Desirable Specifications for Total Error, Imprecision, and Bias, derived from intraand inter-individual biologic variation

This most recent and extensive listing of biologic goals has been provided by Ricos C, Alvarez V, Cava F, GarciaLario JV, Hernandez A, Jimenez CV, Minchinela J, Perich C, Simon M. "Current databases on biologic variation:
pros, cons and progress." Scand J Clin Lab Invest 1999;59:491-500. This database was most recently updated in
2010: see what was updated here.
Annex I, Part I: Within-subject and between-subject CV values of analytes and Desirable Analytical Quality
Specifications for imprecision, bias and total error

Note on abbreviations:
CVw = within-subject biologic variation
CVg = between-subject biologic variation
I = desirable specification for imprecision
B = desirable specification for inaccuracy
TE = desirable specification for allowable total error
Analyte
SSUSUSSSSUPSSUSSUSSSSSSPSPSS-

11-Desoxycortisol
17-Hydroxyprogesterone
4 OH-3 methoxi-Vanil mandelic acid
(VMA)
5' Nucleotidase
5'-Hydroxyindolacetate, concentration
1-Acid Glycoprotein
1-Antichymotrypsin
1-Antitrypsin
1-Globulin
1-Microglobulin, concentration, first
morning
2-Antiplasmin
2-Globulins
2-Macroglobulin
2-Microglobulin output, first
morning
-Amylase
-Amylase (pancreatic)
-Amylase concentration, random
-Carotene
-Fetoprotein(non hepatic carcinoma)
-Tocopherol
Acid phosphatase
Acid phosphatase tartrate-resistant
(TR-ACP)
Acid phosphatase prostatic activity
(PAP)
Activated partial thromboplastine time
Acyl/free carnitine
Adiponectin
Adenosine deaminase (ADA)
Alanine aminopeptidase

Biological
Variation
CVw
CVg
21.3
31.5
19.6
52.4

Desirable
specification
I(%)
B(%)
TE(%)
10.7
9.5
27.1
9.8
14.0
30.2

22.2

47.0

11.1

13.0

31.3

11.3
20.3
11.3
13.5
5.9
11.4

12.6
33.2
24.9
18.3
16.3
22.6

5.7
10.2
5.7
6.8
3.0
5.7

4.2
9.7
6.8
5.7
4.3
6.3

13.6
26.5
16.2
16.8
9.2
15.7

33.0

58.0

16.5

16.7

43.9

6.2
10.3
3.4

--12.7
18.7

3.1
5.2
1.7

--4.1
4.8

--12.6
7.6

29.0

32.0

14.5

10.8

34.7

8.7
11.7
94.0
35.8
12.0
13.8
8.9

28.3
29.9
46.0
65.0
46.0
15.0
8.0

4.4
5.9
47.0
17.9
6.0
6.9
4.5

7.4
8.0
26.2
18.6
11.9
5.1
3.0

14.6
17.7
103.7
48.1
21.8
16.5
10.3

8.0

13.3

4.0

3.9

10.5

33.8

---

16.9

---

---

2.7
10.4
18.8
11.7
4.1

8.6
27.2
51.2
25.5
---

1.4
5.2
9.4
5.9
2.1

2.3
7.3
13.6
7.0
---

4.5
15.9
29.1
16.7
--1

SSUSUSSSSUSSSPPSSSSSSSSSSSSSSSSUUUSSBSSSSSSSSPPSSSSSUU-

Alanine aminotransferase
Albumin
Albumin, concentration, first morning
Aldosterone
Aldosterone, concentration
Alkaline phosphatase
Alkaline phosphatase, bone
Alkaline phosphatase, liver
Alkaline phosphatase, placental
Ammonia, output, 24h
Amyloid A
Androstendione
Androstenedione
Angiotensin converting enzyme
Antithrombin III
Apolipoprotein A1
Apolipoprotein B
Ascorbic Acid
Aspartate aminotransferase
2-Microglobulin
Basophile, count
-Carotene
-Cryptoxantin
-Globulins
Bilirubin total
Bilirubin conjugated
CA 125 antigen
CA 15.3 antigen
CA 19.9 antigen
CA 549 antigen
Calcium
Calcium, concentration, 24h
Calcium, ionized
Calcium, output, 24h
Carbohydrate deficient transferrin
Carcinoembryonic antigen (CEA)
CD4 lymphocyte count
Ceruloplasmin
Chloride
Cholesterol
Cholinesterase
Cholinesterase, activity
Cholinesterase, immunoreactive
C3 complement
C4 complement
Chromogranin A
Copper
Copper
Cortisol
C Peptide
C-Propeptide type I procollagen
C-Reactive protein
C-Terminal cross-linking telopeptide
type I collagen (s-CTx)
C-Telopeptide of type I
collagen/creatinine, 1st morning

