Professional Documents
Culture Documents
Function
Source
Disease
Association
G-CSF
stimulates neutrophil
development/release from BM
Macs, Fibroblasts
acute infection
TGF1
----------------
IL-1 family
Macs/mono, lymphocytes,
neutrophils
IL-2
deficient in T cell-deficient
diseases
IL-3
Increased in allergic
diseases,
lymphocytic/acute myeloid
leukemia
IL-4
Increased in
allergy/asthma,
CLL
IL-5
Increased in
asthma/allergy
Hypereosinophilic
syndrome
IL-6
Endothelial cells
monocytes, macrophages,
T cells
IL-7
DC, B cells,
monocytes/macrophages
Increased in psoriasis,
allergy
IL-8
Monocytes/macrophages,
neutrophils, lymphocytes
in inflammatory diseases
(RA, psoriasis, infections)
IL-9
Increased in helminth
infections, Hodgkins
lymphoma, allergy
IL-10
Immune suppression
Increased in some
cancers, allergy;
in autoinflammatory
disease
5/2/12
Cytokine
Function
Source
Disease
Association
IL-11
allergic inflammation
IL-12
monocytes/macs,
neutrophils/DC
IL-13
Increased in asthma,
allergic rhinitis, parasite
infections
IL-15
T Cell activation,
Monocytes/macrophages
proliferation/activation NK cells,
CD8 memory T cell homeostasis,
enhance TH2 differentiation
IL-17
TH17 cells
CD8+ T cells
NK cells
NKT cells
neutrophils
IL-18
enhance NK cytotoxicity,
inhibits T Reg development
Macrophage, DC
IL-23
Macrophages,
DC
IL-33
necrotic cells,
endothelial cells
cardiovascular disease,
asthma,
autoimmune disease
IFN-
Weak antiviral,
cytotoxic activity, TH1
differentiation,
MHC I, II; enhance microbial
killing by macrophages
antitumor, antibacterial
properties; increased in
Th1-mediated autoimmune
diseases
5/2/12
Increased in
autoimmune/inflammatory
diseases
IFN /
mono/macs; fibroblasts
LT(TNF 2)
B/T cells
TNF
Macs, NK, T
5/2/12
Anti-viral, anti-parasitic,
anti-proliferative
in some autoimmune
diseases () MS treatment
????
Granuloma control; High
levels septic shock;
Deficiency increase
tumors/leukemias;
in RA, MS