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Complement Pathways
- Classical pathway initiated by Ag-Ab complexes or binding
of antibody to antigen on target cell ( specific to nonspecific)
- Lectin pathway plasma lectin binds to microbial
carbohydrates(mannose)
- Alternative pathway caused by various cell surface
constituents that are foreign to host
C1 activates C4
C1b associated with complex , C1a is floats away
C1
C1q needs to bind to 2 Fc sites for activated (IgM is
involved) IgM in circulation will be in planar form , when
bound to antigen it will have a spider/staple form.
C1r is activated by C1q configurational change
MBL
Binds to mannose residues and MASP-2 and 3 are exposed
, same activation events take place with MBL like C1q
Activation of classical pathway
Needs Ig to start
Starts on cell bound to Ab
Larger fragments are the ones that associate