24.3
3.1
36.0
29.4
32.6
6.4
6.2
10.0
19.1
24.7
25.0
11.1
11.1
0.1
5.2
6.5
6.9
26.0
11.9
5.9
28.0
36.0
36.7
10.1
23.8
36.8
24.7
6.1
16.0
9.1
1.9
27.5
1.7
26.2
7.1
12.7
25.0
5.8
1.2
5.4
7.0
5.4
6.4
5.2
8.9
12.8
8.0
4.9
20.9
16.6
8.2
42.2

41.6
4.2
55.0
40.1
39.0
24.8
35.6
27.0
--27.3
61.0
51.1
51.1
--15.3
13.4
22.8
31.0
17.9
15.5
54.8
39.7
--9.1
39.0
43.2
54.6
62.9
102.0
33.4
2.8
36.6
1.9
27.0
38.7
55.6
--11.1
1.5
15.2
10.4
10.3
--15.6
33.4
26.3
19.0
13.6
45.6
23.2
17.6
76.3

12.2
1.6
18.0
14.7
16.3
3.2
3.1
5.0
9.6
12.4
12.5
5.6
5.8
0.1
2.6
3.3
3.5
13.0
6.0
3.0
14.0
18.0
18.4
5.1
11.9
18.4
12.4
3.1
8.0
4.6
1.0
13.8
0.9
13.1
3.6
6.4
12.5
2.9
0.6
2.7
3.5
2.7
3.2
2.6
4.5
6.4
4.0
2.5
10.5
8.3
4.1
21.1

12.0
1.3
16.4
12.4
12.7
6.4
9.0
7.2
--9.2
16.5
13.1
13.1
--4.0
3.7
6.0
10.1
5.4
4.1
15.4
13.4
--3.4
11.4
14.2
15.0
15.8
25.8
8.7
0.8
11.4
0.6
9.4
9.8
14.3
--3.1
0.5
4.0
3.1
2.9
--4.1
8.6
7.3
5.2
3.6
12.5
7.1
4.9
21.8

32.1
3.9
46.1
36.7
39.6
11.7
14.1
15.4
--29.6
37.1
22.2
22.6
--8.3
9.1
11.6
31.6
15.2
9.0
38.5
43.1
--11.7
31.1
44.5
35.4
20.8
39.0
16.2
2.4
34.1
2.0
31.0
15.7
24.7
--7.9
1.5
8.5
8.9
7.4
--8.4
16.0
17.9
11.8
7.7
29.8
20.8
11.6
56.6

9.6

30.6

4.8

8.0

15.9

32.8

48.0

16.4

14.5

41.6
2

USSSSSPatientUUSSPUSUUUPSPSB(B)PlatPBBUSPPPPSP(B)Erthry
SSSSUSUSSSSSSSS(B)ErythrB - spot

C-Telopeptide type I
collagen/creatinine, 2nd morning
Creatine kinase (CK)
Creatine kinase MB, %
Creatine kinase MB, activity
Creatine kinase MB, mass
Creatinine
Creatinine clearance
Creatinine, concentration, 24h
Creatinine, output, 24h
Cyfra 21.1
Cystastin C
Cysteine
?-aminolevulinic acid
Dehydroepiandrosterone sulfate
Deoxypyridinoline/creatinine, 24h
(Delmas CC 2001)
Deoxypyridinoline/creatinine, first
morning
Deoxipyridinoline/minute
Dipeptidyl-peptidase IV (ACE)
Dipeptidyl-peptidase IV (ACE)
Elastase
Endotelial growth factor
Eosinophils, count
Epinephrine
Epinephrine
Erythrocytes, count
Erythrocyte distribution wide
Estradiol
Estradiol
Factor V coagulation
Factor VII coagulation
Factor VIII coagulation
Factor X coagulation
Ferritin
Fibrinogen

