Professional Documents
Culture Documents
COPD
Set of lung diseases that limit air flow and not fully reversible even with
medications
Usually progressive and associated with inflammation of the lungs
True
T or F: COPD is [reventable by avoiding precipitating factors
True
T or F: Symptomatic treatment for COPD is available and more common in
men than women
Emphysema
Permanent abnormal enlargement of the air sacs distal to the terminal
bronchiole with destruction of alveolar septa and attachments to the bronchial walls
Breakdown of elastin by proteases
Destruction of alveolar septa in COPD is caused by
Chronic bronchitis
Excessive tracheobronchial mucus production; Inflammation of major and
small airways
At least 3 months of the year for 2 consecutive years
In chronic bronchitis, conditions is sufficient to cause cough with
expectoration for most days of ______
Smoking
Primary risk factor for COPD
Oxidative stress
Elastin breakdown
Chemoattractant
Decrease ciliary function
Hypertrophy and hyperplasia of mucus secreting glands
DNA damage
Effects of smoking
Air pollution
A cause of COPD where pollutants promotes mucus hypersecretion, airway
inflammation, may cause infection
Occupation
A cause of COPD where exposure to organic and inorganic dust or noxious
gases caused accelerated decline in lung function
Infection
A major factor associated with etiology as well as progression of disease (eg.
Pneumonia) in COPD
a1-antitrypsin deficiency
Genetic factor that can cause COPD
Global Initiative for Chronic Obstructive Lung Disease
Meaning of GOLD
0
Stage of GOLD - AT RISK of COPD
I
Stage for mild COPD accdng to GOLD
II
Stage for moderate COPD accdng to GOLD
III
Stage for severe COPD accdng to GOLD
IV
Stage of very severe COPD accdng to GOLD
STAGE I
Characterized by mild airflow limitation
STAGE I
( FEV1> 80%, FEV1/FVC < 70%)
STAGE I
Stage where symptoms of chronic cough and sputum production may be
present, but not always
STAGE II
characterized by worsening air flow limitation
STAGE II
(50% < FEV1 < 80%; FEV1/FVC <70%)
STAGE II
With shortness of breath, typically developing on effort, cough and sputum
production are also present.
STAGE III
characterized by further worsening air flow limitation
STAGE III
(30% < FEV1 < 50%; FEV1/FVC < 70%)
STAGE III
Greater shortness of breath, reduce exercise capacity, fatigue and repeated
exacerbation that almost always have an impact on patients quality of life
STAGE IV
Characterized by sever air flow limitation
STAGE IV
(FEV1 < 30% or FEV1 < 50% plus the presence of chronic respiratory failure;
FEV1/FVC < 70%)
STAGE IV
At this stage, quality of life is very appreciably impaired and exacerbation
may be life threatening
True
T or F: Patient may have stage IV, very severe COPD even if the FEV1 > 30%,
whenever this complications are present
False
T or F: COPD can be managed and cured
True
T or F: Pharmacotherapy can prevent and control symptoms of COPD
True
T or F: Pharmacotherapy can reduce frequency and severity of exacerbations
of COPD
True
T or F: Pharmacotherapy can improve health status and quality of life of COPD
patients
Influenza vaccination
False
T or F: ICS monotherapy can also be for COPD rather than asthma only
ANTIBIOTICS
Used to treat bacterial infection as evidenced by an increase in volume or
change in color or viscosity of the sputum
Dyspnea Sputum Volume & Purulence
Antibiotics are useful to COPD pateints if there is an increase in any of these
3 symptoms
Co-Amoxiclav
Most commonly used antibiotic for COPD
Mucolytics
May improve sputum clearance and disrupt mucus plugs
Acetylcysteine
Mucolytic drug used in COPD
Expectorants
May be used, but the evidence of effectiveness is anecdotal
Guaifenesin
Glyceryl guiacolate
Terpin hydrate
Iodine products
Expectorants that may be used in COPD
Oxygen therapy
For very severe COPD; if used more than 15 hrs per day, shows increase in
survival
Oxygen therapy
Used as long term continuous therapy, during exercise or to relieve acute
dyspnea
Influenza vaccine
Given annually to patients with COPD
Pneumococcal vaccine
Given to All patients > 65 yo with COPD
False
T or F: Pneumococcal vaccine cannot be given to anyone >65 yo or if smokers