (RNA viruses)
family segmented, negative
s/s RNA)
Several subtypes
Virus Four with many
including
serotypes subtypes
the Zinga virus
Monkeys (Jungle
Reservoir Humans Animals
Yellow Fever)
Man-Arthropod-Man
Transmissi Man - Arthropod - (Urban YF) and/or Animal - Arthropod -
on Cycle Man Animal-Arthropod-Man Man
(Jungle YF)
Route of Insect bite Insect bite
Transmissi (transovarial Insect bite / Direct
on transmission may also contact with the
occur) blood of an infected
animal (transovarial
transmission may also
occur)
Asymptomatic and
Asymptomatic,
mild /
Infection Atypical, or Classical
Sub-clinical in cats
with a fever
and dogs
In Humans:
Hemorrhagic fever,
Jaundice, liver or
necrotic hepatitis,
Hemorrhage (Dengue kidney failure,
kidney problems,
Hemorrhagic Fever) albuminuria,
Complicati hepato-renal failure,
and/or shock (very low leucopenia,
ons encephalitis, bilateral
BP Dengue Shock thrombocytopenia,
vision, blindness, and
Syndrome) and
even death. In
systemic bleeding
pregnant animals:
Abortion
Non-immune people in
densely populated
Susceptible
Children areas (Urban YF) /
GPs
Forest workers (Jungle
YF)
50% (without
Mortality High (esp. in newborn
treatment) / Recovery High
rate animals)
is long and difficult
In RT-PCR, the
presence of PCR-
Cross-reactive Abs inhibiting factors in
Problems formed against other the sample could give
in Flaviviruses may false (- ve) results.
Diagnosis interfere with the Qiagen viral RNA
results extraction Kit is used
to
remove such inhibitors
Symptomatic (but
No specific TTT (just
avoid Aspirin), fluid
symptomatic but
balance, and
Treatment avoiding Aspirin in the
blood/platelet
acute phase) /
transfusion
Ribavirin can be used
(if necessary)