23.4

---

11.7

---

---

22.8
6.9
19.7
18.4
5.3
13.6
24.0
11.0
22.5
4.6
5.9
16.0
4.2

40.0
48.2
24.3
61.2
14.2
13.5
24.5
23.0
31.1
13.0
12.3
27.0
29.3

11.4
3.45
9.9
9.2
2.7
6.8
12.0
5.5
11.3
2.3
3.0
8.0
2.1

11.5
12.17
7.8
16.0
3.8
4.8
8.6
6.4
9.6
3.4
3.4
7.8
7.4

30.3
17.87
24.1
31.2
8.2
16.0
28.4
15.4
28.2
7.2
8.3
21.0
10.9

13.5

17.6

6.8

5.5

16.7

13.1

19.0

6.6

5.8

16.6

26.5
8.2
12.5
13.6
10.7
21.0
25.3
48.3
3.2
3.5
30.4
18.1
3.6
6.8
4.8
5.9
14.2
10.7

35.7
14.5
27.7
16.4
47.6
76.4
----6.1
5.7
--19.7
--19.4
19.1
--15.0
15.8

13.3
4.1
6.3
6.8
5.4
10.5
12.7
24.2
1.6
1.8
15.2
9.1
1.8
3.4
2.4
3.0
7.1
5.4

11.1
4.2
7.6
5.3
12.2
19.8
----1.7
1.7
--6.7
--5.1
4.9
--5.2
4.8

33.0
10.9
17.9
16.5
21.0
37.1
----4.4
4.6
--21.6
--10.7
8.9
--16.9
13.6

Folate

12.0

66.0

6.0

16.8

26.7

Folate
Follicle stimulating hormone (males)
Free carnitine
Free estradiol
Free estradiol
Free testosterone
Free testosterone
Free thyroxine (FT4)
Free Triiodothyronine (FT3)
Fructosamine
Galactosyl hydroxylisine
-Globulins
-glutamyltransferase
Globulins, total
Glucose
Glucose-6-phosphate-1-dehydrogenase
(G6PDH)
Glucose-6-phosphate-1-dehydrogenase

24.0
8.7
7.6
22.8
38.6
9.3
51.7
5.7
7.9
3.4
11.8
14.6
13.8
5.5
5.7

73.0
18.0
15.2
--------12.1
17.6
5.9
25.8
12.3
41.0
12.9
6.9

12.0
4.4
3.8
11.4
19.3
4.7
25.9
2.9
4.0
1.7
5.9
7.3
6.9
2.8
2.9

19.2
5.0
4.2
--------3.3
4.8
1.7
7.1
4.8
10.8
3.5
2.2

39.0
12.2
10.5
--------8.0
11.3
4.5
16.8
16.8
22.2
8.0
6.9

32.8

31.8

16.4

11.4

38.5

7.3

10.3

3.7

3.2

9.2
3

SSSP, SBBBSSSSPSUSSSSSSSSS(B)LeucSSSBSSSSSSPPSSPSBSSSSSBB(B)Erythr-

(G6PDH)
Glutathion peroxidase
Glycated albumin
Glycated total protein
Haptoglobin
Hematocrit
Hemoglobin
Hemoglobin A1 C
HDL cholesterol
HDL 1 cholesterol
HDL 2 cholesterol
HDL 3 cholesterol
Homocysteine
Hydroxyproline/creatinine
Hydroxyproline/minute, night urine
Hydroxybutyrate dehydrogenase
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunoglobulins chains
Immunoglobulins chains
Insulin
Insulin-like growth factor (IGF-1)
Intercellular adhesion molecule-1
Interferon receptor
Interleukin-1
Interleukin-8
Iron
Lactate
Lactate dehydrogenase (LDH)
Lactate dehydrogenase 1 isoform
(LDH1)
Lactate dehydrogenase 2 isoform
(LDH2)
Lactate dehydrogenase 3 isoform
(LDH3)
Lactate dehydrogenase 4 isoform
(LDH4)
Lactate dehydrogenase 5 isoform
(LDH5)
Lactoferrin
Leukocytes, count
LDL Cholesterol
LDL Cholesterol (direct)
LDL Cholesterol (oxidized)
LDL receptor mRNA
Leukocytes count
Lipase
Lipoprotein (a)
Lutein
Luteinizing hormone
Lycopenene
Lymphocytes, count
Lymphocytes CD4
Magnesium

7.2
5.2
0.9
20.4
2.8
2.8
3.4
7.1
5.5
15.7
7.0
9.0
25.9
36.1
8.8
5.4
4.5
5.9
4.8
4.8
21.1
9.4
1.9
14.0
30.0
24.0
26.5
27.2
8.6

21.7
10.3
11.6
36.4
6.4
6.6
5.1
19.7
27.2
40.7
14.3
40.3
38.0
38.8
--35.9
16.5
47.3
15.3
18.0
58.3
27
21.0
20.0
36.0
31.0
23.2
16.7
14.7

3.6
2.6
0.5
10.2
1.4
1.4
1.7
3.6
2.8
7.9
3.5
4.5
13.0
18.1
4.4
2.7
2.3
3.0
2.4
2.4
10.6
4.7
1.0
7.0
15.0
12.0
13.3
13.6
4.3

5.7
2.9
2.9
10.4
1.7
1.8
1.5
5.2
6.9
10.9
4.0
10.3
11.5
13.2
--9.1
4.3
11.9
4.0
4.7
15.5
7.1
5.3
6.1
11.7
9.8
8.8
8.0
4.3

11.7
7.2
3.7
27.3
4.1
4.1
4.3
11.1
11.5
23.9
9.8
17.7
32.9
43.0
--13.5
8.0
16.8
8.0
8.6
32.9
14.9
6.8
17.7
36.5
29.6
30.7
30.4
11.4

6.3

10.2

3.2

3.0

8.2

4.9

4.3

2.5

1.6

5.7

4.8

5.5

2.4

1.8

5.8

9.4

9.0

4.7

3.3

11.0

12.4

13.4

6.2

4.6

14.8

11.8
10.9
8.3
6.5
21.0
21.5
10.9
23.1
8.5
19.5
14.5
40.1
10.4
25.0

23.7
19.6
25.7
--50.0
13.6
19.6
33.1
85.8
21.0
27.8
33.0
27.8
---

5.9
5.5
4.2
3.3
10.5
10.8
5.5
11.6
4.3
9.8
7.3
20.1
5.2
12.5

6.6
5.6
6.8
--13.6
6.4
5.6
10.1
21.6
7.2
7.8
--7.4
---

16.4
14.6
13.6
--30.9
24.1
14.6
29.1
28.6
23.3
19.8
--16.0
---

5.6

11.3

2.8

3.2

7.8
4

(B)LeucSUUU(B)Erythr(B)Erythr(B)Erythr(B)PlatBSSSUBUSB(Plat)PUSSSSUUBBBSSSSSSUUPatientSPBBBUU(B)LeucSUUSSS-

Magnesium
Magnesium
Magnesium, concentration, 24h
Magnesium, ionized
Magnesium, output, 24h
Mean corpuscular hemoglobin (HCM)
Mean corpuscular hemoglobin
concentration (MCHC)
Mean corpuscular volume (MCV)
Mean platelet volume (MPV)
Monocytes, count
Mucinous carcinoma-associated
antigen (MCA)
Myeloperoxidase
Myoglobin
N-Acetyl Glucosaminidase,
concentration, overnight
Neutrophyles, count
Nitrogen, output
Non-inhibited arilestearase activity
Norepinephrine
Norepinephrine
N- Telopeptide of type I collagen
/creatinine, first urine
N-terminal (NT)-proBNP
Osmolality
Osteocalcin
Osteocalcin (+1 trab)
Oxalate, concentration, 24h
Oxalate, output, 24h
pCO2
pH [H+]
pH (pH units)
Paraoxon
Paraoxonase 1 substrate inhibition
(PON 4SI)
Paraoxonase activity (salt estimulated)
Parathyroid hormone (PTH)
Phenylacetate
Phosphate
Phosphate, concentration, 24h
Phosphate, output, 24h
Phosphate tubular reabsorption
Phospholipids
Plasminogen
Platelets, count
Platelet distribution wide
Plateletcrit
Porphobilinogen
Porphyrins
Potassium
Potassium
Potassium, concentration, 24h
Potassium, output
Prealbumin
Procollagen type 1 C-terminal
Procollagen type 1 N-terminal

18.3
3.6
45.4
1.9
38.3
1.6

16.4
6.4
37.4
5.1
37.6
5.2

9.2
1.8
22.7
1.0
19.2
0.8

6.1
1.8
14.7
1.4
13.4
1.4

21.2
4.8
52.2
2.9
45.0
2.7

1.7

2.8

0.9

0.8

2.2

1.3
4.3
17.8

4.8
8.1
49.8

0.7
2.2
8.9

1.2
2.3
13.2

2.3
5.8
27.9

10.1

39.3

5.1

10.1

18.5

36.0
13.9

30.0
29.6

18.0
7.0

11.7
8.2

41.4
19.6

48.6

18.4

24.3

13.0

53.1

16.1
13.9
3.8
9.5
19.5

32.8
24.2
37.2
-----

8.1
7.0
1.9
4.8
9.8

9.1
7.0
9.3
-----

22.4
18.4
12.5
-----

17.2

44.8

8.6

12.0

26.2

20.8
1.3
6.3
7.2
44.0
42.5
4.8
3.5
0.2
13.4

36.2
1.2
23.1
27.0
18.0
19.9
5.3
2.0
--84.0

10.4
0.7
3.2
3.6
22.0
21.3
2.4
1.8
0.1
6.7

10.4
0.4
6.0
7.0
11.9
11.7
1.8
1.0
--21.3

27.6
1.5
11.2
12.9
48.2
46.8
5.7
3.9
--32.3

3.9

80.1

1.9

20.0

23.2

8.0
25.9
6.6
8.5
26.4
18.0
2.7
6.5
7.7
9.1
2.8
11.9
17.0
40.0
13.6
4.8
27.1
24.4
10.9
7.8
6.8

86.4
23.8
25.2
9.4
26.5
22.6
3.3
11.1
--21.9
----31.0
--13.4
5.6
23.2
22.2
19.1
--18.4

4.0
13.0
3.3
4.3
13.2
9.0
1.4
3.3
3.9
4.6
1.4
6.0
8.5
20.0
6.8
2.4
13.6
12.2
5.5
3.9
3.4

21.7
8.8
6.5
3.2
9.4
7.2
1.1
3.2
--5.9
----8.8
--4.8
1.8
8.9
8.2
5.5
--4.9

28.3
30.2
12.0
10.2
31.1
22.1
3.3
8.6
--13.4
----22.9
--16.0
5.8
31.3
28.4
14.5
--10.5
5

SPSSSPUUSPUBBSSSSPSSSPBSemenSemenSemenSemenSemenSemenS(B)Erythr(B)LeucSSSweatUUPSS(B)ErythrSSalivaUSSSSSSSSSS-

Prolactin (men)
Prolyl endopeptidase
Properdin factor B
Prostatic specific antigen (PSA)
Protein C
Protein S
Protein, concentration, 24h
Protein, output, 24h
Protein, total
Prothrombin time
Pyridinoline/creatinine, morning spot
Pyruvate
Red cell distribution wide (RDW)
Reticulocyte highly fluorescent, count
Reticulocyte low fluorescent, count
Reticulocyte medium fluorescent,
count
Reticulocyte, count
Retinol
Retinol
Rheumatoid factor
SCC antigen
Selenium
Selenium
Semen, concentration
Semen, morphology
Semen, progressive motility
Semen, progressive rapid motility
Semen, total motility
Semen, vitality
Sex hormone binding globulin
(SHBG)
Sodium
Sodium
Sodium
Sodium Bicarbonate
Sodium Chloride
Sodium, concentration, 24 h.
Sodium output, 24 h.
Soluble CD163
Soluble CD163
Superoxide dismutase
Superoxide dismutase
Testosterone
Testosterone
Testosterone
Thyroglobulin
Thyroglobulin antibody
Thyroid peroxidase antibody
Thyroid stimulating hormone (TSH)
Thyrotropin receptor antibody
Thyroxine binding globulin (TBG)
Thyroxine (T4)
Tissue polypeptide antigen (TPA)
Tissue polypeptide specific antigen
(TPS)
Total carnitine

6.9
16.8
9.5
18.1
5.8
5.8
39.6
35.5
2.7
4.0
8.7
15.2
3.5
10.0
1.6

61.2
13.9
11.2
72.4
55.2
63.4
17.8
23.7
4.0
6.8
17.6
13.0
5.7
62.0
4.9

3.5
8.4
4.7
9.1
2.9
2.9
19.8
17.8
1.4
2.0
4.4
7.6
1.8
5.0
0.8

15.4
5.5
3.7
18.7
13.9
15.9
10.9
10.7
1.2
2.0
4.9
5.0
1.7
15.7
1.3

21.1
19.3
11.5
33.6
18.7
20.7
43.5
40.0
3.4
5.3
12.1
17.5
4.6
24.0
2.6

13.0

33.0

6.5

8.9

19.6

11.0
6.2
13.6
8.5
39.4
12.0
12.0
26.8
19.6
15.2
18.8
18.4
10.3

29.0
21.0
19.0
24.5
35.7
14.0
12.0
56.4
44.0
32.8
51.8
29.8
25.8

5.5
3.1
6.8
4.3
19.7
6.0
6.0
13.4
9.8
7.6
9.4
9.2
5.2

7.8
5.5
5.8
6.5
13.3
4.6
4.2
15.6
12.0
9.0
13.8
8.8
6.9

16.8
10.6
17.1
13.5
45.8
14.5
14.1
37.7
28.2
21.6
29.3
23.9
15.4

12.1

42.7

6.1

11.1

21.1

1.8
51.0
0.7
4.8
15.0
24.0
28.7
9.0
4.5
17.1
12.3
9.3
17.3
25.0
14
8.5
11.3
19.3
4.8
4.4
4.9
28.7

12.4
36.4
1.0
4.7
25.0
26.8
16.7
35.9
4.5
10.5
4.9
23.7
28.8
--39
82.0
147.0
24.6
--12.6
10.9
40.4

0.9
25.5
0.4
2.4
7.5
12.0
14.4
4.5
2.3
8.6
6.2
4.7
8.7
12.5
7.0
4.3
5.7
9.7
2.4
2.2
2.5
14.4

3.1
15.7
0.3
1.7
7.3
9.0
8.3
9.3
1.6
5.0
3.3
6.4
8.4
--10.4
20.6
36.9
7.8
--3.3
3.0
12.4

4.6
57.7
0.9
5.6
19.7
28.8
32.0
16.7
5.3
19.1
13.5
14.0
22.7
--21.9
27.6
46.2
23.7
--7.0
7.0
36.1

36.1

108.0

18.1

28.5

58.3

7.7

13.8

3.9

4.0

10.3
6

UUSSSSSSUUSUUUSSPB(B)Eryth(B)Eryth(B)Eryth(B)ErythB(B)Eryth(B)Eryth(B)ErythSPPSSSP-

Total catecolamines, concentration,

24h
Total porphyrins
Transferrin
Triglyceride
Triiodothyronine (T3)
Troponin I
Tumor Necrosis Factor-
Urate
Urate, concentration, 24h
Urate, output, 24h
Urea
Urea, concentration, 24h
Urea, output, 24h
Vanilmandelic Acid concentration, 24h
Vascular cell adhesion molecule-1
Vascular endotelial growth factor
Vitamin B1
Vitamin B2 (Riboflavin)
Vitamin B2 (Riboflavin)
Vitamin B2 status (gluthation
reductase activation)
Vitamin B12
Vitamin B6
Vitamin B6
Vitamin B6 status (AST activation)
Vitamin E (-Tocopherol)
Vitamin K (Phylloquinone)
VLDL Cholesterol
Von Willebrand factor
Von Willebrand factor antigen
Water
Zeaxanthine
Zinc
Zinc

24.0

32.0

12.0

10.0

29.8

40.0
3.0
20.9
8.7
14.0
43.0
9.0
24.7
18.5
12.3
22.7
17.4
22.2
5.2
14.1
4.8
5.8
6.4

--4.3
37.2
17.2
63.0
29.0
17.6
22.1
14.4
18.3
25.9
25.4
47.0
16.0
28.8
12.0
10.0
11.0

20.0
1.5
10.5
4.4
7.0
21.5
4.5
12.4
9.3
6.2
11.4
8.7
11.1
2.6
7.1
2.4
2.9
3.2

--1.3
10.7
4.8
16.1
13.0
4.9
8.3
5.9
5.5
8.6
7.7
13.0
4.2
8.0
3.2
2.9
3.2

--3.8
27.9
12.0
27.7
48.4
12.4
28.7
21.1
15.7
27.3
22.1
31.3
8.5
19.6
7.2
7.7
8.5

5.2

40.0

2.6

10.1

14.4

15.0
14.0
20.0
1.4
7.6
38.0
27.6
0.001
5.0
3.1
34.7
9.3
11.0

69.0
24.0
34.0
44.0
21.0
44.0
--28.3
18.0
0.1
--9.4
14.0

7.5
7.0
10.0
0.7
3.8
19.0
13.8
0.0005
2.5
1.6
17.4
4.7
5.5

17.7
6.9
9.9
11.0
5.6
14.5
--7.1
4.7
0.8
--3.3
4.5

30.0
18.5
26.4
12.2
11.9
45.9
--7.1
8.8
3.3
--11.0
13.5